ENSG00000144354

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000306721 ENSG00000144354 HEK293_OSMI2_2hA HEK293_TMG_2hB CDCA7 protein_coding protein_coding 46.37124 34.20284 52.25361 3.407034 1.117088 0.6112688 5.7358128 2.45003198 8.4575357 0.60848885 0.8729355 1.7832651 0.11530417 0.07486667 0.16236667 0.08750000 8.465818e-02 1.01415e-46 FALSE TRUE
ENST00000347703 ENSG00000144354 HEK293_OSMI2_2hA HEK293_TMG_2hB CDCA7 protein_coding protein_coding 46.37124 34.20284 52.25361 3.407034 1.117088 0.6112688 22.2638704 19.24449695 24.2974659 1.57710172 1.4303198 0.3362041 0.49272083 0.56626667 0.46656667 -0.09970000 3.204906e-01 1.01415e-46 FALSE TRUE
ENST00000410019 ENSG00000144354 HEK293_OSMI2_2hA HEK293_TMG_2hB CDCA7 protein_coding protein_coding 46.37124 34.20284 52.25361 3.407034 1.117088 0.6112688 0.8553703 3.31241604 0.0000000 0.25600675 0.0000000 -8.3760889 0.02526667 0.09746667 0.00000000 -0.09746667 1.014150e-46 1.01415e-46 FALSE TRUE
ENST00000496441 ENSG00000144354 HEK293_OSMI2_2hA HEK293_TMG_2hB CDCA7 protein_coding retained_intron 46.37124 34.20284 52.25361 3.407034 1.117088 0.6112688 8.7950492 2.22907309 9.2855610 0.50135530 0.2176527 2.0536403 0.18454583 0.06650000 0.17783333 0.11133333 9.751516e-04 1.01415e-46 FALSE TRUE
ENST00000695914 ENSG00000144354 HEK293_OSMI2_2hA HEK293_TMG_2hB CDCA7 protein_coding protein_coding 46.37124 34.20284 52.25361 3.407034 1.117088 0.6112688 2.8273809 0.08530201 3.1533894 0.08530201 2.4642891 5.0528207 0.04622917 0.00210000 0.05883333 0.05673333 4.958994e-01 1.01415e-46 FALSE TRUE
ENST00000695918 ENSG00000144354 HEK293_OSMI2_2hA HEK293_TMG_2hB CDCA7 protein_coding processed_transcript 46.37124 34.20284 52.25361 3.407034 1.117088 0.6112688 1.6286714 4.33463928 0.1843127 2.25446225 0.0925752 -4.4827843 0.04657917 0.11743333 0.00360000 -0.11383333 4.249982e-01 1.01415e-46   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000144354 E001 1.223170 0.0114545764 8.724599e-02 1.709608e-01 2 173354820 173354839 20 + 0.442 0.152 -2.078
ENSG00000144354 E002 5.946136 0.0117539762 6.939495e-02 1.423616e-01 2 173354840 173354852 13 + 0.921 0.714 -0.811
ENSG00000144354 E003 20.901206 0.0066283408 5.384737e-02 1.159849e-01 2 173354853 173354871 19 + 1.380 1.260 -0.420
ENSG00000144354 E004 29.974212 0.0041686915 1.319323e-02 3.635940e-02 2 173354872 173354887 16 + 1.536 1.403 -0.456
ENSG00000144354 E005 35.656265 0.0011482916 5.156535e-03 1.635455e-02 2 173354888 173354892 5 + 1.607 1.482 -0.426
ENSG00000144354 E006 122.784648 0.0002856266 7.645458e-05 4.112696e-04 2 173354893 173354963 71 + 2.121 2.039 -0.274
ENSG00000144354 E007 127.409444 0.0002858706 2.519734e-04 1.183479e-03 2 173354964 173354984 21 + 2.134 2.065 -0.231
ENSG00000144354 E008 0.732103 0.1041987642 1.768898e-01 2.972120e-01 2 173358507 173358711 205 + 0.098 0.356 2.328
ENSG00000144354 E009 93.921615 0.0003360406 2.460391e-05 1.495104e-04 2 173358712 173358714 3 + 2.019 1.908 -0.370
ENSG00000144354 E010 249.724812 0.0002942657 1.348102e-12 3.234881e-11 2 173358715 173358837 123 + 2.442 2.321 -0.402
ENSG00000144354 E011 41.181592 0.0005570053 2.118819e-06 1.638985e-05 2 173359255 173359342 88 + 1.701 1.476 -0.769
ENSG00000144354 E012 35.586923 0.0006086090 3.588388e-10 5.768918e-09 2 173359343 173359386 44 + 1.677 1.324 -1.210
ENSG00000144354 E013 44.513387 0.0004978760 5.927934e-07 5.169295e-06 2 173359387 173359491 105 + 1.735 1.505 -0.782
ENSG00000144354 E014 404.954718 0.0022742853 3.729342e-05 2.165423e-04 2 173363226 173363462 237 + 2.633 2.562 -0.237
ENSG00000144354 E015 226.499780 0.0001968365 3.005722e-02 7.206909e-02 2 173363818 173363895 78 + 2.356 2.353 -0.010
ENSG00000144354 E016 39.802096 0.0005829255 7.576632e-13 1.896380e-11 2 173363896 173363999 104 + 1.729 1.333 -1.356
ENSG00000144354 E017 71.650985 0.0049054851 6.210709e-06 4.328133e-05 2 173364000 173364161 162 + 1.930 1.722 -0.703
ENSG00000144354 E018 126.343333 0.0141897306 2.913485e-07 2.703522e-06 2 173364162 173364794 633 + 2.201 1.897 -1.020
ENSG00000144354 E019 343.089682 0.0001471034 4.240275e-04 1.866420e-03 2 173364795 173364939 145 + 2.542 2.523 -0.063
ENSG00000144354 E020 261.358666 0.0002626353 3.318970e-02 7.817786e-02 2 173364940 173364989 50 + 2.415 2.416 0.003
ENSG00000144354 E021 4.373616 0.0447475995 4.810018e-02 1.058072e-01 2 173364990 173365061 72 + 0.834 0.543 -1.223
ENSG00000144354 E022 410.758877 0.0002859672 1.680711e-01 2.856886e-01 2 173365452 173365592 141 + 2.602 2.626 0.080
ENSG00000144354 E023 13.541266 0.0017657116 7.105798e-13 1.786085e-11 2 173365593 173366282 690 + 1.347 0.546 -3.078
ENSG00000144354 E024 370.979587 0.0006771684 7.674998e-01 8.497191e-01 2 173366283 173366432 150 + 2.549 2.591 0.140
ENSG00000144354 E025 329.842962 0.0001724587 1.056049e-02 3.011308e-02 2 173367150 173367286 137 + 2.472 2.572 0.332
ENSG00000144354 E026 396.479485 0.0001680742 7.118053e-05 3.858682e-04 2 173367634 173367831 198 + 2.541 2.662 0.400
ENSG00000144354 E027 1277.597556 0.0033041149 8.629311e-21 6.077313e-19 2 173367832 173368997 1166 + 2.971 3.235 0.880
ENSG00000144354 E028 1.247017 0.0242230383 3.817270e-01 5.260415e-01 2 173383179 173383181 3 + 0.401 0.264 -0.854
ENSG00000144354 E029 3.960293 0.0992986902 1.991837e-01 3.252071e-01 2 173383182 173383324 143 + 0.781 0.544 -1.012