ENSG00000144395

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000448409 ENSG00000144395 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC150 protein_coding nonsense_mediated_decay 6.82278 3.49564 8.008297 0.5453201 0.328991 1.193618 0.2281620 0.5123353 0.2148070 0.1020055 0.07010681 -1.2162894 0.04868750 0.1519000 0.02623333 -0.12566667 2.785009e-03 1.98326e-08 TRUE TRUE
MSTRG.19708.13 ENSG00000144395 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC150 protein_coding   6.82278 3.49564 8.008297 0.5453201 0.328991 1.193618 0.6586169 0.3278679 1.0113231 0.1705052 0.50671896 1.5959081 0.09485833 0.0880000 0.12616667 0.03816667 9.702633e-01 1.98326e-08 FALSE TRUE
MSTRG.19708.14 ENSG00000144395 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC150 protein_coding   6.82278 3.49564 8.008297 0.5453201 0.328991 1.193618 0.1133196 0.6131634 0.0000000 0.3175337 0.00000000 -5.9615386 0.02495417 0.1650000 0.00000000 -0.16500000 8.917138e-02 1.98326e-08 FALSE TRUE
MSTRG.19708.19 ENSG00000144395 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC150 protein_coding   6.82278 3.49564 8.008297 0.5453201 0.328991 1.193618 2.0179051 1.0837976 1.9523561 0.3187950 0.04269698 0.8432411 0.30313333 0.2998333 0.24426667 -0.05556667 6.439747e-01 1.98326e-08 TRUE TRUE
MSTRG.19708.4 ENSG00000144395 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC150 protein_coding   6.82278 3.49564 8.008297 0.5453201 0.328991 1.193618 0.2801139 0.0000000 0.4667332 0.0000000 0.46673320 5.5751102 0.03151667 0.0000000 0.06250000 0.06250000 9.669274e-01 1.98326e-08 FALSE TRUE
MSTRG.19708.6 ENSG00000144395 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC150 protein_coding   6.82278 3.49564 8.008297 0.5453201 0.328991 1.193618 0.7557949 0.0000000 0.8681552 0.0000000 0.05777415 6.4564040 0.09822083 0.0000000 0.10936667 0.10936667 1.983260e-08 1.98326e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000144395 E001 0.0000000       2 196639554 196639631 78 +      
ENSG00000144395 E002 1.0675023 0.0117078057 2.332543e-01 3.662818e-01 2 196639632 196639698 67 + 0.383 0.161 -1.652
ENSG00000144395 E003 1.0675023 0.0117078057 2.332543e-01 3.662818e-01 2 196639699 196639699 1 + 0.383 0.161 -1.652
ENSG00000144395 E004 1.2126750 0.0157187307 1.632541e-01 2.794060e-01 2 196639700 196639705 6 + 0.423 0.161 -1.874
ENSG00000144395 E005 1.3599240 0.0098022050 1.103603e-01 2.060658e-01 2 196639706 196639707 2 + 0.460 0.161 -2.067
ENSG00000144395 E006 1.3599240 0.0098022050 1.103603e-01 2.060658e-01 2 196639708 196639710 3 + 0.460 0.161 -2.067
ENSG00000144395 E007 1.3599240 0.0098022050 1.103603e-01 2.060658e-01 2 196639711 196639714 4 + 0.460 0.161 -2.067
ENSG00000144395 E008 1.3599240 0.0098022050 1.103603e-01 2.060658e-01 2 196639715 196639715 1 + 0.460 0.161 -2.067
ENSG00000144395 E009 1.8081276 0.0081290738 3.523719e-02 8.209834e-02 2 196639716 196639719 4 + 0.555 0.161 -2.527
ENSG00000144395 E010 3.5431006 0.0388446507 2.443847e-01 3.793350e-01 2 196639720 196639727 8 + 0.719 0.511 -0.916
