ENSG00000144357

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000272793 ENSG00000144357 HEK293_OSMI2_2hA HEK293_TMG_2hB UBR3 protein_coding protein_coding 7.521257 1.925493 11.01995 0.1557593 0.4584839 2.510653 3.00521327 0.3548936 5.6768806 0.1776172 0.16172383 3.962090 0.32491250 0.18113333 0.5173000 0.336166667 0.19340343 0.04653165 FALSE TRUE
ENST00000392632 ENSG00000144357 HEK293_OSMI2_2hA HEK293_TMG_2hB UBR3 protein_coding protein_coding 7.521257 1.925493 11.01995 0.1557593 0.4584839 2.510653 0.39826154 0.6086760 0.0000000 0.3269821 0.00000000 -5.951112 0.15949167 0.31413333 0.0000000 -0.314133333 0.04653165 0.04653165 FALSE TRUE
ENST00000444475 ENSG00000144357 HEK293_OSMI2_2hA HEK293_TMG_2hB UBR3 protein_coding nonsense_mediated_decay 7.521257 1.925493 11.01995 0.1557593 0.4584839 2.510653 0.22654482 0.4448544 0.1250732 0.2510822 0.06616965 -1.751663 0.07867917 0.21806667 0.0109000 -0.207166667 0.24533613 0.04653165 FALSE TRUE
MSTRG.19461.4 ENSG00000144357 HEK293_OSMI2_2hA HEK293_TMG_2hB UBR3 protein_coding   7.521257 1.925493 11.01995 0.1557593 0.4584839 2.510653 0.09295649 0.1076960 0.0000000 0.1076960 0.00000000 -3.556993 0.03669583 0.06026667 0.0000000 -0.060266667 0.47669307 0.04653165 FALSE TRUE
MSTRG.19461.5 ENSG00000144357 HEK293_OSMI2_2hA HEK293_TMG_2hB UBR3 protein_coding   7.521257 1.925493 11.01995 0.1557593 0.4584839 2.510653 1.17320690 0.1146670 0.7722013 0.1146670 0.11582981 2.649460 0.10602083 0.06416667 0.0710000 0.006833333 0.62100250 0.04653165 FALSE TRUE
MSTRG.19461.6 ENSG00000144357 HEK293_OSMI2_2hA HEK293_TMG_2hB UBR3 protein_coding   7.521257 1.925493 11.01995 0.1557593 0.4584839 2.510653 2.05174094 0.2240137 3.3058278 0.2240137 0.40430769 3.824704 0.21472500 0.12780000 0.2995667 0.171766667 0.25251477 0.04653165 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000144357 E001 0.4482035 0.0264746281 1.000000e+00 1.000000e+00 2 169827370 169827453 84 + 0.133 0.000 -10.980
ENSG00000144357 E002 15.1652286 0.0041535561 1.390518e-04 6.994385e-04 2 169827454 169827759 306 + 1.113 0.442 -2.760
ENSG00000144357 E003 5.6365055 0.0052879146 3.084738e-03 1.051542e-02 2 169827760 169827771 12 + 0.744 0.000 -14.333
ENSG00000144357 E004 8.6360768 0.0020163072 1.726251e-02 4.553065e-02 2 169827772 169827848 77 + 0.887 0.442 -1.923
ENSG00000144357 E005 22.0778162 0.0125366692 8.497307e-05 4.515411e-04 2 169827849 169828052 204 + 1.264 0.656 -2.296
ENSG00000144357 E006 35.8489876 0.0026574231 1.733237e-05 1.090414e-04 2 169872236 169872375 140 + 1.457 0.993 -1.645
ENSG00000144357 E007 19.2337973 0.0010803512 8.308347e-03 2.456444e-02 2 169875791 169875793 3 + 1.193 0.857 -1.239
ENSG00000144357 E008 44.3101904 0.0368165246 1.382126e-02 3.782171e-02 2 169875794 169875949 156 + 1.533 1.232 -1.044
ENSG00000144357 E009 34.1025482 0.0005935989 8.459408e-04 3.422990e-03 2 169877494 169877637 144 + 1.425 1.097 -1.156
ENSG00000144357 E010 34.5390072 0.0006019638 1.566867e-02 4.199867e-02 2 169878525 169878574 50 + 1.421 1.205 -0.756
