ENSG00000144504

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361678 ENSG00000144504 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKMY1 protein_coding protein_coding 5.936129 6.466067 5.435771 0.4279822 0.03202063 -0.2499815 0.1723873 0.6960741 0.00000000 0.09853628 0.00000000 -6.141747747 0.02788750 0.10673333 0.00000000 -0.106733333 6.787363e-12 6.787363e-12 FALSE TRUE
ENST00000480230 ENSG00000144504 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKMY1 protein_coding retained_intron 5.936129 6.466067 5.435771 0.4279822 0.03202063 -0.2499815 1.3048505 1.8714980 1.06018311 0.11892285 0.06399492 -0.814024080 0.21682500 0.29350000 0.19513333 -0.098366667 1.500135e-01 6.787363e-12 FALSE TRUE
ENST00000489677 ENSG00000144504 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKMY1 protein_coding retained_intron 5.936129 6.466067 5.435771 0.4279822 0.03202063 -0.2499815 0.3667864 0.1378177 0.07859081 0.07285526 0.07859081 -0.738590518 0.05710000 0.02070000 0.01456667 -0.006133333 7.473764e-01 6.787363e-12   FALSE
MSTRG.20166.10 ENSG00000144504 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKMY1 protein_coding   5.936129 6.466067 5.435771 0.4279822 0.03202063 -0.2499815 0.1482352 0.3146914 0.00000000 0.31469138 0.00000000 -5.020997177 0.02261667 0.05353333 0.00000000 -0.053533333 8.033606e-01 6.787363e-12 TRUE TRUE
MSTRG.20166.17 ENSG00000144504 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKMY1 protein_coding   5.936129 6.466067 5.435771 0.4279822 0.03202063 -0.2499815 0.7478819 1.1646575 1.16919176 0.46276187 0.04921925 0.005558159 0.13470833 0.17370000 0.21520000 0.041500000 7.646926e-01 6.787363e-12 TRUE TRUE
MSTRG.20166.19 ENSG00000144504 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKMY1 protein_coding   5.936129 6.466067 5.435771 0.4279822 0.03202063 -0.2499815 0.7091492 0.6805013 0.79155952 0.11117869 0.08975414 0.215165601 0.11998750 0.10486667 0.14543333 0.040566667 4.805542e-01 6.787363e-12 FALSE TRUE
MSTRG.20166.22 ENSG00000144504 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKMY1 protein_coding   5.936129 6.466067 5.435771 0.4279822 0.03202063 -0.2499815 0.3831456 0.1848714 0.88037188 0.14595006 0.22747176 2.191885846 0.07042500 0.02906667 0.16240000 0.133333333 1.022753e-01 6.787363e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000144504 E001 1.8497387 0.0366682216 3.601687e-01 0.5044837027 2 240479422 240479425 4 - 0.331 0.507 0.953
ENSG00000144504 E002 2.7741421 0.0111119630 1.749416e-01 0.2945970369 2 240479426 240479426 1 - 0.402 0.637 1.126
ENSG00000144504 E003 2.7741421 0.0111119630 1.749416e-01 0.2945970369 2 240479427 240479428 2 - 0.402 0.637 1.126
ENSG00000144504 E004 2.9558465 0.0054926410 1.205924e-01 0.2208114731 2 240479429 240479454 26 - 0.402 0.664 1.242
ENSG00000144504 E005 2.6581287 0.0059133872 3.965153e-01 0.5402674682 2 240479455 240479459 5 - 0.464 0.608 0.678
ENSG00000144504 E006 4.2812239 0.0039065354 1.606177e-01 0.2759433394 2 240479460 240479491 32 - 0.565 0.778 0.904
