ENSG00000144559

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000455809 ENSG00000144559 HEK293_OSMI2_2hA HEK293_TMG_2hB TAMM41 protein_coding protein_coding 29.02224 37.29093 21.25334 0.6096455 0.7050236 -0.8108432 23.75084 32.97619 15.84821 0.9392066 1.041035 -1.056632 0.8077042 0.8839667 0.7441333 -0.1398333 0.0001189149 0.0001189149 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000144559 E001 1.7756548 0.0084938490 4.252390e-01 5.681857e-01 3 11790442 11790445 4 - 0.294 0.439 0.850
ENSG00000144559 E002 2.0722411 0.0076436298 2.522608e-01 3.885859e-01 3 11790446 11790447 2 - 0.294 0.503 1.171
ENSG00000144559 E003 69.1528031 0.0004043864 6.949971e-04 2.880823e-03 3 11790448 11790542 95 - 1.677 1.837 0.541
ENSG00000144559 E004 95.4620122 0.0003117476 3.655190e-07 3.322927e-06 3 11790543 11790581 39 - 1.772 1.982 0.708
ENSG00000144559 E005 1.4790553 0.1419645787 7.447368e-01 8.329614e-01 3 11807294 11807832 539 - 0.294 0.369 0.463
ENSG00000144559 E006 136.0757212 0.0002565028 1.197578e-05 7.814471e-05 3 11807833 11807895 63 - 1.978 2.124 0.488
ENSG00000144559 E007 9.5629260 0.0429139606 1.890290e-01 3.125195e-01 3 11807896 11808334 439 - 1.101 0.909 -0.709
ENSG00000144559 E008 10.6387496 0.0120059731 1.715753e-03 6.331579e-03 3 11808335 11808583 249 - 1.242 0.891 -1.281
ENSG00000144559 E009 3.3056325 0.0147270113 3.243073e-04 1.478073e-03 3 11808584 11808674 91 - 0.917 0.364 -2.470
ENSG00000144559 E010 19.1122590 0.0073997537 2.033358e-11 4.023958e-10 3 11808675 11809516 842 - 1.589 1.008 -2.043
ENSG00000144559 E011 281.0525944 0.0007685176 4.224958e-04 1.860409e-03 3 11809517 11809682 166 - 2.338 2.422 0.282
ENSG00000144559 E012 4.7284731 0.0080238420 1.905400e-02 4.945301e-02 3 11809683 11810059 377 - 0.918 0.585 -1.353
ENSG00000144559 E013 5.5229471 0.0031385181 1.912404e-03 6.954321e-03 3 11810776 11810897 122 - 1.029 0.631 -1.566
ENSG00000144559 E014 6.8997096 0.0360724156 3.930160e-04 1.747992e-03 3 11810898 11811559 662 - 1.163 0.668 -1.892
ENSG00000144559 E015 6.5484487 0.0313436077 8.977788e-01 9.387536e-01 3 11817080 11817087 8 - 0.833 0.849 0.058
ENSG00000144559 E016 17.2898303 0.0031763565 9.587954e-01 9.781733e-01 3 11817088 11817191 104 - 1.218 1.217 -0.002
ENSG00000144559 E017 304.2303113 0.0002168192 2.233530e-02 5.637373e-02 3 11817192 11817337 146 - 2.401 2.445 0.149
ENSG00000144559 E018 4.4466896 0.0327564063 5.520138e-03 1.733997e-02 3 11826718 11826805 88 - 0.966 0.531 -1.784
ENSG00000144559 E019 177.5071439 0.0016313425 7.682556e-01 8.502776e-01 3 11829714 11829755 42 - 2.199 2.203 0.012
ENSG00000144559 E020 242.9512295 0.0001791913 6.735663e-01 7.792155e-01 3 11829756 11829864 109 - 2.334 2.339 0.017
ENSG00000144559 E021 0.3268771 0.0297826729 5.680463e-01   3 11829865 11829910 46 - 0.172 0.086 -1.149
ENSG00000144559 E022 1.5135158 0.0088138491 1.226413e-04 6.259337e-04 3 11830722 11830874 153 - 0.729 0.086 -4.320
ENSG00000144559 E023 4.8704235 0.0035596347 2.510902e-02 6.209958e-02 3 11833003 11833025 23 - 0.918 0.609 -1.248
ENSG00000144559 E024 7.5159566 0.0060724293 3.434989e-03 1.153850e-02 3 11833026 11833151 126 - 1.102 0.748 -1.339
ENSG00000144559 E025 190.5347696 0.0002010445 9.692785e-01 9.847900e-01 3 11839222 11839314 93 - 2.235 2.231 -0.013
ENSG00000144559 E026 0.4762024 0.2907204964 2.927222e-01 4.337124e-01 3 11843539 11844028 490 - 0.294 0.086 -2.144
ENSG00000144559 E027 225.4948900 0.0026163713 1.337644e-01 2.393869e-01 3 11844029 11844211 183 - 2.344 2.288 -0.187
ENSG00000144559 E028 7.8397397 0.0030061109 1.368534e-03 5.204235e-03 3 11844891 11844907 17 - 1.134 0.764 -1.390
ENSG00000144559 E029 16.8135624 0.0230495176 3.526336e-04 1.590642e-03 3 11844908 11845096 189 - 1.449 1.054 -1.394
ENSG00000144559 E030 288.9630790 0.0002989719 1.711630e-04 8.400599e-04 3 11846502 11846919 418 - 2.473 2.386 -0.289