ENSG00000144357 E011 36.1638084 0.0005789083 1.754737e-03 6.455195e-03 2 169891165 169891231 67 + 1.446 1.154 -1.022
ENSG00000144357 E012 36.0266917 0.0005724646 1.105370e-04 5.704101e-04 2 169895181 169895311 131 + 1.452 1.065 -1.363
ENSG00000144357 E013 50.3149446 0.0019400301 2.825342e-03 9.749947e-03 2 169896507 169896735 229 + 1.581 1.347 -0.805
ENSG00000144357 E014 54.8507495 0.0008940198 3.371388e-04 1.528977e-03 2 169905114 169905293 180 + 1.620 1.347 -0.939
ENSG00000144357 E015 45.0402640 0.0005207778 4.680255e-02 1.034706e-01 2 169906031 169906164 134 + 1.526 1.380 -0.502
ENSG00000144357 E016 32.1147088 0.0041354569 9.915358e-01 9.987956e-01 2 169914060 169914146 87 + 1.365 1.380 0.055
ENSG00000144357 E017 31.0259762 0.0007427191 6.420531e-01 7.549362e-01 2 169923929 169923994 66 + 1.356 1.329 -0.091
ENSG00000144357 E018 41.9960341 0.0058265848 2.934523e-02 7.067229e-02 2 169924084 169924173 90 + 1.502 1.311 -0.660
ENSG00000144357 E019 50.2940503 0.0847677547 8.522876e-02 1.677785e-01 2 169925619 169925747 129 + 1.582 1.340 -0.834
ENSG00000144357 E020 39.9501725 0.0206139739 4.036566e-03 1.324503e-02 2 169926692 169926744 53 + 1.493 1.155 -1.178
ENSG00000144357 E021 55.5526517 0.0041741146 2.880200e-05 1.720844e-04 2 169926838 169926971 134 + 1.633 1.272 -1.245
ENSG00000144357 E022 47.0118495 0.0054448340 5.527793e-05 3.080432e-04 2 169927320 169927405 86 + 1.565 1.180 -1.336
ENSG00000144357 E023 52.2840815 0.0309465272 1.150530e-01 2.129120e-01 2 169928727 169928860 134 + 1.593 1.437 -0.534
ENSG00000144357 E024 22.8963124 0.0105892982 2.903156e-01 4.311076e-01 2 169928861 169928868 8 + 1.241 1.127 -0.406
ENSG00000144357 E025 36.8133689 0.0007345572 4.295334e-01 5.722491e-01 2 169932912 169933008 97 + 1.431 1.380 -0.177
ENSG00000144357 E026 45.8938287 0.0053670568 1.983818e-02 5.114494e-02 2 169942493 169942634 142 + 1.541 1.346 -0.672
ENSG00000144357 E027 21.5164207 0.0134884236 1.334408e-02 3.672117e-02 2 169946288 169946309 22 + 1.238 0.906 -1.206
ENSG00000144357 E028 36.3192329 0.0006101726 1.203361e-01 2.204662e-01 2 169946310 169946392 83 + 1.433 1.311 -0.424
ENSG00000144357 E029 0.1515154 0.0428635133 7.743036e-01   2 169947409 169947541 133 + 0.049 0.000 -9.106
ENSG00000144357 E030 51.7421922 0.0004223965 1.120527e-01 2.085598e-01 2 169947542 169947715 174 + 1.581 1.480 -0.347
ENSG00000144357 E031 0.7512344 0.2780994913 7.987024e-01 8.715513e-01 2 169949482 169949604 123 + 0.205 0.000 -11.464
ENSG00000144357 E032 85.1951111 0.0003428026 2.724078e-01 4.112852e-01 2 169949605 169950065 461 + 1.785 1.740 -0.153
ENSG00000144357 E033 38.2566480 0.0005886126 2.950138e-01 4.361255e-01 2 169958438 169958526 89 + 1.452 1.380 -0.248
ENSG00000144357 E034 0.8846520 0.0136545923 7.540096e-01 8.397546e-01 2 169964393 169964538 146 + 0.204 0.275 0.562
ENSG00000144357 E035 37.9361587 0.0005407430 4.354204e-01 5.776633e-01 2 169986645 169986733 89 + 1.427 1.504 0.265
ENSG00000144357 E036 36.2200115 0.0005661542 5.006013e-01 6.368389e-01 2 169986734 169986794 61 + 1.409 1.480 0.242
