ENSG00000144524

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000350033 ENSG00000144524 HEK293_OSMI2_2hA HEK293_TMG_2hB COPS7B protein_coding protein_coding 58.29288 78.37965 49.03056 2.213682 1.178096 -0.6766878 23.387333 36.2531979 18.268512 1.1035731 0.8569560 -0.9883575 0.39222083 0.46266667 0.37296667 -0.08970000 0.03399831 5.929638e-13 FALSE  
ENST00000410024 ENSG00000144524 HEK293_OSMI2_2hA HEK293_TMG_2hB COPS7B protein_coding protein_coding 58.29288 78.37965 49.03056 2.213682 1.178096 -0.6766878 7.725252 9.1890423 7.202023 1.5234344 0.3515615 -0.3510797 0.13625833 0.11770000 0.14690000 0.02920000 0.59596583 5.929638e-13 FALSE  
ENST00000412591 ENSG00000144524 HEK293_OSMI2_2hA HEK293_TMG_2hB COPS7B protein_coding protein_coding 58.29288 78.37965 49.03056 2.213682 1.178096 -0.6766878 1.380636 0.8887201 4.525033 0.8887201 0.7617522 2.3351693 0.02642083 0.01086667 0.09170000 0.08083333 0.05664568 5.929638e-13 FALSE  
ENST00000413197 ENSG00000144524 HEK293_OSMI2_2hA HEK293_TMG_2hB COPS7B protein_coding nonsense_mediated_decay 58.29288 78.37965 49.03056 2.213682 1.178096 -0.6766878 6.271894 11.0392198 1.684514 0.9447236 0.9696306 -2.7050006 0.10390833 0.14140000 0.03526667 -0.10613333 0.37344445 5.929638e-13 FALSE  
ENST00000474042 ENSG00000144524 HEK293_OSMI2_2hA HEK293_TMG_2hB COPS7B protein_coding retained_intron 58.29288 78.37965 49.03056 2.213682 1.178096 -0.6766878 9.856893 11.3361885 7.131761 0.4700987 0.6579829 -0.6678560 0.16782917 0.14470000 0.14530000 0.00060000 1.00000000 5.929638e-13 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000144524 E001 1.144730 0.1711229850 8.701632e-01 9.204815e-01 2 231781671 231781677 7 + 0.284 0.330 0.300
ENSG00000144524 E002 1.359833 0.0099162633 6.553245e-01 7.652398e-01 2 231781678 231781684 7 + 0.284 0.376 0.583
ENSG00000144524 E003 2.432529 0.0060829648 3.724754e-01 5.169360e-01 2 231781685 231781706 22 + 0.377 0.548 0.872
ENSG00000144524 E004 2.102532 0.0070196936 5.839331e-01 7.079461e-01 2 231781707 231781707 1 + 0.377 0.487 0.583
ENSG00000144524 E005 31.440117 0.0068987897 6.281917e-04 2.636443e-03 2 231781708 231781883 176 + 1.618 1.383 -0.809
ENSG00000144524 E006 1.027748 0.0339731947 4.720740e-03 1.515274e-02 2 231786319 231786382 64 + 0.575 0.090 -3.589
ENSG00000144524 E007 4.739561 0.0105304852 2.345764e-02 5.869740e-02 2 231786383 231786433 51 + 0.923 0.625 -1.197
ENSG00000144524 E008 4.812611 0.0065100961 1.117720e-01 2.081600e-01 2 231786434 231786434 1 + 0.872 0.670 -0.811
ENSG00000144524 E009 5.145831 0.0035902011 9.192490e-02 1.781100e-01 2 231786435 231786435 1 + 0.898 0.691 -0.822
ENSG00000144524 E010 7.021594 0.0028455429 1.102177e-01 2.058667e-01 2 231786436 231786444 9 + 0.989 0.814 -0.666
ENSG00000144524 E011 8.445105 0.0340597193 4.343425e-02 9.735436e-02 2 231786445 231786447 3 + 1.112 0.843 -1.001
