ENSG00000144401

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000406927 ENSG00000144401 HEK293_OSMI2_2hA HEK293_TMG_2hB METTL21A protein_coding protein_coding 13.4528 11.37817 16.15075 0.6714672 0.07637327 0.5049584 3.5063849 2.5288916 3.4337124 1.3976715 0.42398245 0.43976589 0.26050833 0.21910000 0.21276667 -0.006333333 0.9024571 0.0280402 FALSE  
ENST00000411432 ENSG00000144401 HEK293_OSMI2_2hA HEK293_TMG_2hB METTL21A protein_coding protein_coding 13.4528 11.37817 16.15075 0.6714672 0.07637327 0.5049584 1.8353016 1.6178770 2.2193294 0.5778161 0.26620991 0.45361816 0.14332917 0.13963333 0.13740000 -0.002233333 0.9693831 0.0280402 FALSE  
ENST00000432416 ENSG00000144401 HEK293_OSMI2_2hA HEK293_TMG_2hB METTL21A protein_coding protein_coding 13.4528 11.37817 16.15075 0.6714672 0.07637327 0.5049584 0.7177091 0.6204046 0.9159565 0.1339946 0.06701554 0.55466620 0.05414583 0.05510000 0.05666667 0.001566667 0.9786327 0.0280402 FALSE  
ENST00000442521 ENSG00000144401 HEK293_OSMI2_2hA HEK293_TMG_2hB METTL21A protein_coding protein_coding 13.4528 11.37817 16.15075 0.6714672 0.07637327 0.5049584 2.3264409 1.8743254 3.8778074 0.4921565 0.86898680 1.04490862 0.16505417 0.16756667 0.23973333 0.072166667 0.6609344 0.0280402 FALSE  
ENST00000448823 ENSG00000144401 HEK293_OSMI2_2hA HEK293_TMG_2hB METTL21A protein_coding protein_coding 13.4528 11.37817 16.15075 0.6714672 0.07637327 0.5049584 0.9242551 0.4558633 0.6548602 0.4558633 0.65486019 0.51314436 0.05992500 0.04353333 0.04090000 -0.002633333 0.9942058 0.0280402    
ENST00000477919 ENSG00000144401 HEK293_OSMI2_2hA HEK293_TMG_2hB METTL21A protein_coding processed_transcript 13.4528 11.37817 16.15075 0.6714672 0.07637327 0.5049584 0.9159300 0.7601254 1.3479353 0.1561845 0.00566124 0.81824941 0.07052917 0.06580000 0.08346667 0.017666667 0.6120569 0.0280402    
MSTRG.19878.11 ENSG00000144401 HEK293_OSMI2_2hA HEK293_TMG_2hB METTL21A protein_coding   13.4528 11.37817 16.15075 0.6714672 0.07637327 0.5049584 0.7242394 0.8065581 0.7896461 0.4043816 0.37679181 -0.03019386 0.05314583 0.07000000 0.04876667 -0.021233333 0.9944501 0.0280402 FALSE  
MSTRG.19878.7 ENSG00000144401 HEK293_OSMI2_2hA HEK293_TMG_2hB METTL21A protein_coding   13.4528 11.37817 16.15075 0.6714672 0.07637327 0.5049584 0.4727964 1.0073615 0.1847468 0.2078135 0.11586758 -2.38516085 0.04478750 0.08813333 0.01150000 -0.076633333 0.0280402 0.0280402 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000144401 E001 3.313006 0.0048692687 0.343474857 0.48751278 2 207580631 207580816 186 - 0.699 0.555 -0.628
ENSG00000144401 E002 4.388826 0.0036259291 0.399952074 0.54367436 2 207580817 207580940 124 - 0.789 0.672 -0.477
ENSG00000144401 E003 3.463185 0.0171967966 0.341630860 0.48554301 2 207580941 207580998 58 - 0.587 0.734 0.628
ENSG00000144401 E004 6.077495 0.0028225295 0.056710181 0.12096439 2 207581353 207581694 342 - 0.724 0.961 0.924
ENSG00000144401 E005 7.750092 0.0179972127 0.223424377 0.35447142 2 207581695 207581793 99 - 1.007 0.842 -0.622