ENSG00000144504 E007 4.9036286 0.0034012902 6.767323e-02 0.1394881000 2 240479492 240479493 2 - 0.565 0.835 1.127
ENSG00000144504 E008 5.5699534 0.0033384788 1.954285e-02 0.0505052070 2 240479494 240479494 1 - 0.565 0.900 1.378
ENSG00000144504 E009 19.1880479 0.0010263332 4.531288e-05 0.0002580151 2 240479495 240479596 102 - 1.038 1.396 1.267
ENSG00000144504 E010 21.6778413 0.0028568000 5.965271e-03 0.0185156507 2 240479597 240479655 59 - 1.190 1.419 0.800
ENSG00000144504 E011 18.9870436 0.0010285276 2.188393e-01 0.3490187348 2 240480754 240480936 183 - 1.342 1.254 -0.310
ENSG00000144504 E012 20.5923230 0.0019446876 4.199440e-01 0.5632026009 2 240480937 240480992 56 - 1.268 1.339 0.248
ENSG00000144504 E013 23.4325494 0.0010430006 3.972633e-01 0.5410247929 2 240480993 240481097 105 - 1.327 1.396 0.240
ENSG00000144504 E014 11.3293022 0.0057123934 1.306930e-02 0.0360719052 2 240482183 240482261 79 - 0.874 1.157 1.041
ENSG00000144504 E015 2.5789392 0.0262729162 4.186255e-02 0.0944700654 2 240497105 240497309 205 - 0.716 0.379 -1.592
ENSG00000144504 E016 3.5406899 0.0044628498 7.401916e-01 0.8296734774 2 240497699 240497892 194 - 0.608 0.664 0.242
ENSG00000144504 E017 35.7645445 0.0007723040 1.982774e-01 0.3240652873 2 240499958 240500123 166 - 1.488 1.573 0.291
ENSG00000144504 E018 26.6370512 0.0008755839 4.871950e-01 0.6248739467 2 240500452 240500523 72 - 1.392 1.446 0.187
ENSG00000144504 E019 20.5034940 0.0009985842 9.266231e-01 0.9577863948 2 240500524 240500543 20 - 1.311 1.311 -0.001
ENSG00000144504 E020 18.7680595 0.0010533919 6.086352e-01 0.7283024505 2 240500544 240500565 22 - 1.294 1.261 -0.118
ENSG00000144504 E021 15.2720943 0.0054208566 4.276745e-01 0.5705219198 2 240507560 240507691 132 - 1.231 1.165 -0.233
ENSG00000144504 E022 2.1066991 0.0081700745 8.159468e-01 0.8835035531 2 240507692 240507864 173 - 0.464 0.508 0.218
ENSG00000144504 E023 1.7757591 0.0095653124 4.058280e-02 0.0920918708 2 240509348 240509455 108 - 0.608 0.263 -1.873
ENSG00000144504 E024 3.1773814 0.0418856513 8.339773e-01 0.8960363437 2 240511861 240512001 141 - 0.608 0.581 -0.119
ENSG00000144504 E025 31.0966719 0.0070227716 9.777338e-01 0.9901728282 2 240512802 240512942 141 - 1.483 1.489 0.023
ENSG00000144504 E026 0.3289534 0.0295431075 8.091516e-01   2 240519755 240520109 355 - 0.140 0.106 -0.458
ENSG00000144504 E027 18.1892561 0.0010211255 6.919027e-01 0.7932636625 2 240520362 240520454 93 - 1.241 1.280 0.138
ENSG00000144504 E028 16.9675238 0.0011679237 7.966328e-01 0.8702200081 2 240520455 240520533 79 - 1.241 1.226 -0.051
ENSG00000144504 E029 0.1451727 0.0429727337 3.571405e-01   2 240521938 240521938 1 - 0.140 0.000 -12.071
ENSG00000144504 E030 135.2073888 0.0052417930 7.732668e-05 0.0004153829 2 240521939 240523257 1319 - 1.999 2.180 0.605
ENSG00000144504 E031 47.6847642 0.0233070125 2.091818e-01 0.3375379320 2 240523258 240523822 565 - 1.597 1.717 0.407
ENSG00000144504 E032 16.0162287 0.0549502475 5.558788e-01 0.6846641624 2 240523823 240523884 62 - 1.157 1.256 0.348
ENSG00000144504 E033 43.5973962 0.0005245208 7.342085e-01 0.8252217624 2 240523885 240524009 125 - 1.641 1.630 -0.037