ENSG00000144395 E011 14.3718105 0.0013016844 3.930792e-03 1.294797e-02 2 196639728 196639778 51 + 1.260 0.980 -1.009
ENSG00000144395 E012 15.0133874 0.0063469127 1.252089e-03 4.816532e-03 2 196646341 196646504 164 + 1.293 0.959 -1.200
ENSG00000144395 E013 20.3545811 0.0009535694 2.511805e-04 1.180281e-03 2 196656633 196656744 112 + 1.411 1.104 -1.081
ENSG00000144395 E014 22.9224121 0.0051545606 5.592353e-02 1.195611e-01 2 196656745 196656853 109 + 1.414 1.259 -0.541
ENSG00000144395 E015 0.6631923 0.4809633747 8.852235e-01 9.306076e-01 2 196656854 196656957 104 + 0.232 0.165 -0.606
ENSG00000144395 E016 32.0074374 0.0236678039 1.940213e-01 3.188365e-01 2 196656958 196657136 179 + 1.540 1.428 -0.385
ENSG00000144395 E017 0.0000000       2 196657137 196657429 293 +      
ENSG00000144395 E018 26.2493984 0.0108939300 4.247354e-01 5.676773e-01 2 196658792 196658860 69 + 1.438 1.375 -0.216
ENSG00000144395 E019 1.6284970 0.0088236250 7.652990e-01 8.481069e-01 2 196665567 196665683 117 + 0.423 0.371 -0.289
ENSG00000144395 E020 2.3865120 0.0152986850 5.291118e-01 6.619427e-01 2 196666719 196666848 130 + 0.555 0.447 -0.524
ENSG00000144395 E021 1.3284874 0.1148894807 9.202863e-01 9.536508e-01 2 196666849 196667934 1086 + 0.382 0.366 -0.093
ENSG00000144395 E022 15.4078853 0.0012245631 1.082908e-01 2.030052e-01 2 196669833 196669876 44 + 1.249 1.104 -0.516
ENSG00000144395 E023 13.2232978 0.0039993711 2.064748e-01 3.342936e-01 2 196672345 196672437 93 + 1.180 1.055 -0.448
ENSG00000144395 E024 25.7805767 0.0007816073 9.756742e-01 9.888274e-01 2 196674241 196674348 108 + 1.407 1.411 0.014
ENSG00000144395 E025 15.5852825 0.0011976605 2.419060e-01 3.764384e-01 2 196676143 196676168 26 + 1.237 1.133 -0.368
ENSG00000144395 E026 25.0452420 0.0008068841 3.278421e-01 4.713132e-01 2 196676169 196676267 99 + 1.422 1.354 -0.237
ENSG00000144395 E027 0.0000000       2 196676268 196676268 1 +      
ENSG00000144395 E028 30.2741141 0.0006307587 4.696793e-02 1.037708e-01 2 196676554 196676731 178 + 1.525 1.395 -0.448
ENSG00000144395 E029 10.8517820 0.0084926317 8.841999e-01 9.299805e-01 2 196677115 196677192 78 + 1.055 1.072 0.060
ENSG00000144395 E030 10.7254717 0.0421357889 6.081742e-01 7.280008e-01 2 196677293 196677305 13 + 1.027 1.093 0.242
ENSG00000144395 E031 15.2220329 0.0569268389 8.373725e-01 8.983369e-01 2 196677306 196677361 56 + 1.179 1.220 0.145
ENSG00000144395 E032 0.0000000       2 196695043 196695045 3 +      
ENSG00000144395 E033 4.9467026 0.0033219155 2.531394e-01 3.896178e-01 2 196695046 196695049 4 + 0.823 0.662 -0.653
ENSG00000144395 E034 12.9472636 0.0265962585 9.119410e-02 1.770001e-01 2 196695050 196695159 110 + 1.206 0.998 -0.750
ENSG00000144395 E035 22.8901762 0.0253577653 8.296431e-01 8.930357e-01 2 196701109 196701180 72 + 1.372 1.350 -0.079
ENSG00000144395 E036 24.7102831 0.0101529900 4.706726e-01 6.099051e-01 2 196712145 196712252 108 + 1.414 1.357 -0.200
ENSG00000144395 E037 1.2671776 0.0130848337 1.611164e-01 2.765744e-01 2 196712253 196712676 424 + 0.423 0.161 -1.874
ENSG00000144395 E038 0.1451727 0.0426191284 9.256927e-01   2 196712677 196712739 63 + 0.092 0.000 -9.393