ENSG00000144401 E006 7.238200 0.0273412752 0.551099029 0.68061343 2 207581794 207581800 7 - 0.955 0.864 -0.346
ENSG00000144401 E007 19.426460 0.0010015212 0.439134878 0.58091058 2 207581801 207581946 146 - 1.340 1.282 -0.204
ENSG00000144401 E008 10.773134 0.0128645393 0.104988998 0.19808241 2 207581947 207582160 214 - 1.151 0.977 -0.635
ENSG00000144401 E009 3.774733 0.0046274106 0.041254346 0.09334964 2 207597034 207597089 56 - 0.517 0.816 1.277
ENSG00000144401 E010 4.622762 0.0039843444 0.003531282 0.01181629 2 207597090 207597114 25 - 0.517 0.924 1.692
ENSG00000144401 E011 22.741532 0.0062763514 0.770120709 0.85155305 2 207609114 207609765 652 - 1.394 1.371 -0.080
ENSG00000144401 E012 3.442764 0.0046967728 0.490787688 0.62812960 2 207612068 207612103 36 - 0.699 0.598 -0.437
ENSG00000144401 E013 19.272281 0.0077248665 0.093312430 0.18029516 2 207612104 207612722 619 - 1.378 1.236 -0.498
ENSG00000144401 E014 6.843181 0.0167828197 0.044900235 0.10001781 2 207612723 207612726 4 - 1.006 0.736 -1.043
ENSG00000144401 E015 11.870331 0.0015077373 0.117794869 0.21678114 2 207612727 207612738 12 - 1.177 1.026 -0.543
ENSG00000144401 E016 13.022423 0.0013627160 0.199378131 0.32546283 2 207612739 207612742 4 - 1.201 1.083 -0.422
ENSG00000144401 E017 30.642205 0.0008922211 0.545840202 0.67611537 2 207612743 207612842 100 - 1.526 1.491 -0.123
ENSG00000144401 E018 47.566876 0.0005129842 0.725815606 0.81900512 2 207612843 207612979 137 - 1.686 1.704 0.061
ENSG00000144401 E019 38.617161 0.0005855291 0.857544400 0.91202613 2 207612980 207613026 47 - 1.598 1.608 0.036
ENSG00000144401 E020 158.459089 0.0002934557 0.557776351 0.68612706 2 207613027 207613443 417 - 2.212 2.197 -0.049
ENSG00000144401 E021 1.875689 0.0094397534 0.116720221 0.21527815 2 207615673 207615691 19 - 0.331 0.597 1.368
ENSG00000144401 E022 5.767472 0.0177113134 0.451533032 0.59247937 2 207620641 207620694 54 - 0.789 0.901 0.436
ENSG00000144401 E023 1.086531 0.4091998947 0.319476691 0.46255828 2 207620734 207620790 57 - 0.436 0.137 -2.217
ENSG00000144401 E024 83.652518 0.0003624588 0.089338431 0.17412088 2 207621806 207621917 112 - 1.901 1.964 0.210
ENSG00000144401 E025 95.783314 0.0003448047 0.038519613 0.08831127 2 207624229 207624404 176 - 1.955 2.026 0.235
ENSG00000144401 E026 1.921862 0.0098425104 0.478236410 0.61667781 2 207624405 207624566 162 - 0.517 0.395 -0.628
ENSG00000144401 E027 2.332502 0.0064597147 0.179570446 0.30060159 2 207624842 207624890 49 - 0.618 0.395 -1.088
ENSG00000144401 E028 3.060353 0.0056519940 0.217190076 0.34700408 2 207624891 207625061 171 - 0.699 0.508 -0.852
ENSG00000144401 E029 26.080303 0.0008217415 0.544924041 0.67533134 2 207625062 207625264 203 - 1.418 1.459 0.140
ENSG00000144401 E030 16.183002 0.0855955717 0.310488619 0.45290229 2 207625265 207625394 130 - 1.152 1.308 0.551
ENSG00000144401 E031 16.344515 0.0111583800 0.142364794 0.25126312 2 207625677 207625928 252 - 1.304 1.156 -0.523