ENSG00000144504 E034 76.8733659 0.0003719996 3.400469e-02 0.0797692658 2 240524010 240524303 294 - 1.919 1.843 -0.258
ENSG00000144504 E035 46.8605310 0.0005115278 1.237893e-01 0.2253588713 2 240524304 240524381 78 - 1.704 1.633 -0.242
ENSG00000144504 E036 51.4742977 0.0004350220 1.617499e-01 0.2773979295 2 240525685 240525803 119 - 1.739 1.678 -0.205
ENSG00000144504 E037 34.2404536 0.0005945434 4.689850e-02 0.1036461308 2 240525804 240525849 46 - 1.597 1.487 -0.375
ENSG00000144504 E038 6.3201593 0.0051354945 7.136728e-01 0.8100946221 2 240525850 240526228 379 - 0.874 0.834 -0.154
ENSG00000144504 E039 3.1050726 0.0965468392 7.328809e-01 0.8242570459 2 240526229 240526236 8 - 0.565 0.633 0.301
ENSG00000144504 E040 7.8459299 0.1285022231 7.464548e-01 0.8342114840 2 240526237 240526445 209 - 0.974 0.918 -0.210
ENSG00000144504 E041 9.7543136 0.0064219803 6.174168e-01 0.7352301596 2 240526446 240527881 1436 - 1.053 1.006 -0.172
ENSG00000144504 E042 8.7305890 0.0108322924 6.586535e-01 0.7676922534 2 240529037 240529040 4 - 0.990 0.945 -0.167
ENSG00000144504 E043 35.9742908 0.0125122118 3.801755e-02 0.0873854743 2 240529041 240529509 469 - 1.637 1.484 -0.521
ENSG00000144504 E044 0.3030308 0.3622500541 1.956002e-01   2 240532076 240532135 60 - 0.247 0.000 -12.128
ENSG00000144504 E045 0.2965864 0.2432701102 3.749084e-01   2 240552742 240552913 172 - 0.000 0.188 11.069
ENSG00000144504 E046 35.4877359 0.0008682055 4.323490e-02 0.0969832656 2 240552914 240553033 120 - 1.613 1.503 -0.378
ENSG00000144504 E047 18.7792479 0.0010322163 5.360475e-01 0.6678133030 2 240553034 240553057 24 - 1.303 1.261 -0.148
ENSG00000144504 E048 4.5781922 0.0486461055 6.057087e-02 0.1275889651 2 240553058 240554865 1808 - 0.874 0.584 -1.195
ENSG00000144504 E049 28.3016682 0.0064639835 7.167937e-03 0.0216598744 2 240554866 240554978 113 - 1.558 1.367 -0.656
ENSG00000144504 E050 18.6338449 0.0046595388 2.357837e-02 0.0589442237 2 240554979 240555055 77 - 1.378 1.197 -0.635
ENSG00000144504 E051 2.6677678 0.1258023154 9.860926e-01 0.9953076561 2 240555056 240555560 505 - 0.518 0.552 0.160
ENSG00000144504 E052 3.1332870 0.0051320442 9.720311e-01 0.9865183778 2 240557190 240557352 163 - 0.608 0.608 0.000
ENSG00000144504 E053 1.1791606 0.0113939294 9.528388e-01 0.9744630040 2 240557353 240557406 54 - 0.331 0.324 -0.043
ENSG00000144504 E054 0.1472490 0.0428959396 3.570848e-01   2 240557881 240558021 141 - 0.140 0.000 -12.072
ENSG00000144504 E055 2.7218306 0.0055044599 7.332314e-01 0.8244757056 2 240558304 240558619 316 - 0.517 0.577 0.279
ENSG00000144504 E056 13.2607559 0.0077034306 2.022069e-04 0.0009733829 2 240560731 240560927 197 - 1.319 0.959 -1.293
ENSG00000144504 E057 7.3540763 0.0880692357 3.756125e-02 0.0865146889 2 240560928 240561035 108 - 1.081 0.745 -1.278
ENSG00000144504 E058 13.3574532 0.0041649146 7.290618e-01 0.8213529775 2 240561036 240564814 3779 - 1.108 1.149 0.146
ENSG00000144504 E059 1.1081710 0.0404333412 2.046306e-01 0.3319460904 2 240569036 240569209 174 - 0.140 0.379 1.869