ENSG00000144306

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000272732 ENSG00000144306 HEK293_OSMI2_2hA HEK293_TMG_2hB SCRN3 protein_coding protein_coding 12.48353 4.162386 20.57858 0.4920885 0.2753458 2.3029 3.9774736 0.7923874 7.3754558 0.13882645 0.17053040 3.20231607 0.28737500 0.19460000 0.35840000 0.16380000 7.678901e-03 3.928734e-11 FALSE TRUE
ENST00000435964 ENSG00000144306 HEK293_OSMI2_2hA HEK293_TMG_2hB SCRN3 protein_coding protein_coding 12.48353 4.162386 20.57858 0.4920885 0.2753458 2.3029 1.2567753 0.2743549 2.0607807 0.27435489 0.33983391 2.86441027 0.08937083 0.05703333 0.09990000 0.04286667 3.508439e-01 3.928734e-11   FALSE
ENST00000458563 ENSG00000144306 HEK293_OSMI2_2hA HEK293_TMG_2hB SCRN3 protein_coding protein_coding 12.48353 4.162386 20.57858 0.4920885 0.2753458 2.3029 0.8199733 0.3673372 1.3014941 0.19217146 0.33957257 1.79728508 0.05434167 0.07866667 0.06343333 -0.01523333 9.974267e-01 3.928734e-11 FALSE TRUE
ENST00000490927 ENSG00000144306 HEK293_OSMI2_2hA HEK293_TMG_2hB SCRN3 protein_coding processed_transcript 12.48353 4.162386 20.57858 0.4920885 0.2753458 2.3029 3.0199622 1.1738860 4.9701457 0.01622545 0.64899194 2.07265773 0.23792083 0.29186667 0.24246667 -0.04940000 7.419457e-01 3.928734e-11 FALSE TRUE
ENST00000548031 ENSG00000144306 HEK293_OSMI2_2hA HEK293_TMG_2hB SCRN3 protein_coding protein_coding 12.48353 4.162386 20.57858 0.4920885 0.2753458 2.3029 1.3027469 0.2808923 1.6741505 0.28089231 0.42272439 2.53346397 0.10867500 0.06266667 0.08086667 0.01820000 4.509033e-01 3.928734e-11 FALSE TRUE
ENST00000549848 ENSG00000144306 HEK293_OSMI2_2hA HEK293_TMG_2hB SCRN3 protein_coding processed_transcript 12.48353 4.162386 20.57858 0.4920885 0.2753458 2.3029 0.6853093 0.7798105 0.8218155 0.09372683 0.08025999 0.07475691 0.08120000 0.18730000 0.03993333 -0.14736667 3.928734e-11 3.928734e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000144306 E001 0.2214452 0.0386154998 0.0904126557   2 174395730 174395740 11 + 0.000 0.229 10.736
ENSG00000144306 E002 2.1400746 0.0179834899 0.7636771554 0.846942116 2 174395741 174395742 2 + 0.428 0.488 0.305
ENSG00000144306 E003 3.9502786 0.0041326044 0.7105978300 0.807728113 2 174395743 174395744 2 + 0.640 0.576 -0.279
ENSG00000144306 E004 5.3853292 0.0031628227 0.7809190088 0.859233148 2 174395745 174395751 7 + 0.723 0.767 0.180
ENSG00000144306 E005 19.4730179 0.0009593124 0.1377183779 0.244900345 2 174395752 174395791 40 + 1.254 1.106 -0.527
ENSG00000144306 E006 19.9116565 0.0009273483 0.1753573545 0.295131835 2 174395792 174395794 3 + 1.262 1.129 -0.470
ENSG00000144306 E007 22.1323864 0.0008361672 0.0930005491 0.179811755 2 174395795 174395807 13 + 1.310 1.151 -0.560
ENSG00000144306 E008 23.5404703 0.0007954282 0.0766286390 0.154100799 2 174395808 174395817 10 + 1.335 1.172 -0.575
ENSG00000144306 E009 8.8881122 0.0019965702 0.5979371777 0.719624395 2 174395818 174395946 129 + 0.929 0.859 -0.265
ENSG00000144306 E010 8.1712315 0.0020873866 0.4137832523 0.557190349 2 174395947 174395989 43 + 0.861 0.969 0.407
ENSG00000144306 E011 15.4657043 0.0026779423 0.9705137475 0.985558778 2 174395990 174396231 242 + 1.131 1.130 -0.007
ENSG00000144306 E012 8.5767761 0.0019413051 0.6842368657 0.787251591 2 174396232 174396293 62 + 0.913 0.859 -0.204
ENSG00000144306 E013 5.1379825 0.0034618046 0.0303320676 0.072621472 2 174397336 174397404 69 + 0.624 0.936 1.248
ENSG00000144306 E014 1.4154839 0.3975422829 0.7792321494 0.858023002 2 174398195 174398274 80 + 0.318 0.380 0.373
ENSG00000144306 E015 37.7729149 0.0006224176 0.0923928609 0.178850382 2 174398275 174398365 91 + 1.524 1.402 -0.418
ENSG00000144306 E016 43.6317454 0.0005380488 0.0161333969 0.043028827 2 174398366 174398442 77 + 1.592 1.426 -0.570
ENSG00000144306 E017 77.5406385 0.0004130581 0.0187249863 0.048733943 2 174399922 174400103 182 + 1.830 1.712 -0.398
ENSG00000144306 E018 89.9458812 0.0007574863 0.3988878201 0.542644288 2 174400990 174401189 200 + 1.879 1.843 -0.124
ENSG00000144306 E019 87.8253326 0.0003644397 0.8764983519 0.924740691 2 174404103 174404315 213 + 1.859 1.868 0.030
ENSG00000144306 E020 1.8885647 0.0081150050 0.2133776141 0.342513187 2 174410037 174410081 45 + 0.347 0.576 1.180
ENSG00000144306 E021 3.9105326 0.0041369548 0.0081419007 0.024143167 2 174410082 174410225 144 + 0.497 0.899 1.695
ENSG00000144306 E022 4.0362418 0.0101042915 0.5369753288 0.668644523 2 174410226 174410343 118 + 0.608 0.712 0.443
ENSG00000144306 E023 6.8612865 0.0025638636 0.0008345089 0.003382222 2 174410344 174410503 160 + 0.683 1.107 1.625
ENSG00000144306 E024 76.4908037 0.0003684130 0.3445463332 0.488638209 2 174422885 174423047 163 + 1.791 1.838 0.158
ENSG00000144306 E025 90.9640046 0.0003741390 0.1470169866 0.257621051 2 174424475 174424649 175 + 1.861 1.925 0.217
ENSG00000144306 E026 245.6058518 0.0005498080 0.0215979149 0.054846521 2 174427713 174429575 1863 + 2.290 2.349 0.197