ENSG00000144589

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000413891 ENSG00000144589 HEK293_OSMI2_2hA HEK293_TMG_2hB STK11IP protein_coding nonsense_mediated_decay 15.65261 18.9762 10.36952 1.166567 0.829296 -0.8712115 0.8173939 0.5696478 0.3856852 0.12234149 0.14113923 -0.55082350 0.05284583 0.02953333 0.03576667 0.006233333 9.240771e-01 7.102082e-12 TRUE TRUE
ENST00000456909 ENSG00000144589 HEK293_OSMI2_2hA HEK293_TMG_2hB STK11IP protein_coding protein_coding 15.65261 18.9762 10.36952 1.166567 0.829296 -0.8712115 8.4904727 13.5595008 5.0143826 1.05103091 0.17078742 -1.43334942 0.52806250 0.71356667 0.48836667 -0.225200000 3.351812e-04 7.102082e-12 FALSE TRUE
ENST00000465230 ENSG00000144589 HEK293_OSMI2_2hA HEK293_TMG_2hB STK11IP protein_coding retained_intron 15.65261 18.9762 10.36952 1.166567 0.829296 -0.8712115 0.7120875 0.2358867 0.7986070 0.06422546 0.37153794 1.71744519 0.04908333 0.01220000 0.07280000 0.060600000 1.468882e-02 7.102082e-12 FALSE TRUE
ENST00000473899 ENSG00000144589 HEK293_OSMI2_2hA HEK293_TMG_2hB STK11IP protein_coding retained_intron 15.65261 18.9762 10.36952 1.166567 0.829296 -0.8712115 0.6600245 0.2639250 0.9962765 0.04597045 0.08955311 1.87717400 0.04729167 0.01376667 0.09623333 0.082466667 7.102082e-12 7.102082e-12 FALSE FALSE
ENST00000475843 ENSG00000144589 HEK293_OSMI2_2hA HEK293_TMG_2hB STK11IP protein_coding retained_intron 15.65261 18.9762 10.36952 1.166567 0.829296 -0.8712115 1.0372105 0.5152936 0.8867235 0.18201044 0.19790258 0.77153916 0.06924167 0.02720000 0.08616667 0.058966667 9.049558e-02 7.102082e-12 FALSE TRUE
ENST00000494777 ENSG00000144589 HEK293_OSMI2_2hA HEK293_TMG_2hB STK11IP protein_coding retained_intron 15.65261 18.9762 10.36952 1.166567 0.829296 -0.8712115 1.0411724 0.6699168 0.6835450 0.22805163 0.06832966 0.02863127 0.06822500 0.03643333 0.06746667 0.031033333 3.672603e-01 7.102082e-12   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000144589 E001 1.361909 0.0099669644 9.554133e-01 9.760211e-01 2 219597851 219597856 6 + 0.324 0.332 0.047
ENSG00000144589 E002 1.842378 0.0209417611 4.576971e-01 5.980119e-01 2 219597857 219597858 2 + 0.508 0.369 -0.729
ENSG00000144589 E003 4.446104 0.0127135466 3.456271e-01 4.897457e-01 2 219597859 219597870 12 + 0.777 0.629 -0.616
ENSG00000144589 E004 30.106375 0.0168626036 2.440555e-03 8.583286e-03 2 219597871 219597923 53 + 1.611 1.332 -0.961
ENSG00000144589 E005 36.636261 0.0050309604 3.012280e-04 1.384732e-03 2 219598094 219598138 45 + 1.677 1.423 -0.868
ENSG00000144589 E006 39.292752 0.0215692064 3.653746e-02 8.460085e-02 2 219598139 219598180 42 + 1.677 1.473 -0.697
ENSG00000144589 E007 1.366176 0.0230052907 9.583585e-01 9.779171e-01 2 219598194 219598277 84 + 0.324 0.332 0.048
ENSG00000144589 E008 0.000000       2 219598443 219598509 67 +      
ENSG00000144589 E009 87.546185 0.0010530178 1.875627e-03 6.840409e-03 2 219601235 219601440 206 + 1.968 1.829 -0.470
ENSG00000144589 E010 4.787605 0.0034436390 7.335347e-02 1.488878e-01 2 219601441 219601554 114 + 0.884 0.628 -1.034
ENSG00000144589 E011 54.904703 0.0004268403 1.193728e-01 2.190496e-01 2 219601641 219601715 75 + 1.730 1.642 -0.298
ENSG00000144589 E012 4.647948 0.0152218345 1.624061e-03 6.037979e-03 2 219601716 219601840 125 + 0.994 0.542 -1.838
ENSG00000144589 E013 67.980813 0.0014613048 2.968341e-01 4.381020e-01 2 219601988 219602083 96 + 1.796 1.738 -0.196
ENSG00000144589 E014 73.382359 0.0019749737 2.814290e-01 4.213329e-01 2 219602468 219602575 108 + 1.833 1.774 -0.198
ENSG00000144589 E015 72.203972 0.0014745682 4.773935e-01 6.159431e-01 2 219602705 219602776 72 + 1.807 1.768 -0.135
ENSG00000144589 E016 0.000000       2 219605507 219605528 22 +      
ENSG00000144589 E017 0.000000       2 219605529 219605607 79 +      
ENSG00000144589 E018 83.194162 0.0044354327 6.078993e-02 1.279594e-01 2 219605608 219605734 127 + 1.756 1.860 0.352
