ENSG00000144320

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000272748 ENSG00000144320 HEK293_OSMI2_2hA HEK293_TMG_2hB LNPK protein_coding protein_coding 14.66618 2.473133 20.88408 0.17138 0.4598121 3.072861 5.198679 1.5614294 7.143161 0.3068961 0.1603998 2.186503 0.45328333 0.65453333 0.3423667 -0.31216667 5.542810e-01 2.967248e-06 FALSE TRUE
ENST00000409660 ENSG00000144320 HEK293_OSMI2_2hA HEK293_TMG_2hB LNPK protein_coding protein_coding 14.66618 2.473133 20.88408 0.17138 0.4598121 3.072861 5.988876 0.6367624 8.596337 0.3278747 0.7563637 3.734092 0.36477500 0.24143333 0.4106667 0.16923333 6.508372e-01 2.967248e-06 FALSE TRUE
MSTRG.19546.5 ENSG00000144320 HEK293_OSMI2_2hA HEK293_TMG_2hB LNPK protein_coding   14.66618 2.473133 20.88408 0.17138 0.4598121 3.072861 1.453419 0.0000000 2.096627 0.0000000 0.3161296 7.718791 0.06005000 0.00000000 0.1001000 0.10010000 2.967248e-06 2.967248e-06 FALSE TRUE
MSTRG.19546.6 ENSG00000144320 HEK293_OSMI2_2hA HEK293_TMG_2hB LNPK protein_coding   14.66618 2.473133 20.88408 0.17138 0.4598121 3.072861 0.996018 0.2080302 1.373241 0.1446929 0.5811281 2.665452 0.05795833 0.07713333 0.0664000 -0.01073333 1.000000e+00 2.967248e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000144320 E001 0.7813216 0.0388217053 2.792817e-02 6.787132e-02 2 175923882 175923896 15 - 0.101 0.534 3.206
ENSG00000144320 E002 546.9054785 0.0072783325 1.043811e-04 5.421959e-04 2 175923897 175929172 5276 - 2.573 2.760 0.623
ENSG00000144320 E003 188.0456379 0.0094912870 7.783800e-02 1.560062e-01 2 175929173 175929859 687 - 2.120 2.260 0.470
ENSG00000144320 E004 71.4282752 0.0013922405 6.472308e-01 7.589451e-01 2 175929860 175929938 79 - 1.717 1.796 0.268
ENSG00000144320 E005 43.0837963 0.0004917042 7.413897e-01 8.305829e-01 2 175929939 175929945 7 - 1.513 1.544 0.106
ENSG00000144320 E006 49.5521467 0.0016865736 6.083609e-01 7.281122e-01 2 175929946 175929968 23 - 1.562 1.650 0.299
ENSG00000144320 E007 123.6134235 0.0006308897 8.139123e-01 8.820557e-01 2 175929969 175930199 231 - 1.955 2.019 0.215
ENSG00000144320 E008 0.5891098 0.0183346401 6.293533e-01 7.447396e-01 2 175932088 175932162 75 - 0.183 0.000 -12.105
ENSG00000144320 E009 84.2349091 0.0003340398 2.254586e-01 3.569604e-01 2 175937344 175937467 124 - 1.803 1.796 -0.026
ENSG00000144320 E010 32.7212605 0.0006320811 1.423473e-01 2.512369e-01 2 175937468 175937477 10 - 1.413 1.343 -0.242
ENSG00000144320 E011 40.1335189 0.0005564091 5.042584e-01 6.401543e-01 2 175937478 175937514 37 - 1.486 1.490 0.016
ENSG00000144320 E012 0.3666179 0.0336805840 2.161422e-01 3.457586e-01 2 175937515 175937856 342 - 0.053 0.258 2.631
ENSG00000144320 E013 64.9767212 0.0004418277 2.090576e-02 5.339157e-02 2 175938313 175938383 71 - 1.704 1.617 -0.295
ENSG00000144320 E014 0.1451727 0.0437135845 1.000000e+00   2 175938384 175938807 424 - 0.053 0.000 -10.105
ENSG00000144320 E015 76.1022301 0.0003942538 6.184143e-04 2.601171e-03 2 175939552 175939657 106 - 1.779 1.634 -0.493
ENSG00000144320 E016 0.2966881 0.0270134877 1.000000e+00   2 175939658 175939754 97 - 0.101 0.000 -11.106
ENSG00000144320 E017 1.8436020 0.0074003048 4.658772e-01 6.054760e-01 2 175940988 175941080 93 - 0.387 0.258 -0.831
ENSG00000144320 E018 109.6548786 0.0003042144 6.626497e-06 4.588508e-05 2 175947480 175947692 213 - 1.939 1.773 -0.561
ENSG00000144320 E019 50.8690202 0.0004223303 1.668394e-03 6.181134e-03 2 175964372 175964423 52 - 1.613 1.442 -0.586
ENSG00000144320 E020 62.1634392 0.0004055091 8.574243e-02 1.685758e-01 2 175964506 175964589 84 - 1.684 1.634 -0.169
ENSG00000144320 E021 49.7832627 0.0004470283 3.262903e-01 4.697443e-01 2 175970764 175970804 41 - 1.583 1.573 -0.036
ENSG00000144320 E022 56.2513746 0.0005220363 7.293984e-02 1.482246e-01 2 175979810 175979868 59 - 1.643 1.582 -0.207
ENSG00000144320 E023 37.7633649 0.0013344509 2.838886e-01 4.240851e-01 2 175992231 175992238 8 - 1.470 1.442 -0.098
ENSG00000144320 E024 48.4561935 0.0013498796 6.193960e-01 7.368340e-01 2 175992239 175992273 35 - 1.568 1.591 0.076
ENSG00000144320 E025 74.4129525 0.0003481263 1.858030e-01 3.085132e-01 2 175992274 175992418 145 - 1.753 1.735 -0.060
ENSG00000144320 E026 0.1515154 0.0434488045 1.000000e+00   2 175993181 175993181 1 - 0.053 0.000 -10.106
ENSG00000144320 E027 42.1015278 0.0005151948 3.938542e-01 5.377543e-01 2 175993182 175993223 42 - 1.509 1.502 -0.026
ENSG00000144320 E028 1.7842814 0.0097713393 9.121165e-02 1.770251e-01 2 175994134 175994144 11 - 0.410 0.000 -13.691
ENSG00000144320 E029 5.0596998 0.0031316397 2.778451e-01 4.174751e-01 2 175994145 175994280 136 - 0.693 0.535 -0.694
ENSG00000144320 E030 0.4375944 0.0272882053 1.000000e+00 1.000000e+00 2 175995553 175995557 5 - 0.144 0.000 -11.690
ENSG00000144320 E031 52.0542830 0.0004467519 8.733714e-03 2.562096e-02 2 175995558 175995646 89 - 1.618 1.490 -0.435
ENSG00000144320 E032 32.3022628 0.0006411560 1.196973e-01 2.195423e-01 2 176002160 176002294 135 - 1.406 1.327 -0.276
ENSG00000144320 E033 0.1472490 0.0444626507 1.000000e+00   2 176002512 176002839 328 - 0.053 0.000 -10.106