ENSG00000144455

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000272902 ENSG00000144455 HEK293_OSMI2_2hA HEK293_TMG_2hB SUMF1 protein_coding protein_coding 10.94873 9.926767 11.22136 1.347329 0.2219636 0.176684 9.6114610 8.98084585 8.7010588 1.14885178 0.2466870 -0.04560877 0.8795958 0.9064333 0.77676667 -0.12966667 0.01073003 0.01073003 FALSE TRUE
MSTRG.22396.7 ENSG00000144455 HEK293_OSMI2_2hA HEK293_TMG_2hB SUMF1 protein_coding   10.94873 9.926767 11.22136 1.347329 0.2219636 0.176684 0.2384082 0.09654169 0.7532662 0.05373806 0.3520741 2.84076827 0.0221375 0.0086000 0.06603333 0.05743333 0.14852399 0.01073003 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000144455 E001 0.4502799 0.0352859369 7.876216e-02 0.1575284700 3 3700814 3702461 1648 - 0.301 0.000 -13.410
ENSG00000144455 E002 0.3332198 0.0303610612 9.814589e-01   3 3777725 3777803 79 - 0.125 0.120 -0.073
ENSG00000144455 E003 0.1515154 0.0445282856 4.728095e-01   3 3779241 3779322 82 - 0.125 0.000 -11.826
ENSG00000144455 E004 0.0000000       3 3781352 3782502 1151 -      
ENSG00000144455 E005 0.1515154 0.0445282856 4.728095e-01   3 3782503 3782637 135 - 0.125 0.000 -11.826
ENSG00000144455 E006 0.0000000       3 3782638 3782701 64 -      
ENSG00000144455 E007 0.2944980 0.3626087219 2.813796e-01   3 3788914 3789074 161 - 0.222 0.000 -12.824
ENSG00000144455 E008 0.0000000       3 3795239 3795295 57 -      
ENSG00000144455 E009 0.0000000       3 3795296 3795428 133 -      
ENSG00000144455 E010 0.1472490 0.0439030037 4.733872e-01   3 3797901 3798214 314 - 0.125 0.000 -11.826
ENSG00000144455 E011 0.0000000       3 3799712 3799896 185 -      
ENSG00000144455 E012 0.0000000       3 3800701 3800875 175 -      
ENSG00000144455 E013 0.2944980 0.3626087219 2.813796e-01   3 3822734 3822897 164 - 0.222 0.000 -12.824
ENSG00000144455 E014 0.8889039 0.3431476697 7.229522e-01 0.8169126547 3 3827242 3827509 268 - 0.302 0.221 -0.599
ENSG00000144455 E015 0.1515154 0.0445282856 4.728095e-01   3 4068052 4068093 42 - 0.125 0.000 -11.826
ENSG00000144455 E016 3.1104995 0.0076970389 8.610810e-01 0.9144117170 3 4068569 4068692 124 - 0.637 0.620 -0.076
ENSG00000144455 E017 3.3236259 0.0071650828 8.851680e-01 0.9305802412 3 4068693 4068745 53 - 0.637 0.621 -0.072
ENSG00000144455 E018 2.9685370 0.0236069266 2.190476e-01 0.3492443325 3 4351465 4351631 167 - 0.700 0.507 -0.856
ENSG00000144455 E019 158.9755560 0.0050090871 7.857121e-05 0.0004212202 3 4361146 4361711 566 - 2.106 2.272 0.555
ENSG00000144455 E020 54.7553385 0.0007762968 7.364015e-01 0.8268967179 3 4361712 4361765 54 - 1.754 1.747 -0.024
ENSG00000144455 E021 41.9836466 0.0077088759 9.766094e-01 0.9893835743 3 4361766 4361794 29 - 1.631 1.636 0.019
ENSG00000144455 E022 141.4398670 0.0005986328 1.913127e-01 0.3153785759 3 4361795 4362108 314 - 2.175 2.145 -0.100
ENSG00000144455 E023 96.8173472 0.0010638999 7.208091e-01 0.8153566817 3 4362109 4362254 146 - 1.999 1.994 -0.016
ENSG00000144455 E024 55.6041636 0.0004927772 7.360690e-01 0.8266661806 3 4376330 4376389 60 - 1.746 1.771 0.084
ENSG00000144455 E025 88.9347210 0.0003373506 1.801660e-01 0.3013799784 3 4410865 4410978 114 - 1.927 1.984 0.193
ENSG00000144455 E026 96.3263680 0.0002873412 4.917681e-01 0.6290380758 3 4417128 4417242 115 - 2.001 1.986 -0.050
ENSG00000144455 E027 83.8525050 0.0003471327 9.875315e-01 0.9962920811 3 4418010 4418132 123 - 1.927 1.934 0.026
ENSG00000144455 E028 64.9522898 0.0004736272 9.466738e-01 0.9705156838 3 4420064 4420146 83 - 1.820 1.826 0.019
ENSG00000144455 E029 56.3610537 0.0050755254 3.709420e-01 0.5153566037 3 4449266 4449340 75 - 1.786 1.740 -0.155
ENSG00000144455 E030 84.2359947 0.0012667100 1.198923e-02 0.0335064770 3 4452876 4453049 174 - 1.983 1.890 -0.312
ENSG00000144455 E031 55.1574944 0.0010484581 2.226129e-02 0.0562146480 3 4466976 4467273 298 - 1.804 1.703 -0.343