ENSG00000144589 E019 81.500104 0.0004702329 4.637387e-03 1.492413e-02 2 219605956 219606059 104 + 1.725 1.857 0.446
ENSG00000144589 E020 68.299885 0.0039789032 3.748820e-01 5.193249e-01 2 219606195 219606290 96 + 1.721 1.769 0.163
ENSG00000144589 E021 5.844854 0.0693919803 3.424472e-04 1.550083e-03 2 219606291 219606475 185 + 1.156 0.541 -2.429
ENSG00000144589 E022 55.102409 0.0006299420 6.115640e-01 7.306579e-01 2 219606476 219606517 42 + 1.646 1.669 0.080
ENSG00000144589 E023 7.202779 0.0157300706 2.218344e-11 4.369046e-10 2 219606518 219606711 194 + 1.321 0.465 -3.381
ENSG00000144589 E024 90.248640 0.0004809574 8.076783e-01 8.778016e-01 2 219606712 219606858 147 + 1.886 1.871 -0.051
ENSG00000144589 E025 57.815580 0.0004903113 8.344331e-01 8.963583e-01 2 219607053 219607137 85 + 1.682 1.688 0.021
ENSG00000144589 E026 111.691452 0.0019082723 6.820833e-01 7.856084e-01 2 219608047 219608294 248 + 1.955 1.969 0.046
ENSG00000144589 E027 88.049139 0.0003181678 3.381870e-01 4.820661e-01 2 219608295 219608396 102 + 1.836 1.874 0.126
ENSG00000144589 E028 44.072718 0.0004995452 1.029748e-01 1.950047e-01 2 219608397 219608397 1 + 1.490 1.589 0.339
ENSG00000144589 E029 60.703800 0.0017594493 3.690774e-03 1.226957e-02 2 219608398 219608430 33 + 1.575 1.742 0.569
ENSG00000144589 E030 118.324815 0.0002807339 4.721907e-02 1.042212e-01 2 219608583 219608788 206 + 1.936 2.008 0.242
ENSG00000144589 E031 59.222932 0.0004467050 7.152401e-01 8.112017e-01 2 219609097 219609145 49 + 1.687 1.702 0.049
ENSG00000144589 E032 74.207643 0.0003671547 7.015997e-01 8.006978e-01 2 219609146 219609213 68 + 1.811 1.788 -0.077
ENSG00000144589 E033 6.156141 0.0026465789 3.510164e-09 4.702900e-08 2 219609214 219609362 149 + 1.218 0.492 -2.884
ENSG00000144589 E034 130.319367 0.0025040202 9.035723e-01 9.426471e-01 2 219609363 219609540 178 + 2.038 2.039 0.006
ENSG00000144589 E035 2.018862 0.0085376618 1.307938e-03 5.003432e-03 2 219609541 219609706 166 + 0.777 0.247 -2.706
ENSG00000144589 E036 1.319123 0.1918389933 9.378272e-02 1.810358e-01 2 219610068 219610126 59 + 0.575 0.199 -2.247
ENSG00000144589 E037 169.378228 0.0002713254 9.029591e-02 1.755860e-01 2 219611604 219611834 231 + 2.109 2.158 0.166
ENSG00000144589 E038 111.000728 0.0002698774 7.090394e-01 8.065314e-01 2 219611955 219612042 88 + 1.981 1.962 -0.065
ENSG00000144589 E039 64.141249 0.0003780506 5.980884e-01 7.197509e-01 2 219612043 219612058 16 + 1.756 1.724 -0.106
ENSG00000144589 E040 2.253003 0.0069590553 3.261298e-01 4.695784e-01 2 219613051 219613127 77 + 0.576 0.403 -0.857
ENSG00000144589 E041 114.858861 0.0004970965 6.503152e-01 7.613664e-01 2 219613128 219613225 98 + 1.971 1.984 0.044
ENSG00000144589 E042 128.435434 0.0006105005 1.939940e-01 3.188111e-01 2 219613752 219613915 164 + 1.994 2.038 0.150
ENSG00000144589 E043 51.947878 0.0006868102 4.656723e-01 6.053344e-01 2 219613916 219613930 15 + 1.612 1.649 0.127
ENSG00000144589 E044 88.384683 0.0028464761 1.262286e-02 3.502068e-02 2 219614161 219614242 82 + 1.764 1.892 0.432
ENSG00000144589 E045 96.543132 0.0011622668 1.145353e-01 2.121675e-01 2 219614476 219614546 71 + 1.854 1.920 0.225
ENSG00000144589 E046 12.771907 0.0336589363 1.482297e-02 4.009377e-02 2 219614547 219614805 259 + 1.273 0.963 -1.115
ENSG00000144589 E047 3.196976 0.0049184448 4.759406e-02 1.048995e-01 2 219614806 219614871 66 + 0.777 0.464 -1.383
ENSG00000144589 E048 5.380894 0.0204769795 1.443868e-02 3.922006e-02 2 219614872 219615093 222 + 0.994 0.645 -1.376
ENSG00000144589 E049 173.680644 0.0004677329 1.114405e-01 2.076604e-01 2 219615094 219615341 248 + 2.122 2.169 0.158
ENSG00000144589 E050 5.787262 0.0028309826 4.046310e-01 5.483366e-01 2 219615707 219616043 337 + 0.851 0.732 -0.472
ENSG00000144589 E051 144.472736 0.0012353654 1.844125e-01 3.067639e-01 2 219616044 219616451 408 + 2.044 2.090 0.154