ENSG00000144395 E039 0.0000000       2 196713099 196713116 18 +      
ENSG00000144395 E040 0.0000000       2 196713117 196713145 29 +      
ENSG00000144395 E041 3.0688593 0.0068239249 4.533217e-01 5.940610e-01 2 196713146 196713683 538 + 0.633 0.512 -0.551
ENSG00000144395 E042 0.5997190 0.1198146667 1.634878e-01 2.796929e-01 2 196718305 196718502 198 + 0.289 0.000 -11.396
ENSG00000144395 E043 22.7134929 0.0010169388 2.452887e-02 6.090888e-02 2 196718503 196718573 71 + 1.418 1.247 -0.599
ENSG00000144395 E044 23.2912195 0.0008850295 4.189684e-01 5.622343e-01 2 196718574 196718631 58 + 1.394 1.336 -0.202
ENSG00000144395 E045 0.0000000       2 196719279 196719290 12 +      
ENSG00000144395 E046 0.0000000       2 196719291 196719496 206 +      
ENSG00000144395 E047 30.7342264 0.0006431129 8.592879e-01 9.132190e-01 2 196719497 196719584 88 + 1.490 1.480 -0.033
ENSG00000144395 E048 29.4079487 0.0007153609 1.571634e-01 2.713226e-01 2 196719585 196719666 82 + 1.503 1.410 -0.319
ENSG00000144395 E049 1.9531985 0.0085310802 3.795479e-01 5.238197e-01 2 196719667 196719776 110 + 0.526 0.371 -0.806
ENSG00000144395 E050 1.7725238 0.0076983360 8.978197e-01 9.387702e-01 2 196720174 196720234 61 + 0.423 0.447 0.125
ENSG00000144395 E051 31.5036177 0.0014283062 6.737512e-01 7.793533e-01 2 196720575 196720668 94 + 1.506 1.481 -0.088
ENSG00000144395 E052 42.8889681 0.0030680472 5.282196e-01 6.611386e-01 2 196721522 196721691 170 + 1.640 1.604 -0.122
ENSG00000144395 E053 36.6600208 0.0012709523 4.612012e-01 6.011935e-01 2 196725973 196726099 127 + 1.543 1.589 0.155
ENSG00000144395 E054 11.8218388 0.0014608081 4.349782e-02 9.746601e-02 2 196726100 196728011 1912 + 1.166 0.959 -0.756
ENSG00000144395 E055 33.9993399 0.0014748030 4.172774e-02 9.423881e-02 2 196729193 196729387 195 + 1.477 1.603 0.434
ENSG00000144395 E056 38.9293871 0.0151478147 1.050228e-01 1.981209e-01 2 196729388 196729792 405 + 1.528 1.666 0.469
ENSG00000144395 E057 24.5685009 0.0007551461 8.206627e-02 1.627844e-01 2 196729793 196729861 69 + 1.337 1.461 0.428
ENSG00000144395 E058 42.2379988 0.0006023342 3.480691e-03 1.166843e-02 2 196729957 196730118 162 + 1.552 1.711 0.541
ENSG00000144395 E059 21.8209375 0.0023407361 1.969619e-01 3.224256e-01 2 196730859 196730862 4 + 1.303 1.403 0.348
ENSG00000144395 E060 38.6759883 0.0130367882 4.646966e-02 1.028835e-01 2 196730863 196730945 83 + 1.513 1.674 0.548
ENSG00000144395 E061 33.8367047 0.0011809049 3.393163e-03 1.141825e-02 2 196732033 196732096 64 + 1.441 1.623 0.622
ENSG00000144395 E062 39.0064377 0.0014606495 1.597491e-05 1.013292e-04 2 196732097 196732152 56 + 1.463 1.716 0.862
ENSG00000144395 E063 1.0706228 0.0118860767 7.430003e-01 8.317625e-01 2 196732426 196732445 20 + 0.338 0.278 -0.390
ENSG00000144395 E064 56.1371428 0.0033286176 3.858944e-06 2.817751e-05 2 196732446 196732801 356 + 1.628 1.875 0.835
ENSG00000144395 E065 1.5802339 0.0088010158 5.198497e-02 1.126987e-01 2 196762298 196762483 186 + 0.232 0.568 1.934
ENSG00000144395 E066 1.9293377 0.0073552556 4.825405e-01 6.206774e-01 2 196763255 196763490 236 + 0.494 0.371 -0.652