ENSG00000144580

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000273064 ENSG00000144580 HEK293_OSMI2_2hA HEK293_TMG_2hB CNOT9 protein_coding protein_coding 49.78259 59.91387 47.80511 5.691494 0.2368504 -0.3256642 10.745821 16.229382 8.117062 1.9457920 0.2319520 -0.9986910 0.21100417 0.27003333 0.16976667 -0.10026667 1.872810e-06 9.941745e-47 FALSE TRUE
ENST00000295701 ENSG00000144580 HEK293_OSMI2_2hA HEK293_TMG_2hB CNOT9 protein_coding protein_coding 49.78259 59.91387 47.80511 5.691494 0.2368504 -0.3256642 2.922711 2.495404 5.093603 0.5797614 0.1925430 1.0264729 0.06016667 0.04113333 0.10656667 0.06543333 7.905521e-05 9.941745e-47 FALSE TRUE
ENST00000418808 ENSG00000144580 HEK293_OSMI2_2hA HEK293_TMG_2hB CNOT9 protein_coding protein_coding 49.78259 59.91387 47.80511 5.691494 0.2368504 -0.3256642 4.910490 16.488052 0.000000 1.5766271 0.0000000 -10.6880800 0.08554167 0.27846667 0.00000000 -0.27846667 9.941745e-47 9.941745e-47 FALSE FALSE
ENST00000473626 ENSG00000144580 HEK293_OSMI2_2hA HEK293_TMG_2hB CNOT9 protein_coding retained_intron 49.78259 59.91387 47.80511 5.691494 0.2368504 -0.3256642 2.704247 1.072214 4.534275 0.2191878 0.4126049 2.0700638 0.05733750 0.01750000 0.09483333 0.07733333 1.629202e-14 9.941745e-47   FALSE
MSTRG.19962.2 ENSG00000144580 HEK293_OSMI2_2hA HEK293_TMG_2hB CNOT9 protein_coding   49.78259 59.91387 47.80511 5.691494 0.2368504 -0.3256642 4.404730 3.010042 4.571719 1.1568159 0.4038570 0.6013206 0.09148333 0.04933333 0.09556667 0.04623333 1.859052e-01 9.941745e-47 FALSE TRUE
MSTRG.19962.8 ENSG00000144580 HEK293_OSMI2_2hA HEK293_TMG_2hB CNOT9 protein_coding   49.78259 59.91387 47.80511 5.691494 0.2368504 -0.3256642 7.353544 5.561236 8.594229 1.3508959 1.2734042 0.6270483 0.15135417 0.09406667 0.18006667 0.08600000 1.513735e-01 9.941745e-47 FALSE FALSE
MSTRG.19962.9 ENSG00000144580 HEK293_OSMI2_2hA HEK293_TMG_2hB CNOT9 protein_coding   49.78259 59.91387 47.80511 5.691494 0.2368504 -0.3256642 13.904429 12.972212 13.927233 2.0198936 1.0191012 0.1024080 0.28450833 0.21453333 0.29130000 0.07676667 1.722708e-01 9.941745e-47 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000144580 E001 0.3686942 0.0343230330 8.158362e-01 8.834343e-01 2 218568473 218568537 65 + 0.131 0.114 -0.229
ENSG00000144580 E002 2.0511508 0.0128767466 5.539203e-01 6.829833e-01 2 218568538 218568579 42 + 0.382 0.532 0.769
ENSG00000144580 E003 36.7652018 0.0069541950 1.833831e-03 6.707606e-03 2 218568580 218568707 128 + 1.654 1.507 -0.501
ENSG00000144580 E004 36.5092867 0.0075294187 2.236675e-03 7.956499e-03 2 218568708 218568755 48 + 1.650 1.503 -0.502
ENSG00000144580 E005 32.8545449 0.0147450325 4.464331e-03 1.444104e-02 2 218568756 218568813 58 + 1.618 1.449 -0.578
ENSG00000144580 E006 10.8428815 0.0529338064 2.261224e-01 3.577572e-01 2 218568814 218568814 1 + 1.136 1.022 -0.415
ENSG00000144580 E007 13.0790596 0.0357619778 2.590505e-01 3.964164e-01 2 218568815 218568819 5 + 1.189 1.113 -0.272