ENSG00000144357 E037 51.3631745 0.0004736045 6.050422e-01 7.254693e-01 2 169994323 169994456 134 + 1.570 1.550 -0.069
ENSG00000144357 E038 39.8961216 0.0030520754 2.041326e-01 3.313426e-01 2 170001304 170001372 69 + 1.473 1.380 -0.323
ENSG00000144357 E039 30.8295221 0.0048679771 3.755702e-01 5.199969e-01 2 170001373 170001414 42 + 1.362 1.291 -0.247
ENSG00000144357 E040 60.6402613 0.0043951950 7.857354e-01 8.627437e-01 2 170006990 170007190 201 + 1.630 1.664 0.117
ENSG00000144357 E041 6.9564080 0.0242309725 4.808465e-01 6.190659e-01 2 170007191 170007202 12 + 0.780 0.658 -0.503
ENSG00000144357 E042 21.7558341 0.0036852429 1.371042e-01 2.440567e-01 2 170008804 170008839 36 + 1.183 1.347 0.574
ENSG00000144357 E043 31.7104812 0.0006832649 4.919099e-01 6.291535e-01 2 170008840 170008940 101 + 1.351 1.426 0.259
ENSG00000144357 E044 2.4161639 0.0128021233 4.733463e-01 6.122949e-01 2 170013841 170013972 132 + 0.408 0.562 0.767
ENSG00000144357 E045 0.7363589 0.0155889093 6.365089e-01 7.505163e-01 2 170014040 170014439 400 + 0.204 0.000 -11.419
ENSG00000144357 E046 0.3686942 0.0302302968 1.564407e-01 2.703781e-01 2 170014803 170014814 12 + 0.049 0.276 2.888
ENSG00000144357 E047 0.9514613 0.0599939061 7.456230e-01 8.336148e-01 2 170014815 170014865 51 + 0.204 0.276 0.571
ENSG00000144357 E048 2.0241605 0.0073373740 2.888398e-01 4.294803e-01 2 170014866 170015280 415 + 0.342 0.563 1.148
ENSG00000144357 E049 36.6285116 0.0005964851 8.630749e-01 9.157009e-01 2 170015281 170015366 86 + 1.423 1.426 0.008
ENSG00000144357 E050 0.2987644 0.0273076747 1.000000e+00   2 170016833 170016919 87 + 0.093 0.000 -10.102
ENSG00000144357 E051 24.0398811 0.0024396453 3.799108e-01 5.241793e-01 2 170029346 170029350 5 + 1.258 1.180 -0.275
ENSG00000144357 E052 42.7633255 0.0005213582 6.774767e-01 7.821827e-01 2 170029351 170029448 98 + 1.480 1.528 0.163
ENSG00000144357 E053 51.4785439 0.0026456157 2.620525e-01 3.997735e-01 2 170040882 170040985 104 + 1.552 1.647 0.323
ENSG00000144357 E054 57.7423071 0.0004492931 1.547280e-01 2.680612e-01 2 170055460 170055584 125 + 1.597 1.703 0.361
ENSG00000144357 E055 51.6492140 0.0022734927 8.477279e-03 2.498009e-02 2 170061079 170061186 108 + 1.534 1.726 0.653
ENSG00000144357 E056 56.9985149 0.0023217823 4.106873e-03 1.344267e-02 2 170061318 170061443 126 + 1.574 1.774 0.676
ENSG00000144357 E057 0.2903454 0.3389689091 1.000000e+00   2 170073404 170073427 24 + 0.093 0.000 -10.145
ENSG00000144357 E058 71.1614273 0.0027322391 1.435449e-04 7.189277e-04 2 170073428 170073607 180 + 1.664 1.900 0.798
ENSG00000144357 E059 78.1838261 0.0024108112 2.290782e-07 2.171646e-06 2 170079814 170080023 210 + 1.690 1.984 0.990
ENSG00000144357 E060 0.8899626 0.0426352946 1.940448e-01 3.188642e-01 2 170080024 170080544 521 + 0.170 0.441 1.877
ENSG00000144357 E061 57.8146874 0.0004046347 4.043089e-06 2.937267e-05 2 170080545 170080684 140 + 1.563 1.845 0.956
ENSG00000144357 E062 272.4378144 0.0037369488 5.598546e-22 4.448942e-20 2 170081726 170084131 2406 + 2.210 2.564 1.183