ENSG00000144524 E012 262.484928 0.0037223841 3.636652e-02 8.427969e-02 2 231786448 231786538 91 + 2.421 2.360 -0.202
ENSG00000144524 E013 207.365734 0.0023839063 2.539757e-03 8.882540e-03 2 231788555 231788570 16 + 2.335 2.249 -0.289
ENSG00000144524 E014 414.826265 0.0022185153 1.413904e-01 2.499477e-01 2 231788571 231788688 118 + 2.595 2.570 -0.082
ENSG00000144524 E015 246.478787 0.0010925409 2.969403e-01 4.382298e-01 2 231788689 231788732 44 + 2.319 2.367 0.163
ENSG00000144524 E016 17.821193 0.0217537930 3.240780e-11 6.205965e-10 2 231788733 231789149 417 + 1.594 0.899 -2.468
ENSG00000144524 E017 36.789956 0.0109906830 8.512634e-15 2.831260e-13 2 231789654 231790921 1268 + 1.854 1.282 -1.957
ENSG00000144524 E018 3.251416 0.0057189597 7.947023e-01 8.688578e-01 2 231790922 231790924 3 + 0.626 0.600 -0.111
ENSG00000144524 E019 5.689350 0.0216444650 2.177691e-02 5.521208e-02 2 231790925 231790946 22 + 0.989 0.689 -1.172
ENSG00000144524 E020 4.660559 0.0743529695 6.019772e-02 1.269427e-01 2 231790947 231790950 4 + 0.923 0.618 -1.229
ENSG00000144524 E021 19.598317 0.0009735115 1.059430e-04 5.493222e-04 2 231790951 231791173 223 + 1.457 1.177 -0.979
ENSG00000144524 E022 11.609230 0.0015896166 2.559500e-07 2.402108e-06 2 231791604 231791732 129 + 1.337 0.858 -1.739
ENSG00000144524 E023 301.836936 0.0010693941 3.236269e-01 4.669328e-01 2 231791733 231791808 76 + 2.446 2.438 -0.026
ENSG00000144524 E024 4.088099 0.0239719463 5.491002e-03 1.726339e-02 2 231791809 231791976 168 + 0.923 0.518 -1.683
ENSG00000144524 E025 3.530096 0.0046103325 3.454414e-02 8.079463e-02 2 231792054 231792278 225 + 0.815 0.518 -1.265
ENSG00000144524 E026 30.619365 0.0018855637 2.505874e-02 6.199547e-02 2 231793516 231794262 747 + 1.545 1.413 -0.455
ENSG00000144524 E027 427.619610 0.0008982920 9.663033e-02 1.853073e-01 2 231794263 231794351 89 + 2.604 2.585 -0.063
ENSG00000144524 E028 441.964795 0.0009992016 1.957514e-03 7.093579e-03 2 231796106 231796186 81 + 2.641 2.590 -0.171
ENSG00000144524 E029 499.861930 0.0004455338 2.043251e-02 5.240051e-02 2 231796187 231796308 122 + 2.676 2.651 -0.083
ENSG00000144524 E030 2.239172 0.0066045485 9.050215e-01 9.435406e-01 2 231796309 231796311 3 + 0.454 0.487 0.169
ENSG00000144524 E031 502.780511 0.0001172971 5.202566e-01 6.542387e-01 2 231798859 231798964 106 + 2.641 2.672 0.103
ENSG00000144524 E032 7.693215 0.0023403545 7.227838e-01 8.168247e-01 2 231801140 231801154 15 + 0.923 0.897 -0.096
ENSG00000144524 E033 15.931567 0.0011629136 6.058054e-01 7.261136e-01 2 231801155 231801207 53 + 1.143 1.209 0.235
ENSG00000144524 E034 568.296986 0.0004012813 1.066423e-01 2.005944e-01 2 231807487 231807622 136 + 2.682 2.731 0.163
ENSG00000144524 E035 1879.017235 0.0013899941 3.496865e-06 2.580116e-05 2 231807623 231808420 798 + 3.166 3.258 0.306
ENSG00000144524 E036 717.314957 0.0028375717 7.194947e-04 2.968729e-03 2 231808421 231809254 834 + 2.732 2.847 0.383