ENSG00000144580 E008 25.7620620 0.0018383142 2.014968e-01 3.280394e-01 2 218568820 218568838 19 + 1.433 1.414 -0.067
ENSG00000144580 E009 39.3813348 0.0022976913 2.385415e-03 8.415139e-03 2 218568839 218568858 20 + 1.661 1.551 -0.375
ENSG00000144580 E010 44.0107610 0.0024357738 5.136227e-04 2.210406e-03 2 218568859 218568874 16 + 1.717 1.589 -0.435
ENSG00000144580 E011 103.4364650 0.0005777452 1.091348e-07 1.100919e-06 2 218568875 218568930 56 + 2.079 1.961 -0.396
ENSG00000144580 E012 123.6327889 0.0020736729 1.176902e-06 9.630292e-06 2 218568931 218568978 48 + 2.155 2.038 -0.390
ENSG00000144580 E013 0.4375944 0.0264076541 4.629905e-02 1.025753e-01 2 218573721 218573791 71 + 0.313 0.000 -11.565
ENSG00000144580 E014 0.1472490 0.0436501194 3.649827e-01   2 218573991 218573994 4 + 0.131 0.000 -9.737
ENSG00000144580 E015 4.6124441 0.0204558049 8.309846e-01 8.940428e-01 2 218573995 218574233 239 + 0.719 0.742 0.096
ENSG00000144580 E016 258.3750056 0.0029069734 1.869076e-05 1.167422e-04 2 218580561 218580740 180 + 2.452 2.376 -0.253
ENSG00000144580 E017 8.4121878 0.0019878827 8.488824e-02 1.672281e-01 2 218580995 218581114 120 + 1.037 0.914 -0.455
ENSG00000144580 E018 163.6733665 0.0005424749 7.816718e-05 4.193034e-04 2 218582971 218583016 46 + 2.240 2.199 -0.139
ENSG00000144580 E019 213.7894110 0.0050942492 2.801453e-04 1.299042e-03 2 218583017 218583086 70 + 2.375 2.293 -0.271
ENSG00000144580 E020 134.1046242 0.0008323282 1.559221e-07 1.526089e-06 2 218584612 218584616 5 + 2.185 2.085 -0.333
ENSG00000144580 E021 209.1151251 0.0034391939 2.024999e-06 1.573608e-05 2 218584617 218584671 55 + 2.378 2.270 -0.363
ENSG00000144580 E022 226.5931774 0.0034957468 7.610763e-05 4.095660e-04 2 218584672 218584721 50 + 2.397 2.320 -0.257
ENSG00000144580 E023 2.4431175 0.0064071083 3.164222e-02 7.515514e-02 2 218587305 218587400 96 + 0.688 0.398 -1.372
ENSG00000144580 E024 347.9179402 0.0002064946 1.902726e-13 5.203778e-12 2 218587586 218587695 110 + 2.581 2.511 -0.231
ENSG00000144580 E025 205.0794836 0.0002345283 6.708810e-06 4.639740e-05 2 218592304 218592315 12 + 2.336 2.297 -0.130
ENSG00000144580 E026 326.9304253 0.0016175300 3.648961e-05 2.123306e-04 2 218592316 218592402 87 + 2.536 2.496 -0.132
ENSG00000144580 E027 334.9191462 0.0007185037 3.147545e-06 2.343643e-05 2 218592616 218592707 92 + 2.544 2.512 -0.106
ENSG00000144580 E028 29.3015118 0.0006649046 4.317266e-26 5.189676e-24 2 218592708 218593072 365 + 1.740 1.104 -2.205
ENSG00000144580 E029 59.8337200 0.0305026706 2.682077e-02 6.562033e-02 2 218593528 218594107 580 + 1.851 1.725 -0.426
ENSG00000144580 E030 258.2089698 0.0002022699 1.068694e-03 4.196514e-03 2 218594108 218594168 61 + 2.414 2.414 0.002
ENSG00000144580 E031 3151.1967610 0.0011705612 3.532711e-32 6.892497e-30 2 218594169 218596298 2130 + 3.371 3.563 0.638
ENSG00000144580 E032 218.6063448 0.0093702785 9.933131e-09 1.225770e-07 2 218596299 218596334 36 + 2.075 2.458 1.280
ENSG00000144580 E033 145.2347172 0.0098473941 1.057090e-09 1.560164e-08 2 218596335 218597080 746 + 1.861 2.292 1.445