ENSG00000144283

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000389757 ENSG00000144283 HEK293_OSMI2_2hA HEK293_TMG_2hB PKP4 protein_coding protein_coding 24.75842 14.63187 30.50649 0.4406023 1.250625 1.059489 4.4223480 3.0846004 5.047461 1.6380267 0.3895153 0.7086601 0.19938750 0.21780000 0.16606667 -0.05173333 9.784188e-01 1.438269e-46 FALSE TRUE
ENST00000452162 ENSG00000144283 HEK293_OSMI2_2hA HEK293_TMG_2hB PKP4 protein_coding nonsense_mediated_decay 24.75842 14.63187 30.50649 0.4406023 1.250625 1.059489 5.2943018 0.0000000 8.504172 0.0000000 0.5024779 9.7337225 0.16649167 0.00000000 0.27906667 0.27906667 1.438269e-46 1.438269e-46 FALSE TRUE
ENST00000483881 ENSG00000144283 HEK293_OSMI2_2hA HEK293_TMG_2hB PKP4 protein_coding retained_intron 24.75842 14.63187 30.50649 0.4406023 1.250625 1.059489 2.6063770 1.3994056 3.358404 0.1600961 0.7289819 1.2569783 0.10730000 0.09646667 0.10843333 0.01196667 9.020400e-01 1.438269e-46 FALSE FALSE
MSTRG.19379.19 ENSG00000144283 HEK293_OSMI2_2hA HEK293_TMG_2hB PKP4 protein_coding   24.75842 14.63187 30.50649 0.4406023 1.250625 1.059489 0.7118211 1.4103846 0.000000 1.4103846 0.0000000 -7.1501378 0.04072083 0.09170000 0.00000000 -0.09170000 7.071985e-01 1.438269e-46 FALSE TRUE
MSTRG.19379.23 ENSG00000144283 HEK293_OSMI2_2hA HEK293_TMG_2hB PKP4 protein_coding   24.75842 14.63187 30.50649 0.4406023 1.250625 1.059489 1.5703483 0.8364628 2.212360 0.8364628 0.1527508 1.3925738 0.06521250 0.06036667 0.07316667 0.01280000 2.848088e-01 1.438269e-46 FALSE TRUE
MSTRG.19379.24 ENSG00000144283 HEK293_OSMI2_2hA HEK293_TMG_2hB PKP4 protein_coding   24.75842 14.63187 30.50649 0.4406023 1.250625 1.059489 0.5123761 2.1282151 0.000000 0.7525892 0.0000000 -7.7402632 0.03284167 0.14440000 0.00000000 -0.14440000 3.233594e-10 1.438269e-46 FALSE TRUE
MSTRG.19379.37 ENSG00000144283 HEK293_OSMI2_2hA HEK293_TMG_2hB PKP4 protein_coding   24.75842 14.63187 30.50649 0.4406023 1.250625 1.059489 0.2085396 0.7844592 0.000000 0.4561067 0.0000000 -6.3119013 0.01316667 0.05183333 0.00000000 -0.05183333 7.781900e-02 1.438269e-46 FALSE TRUE
MSTRG.19379.7 ENSG00000144283 HEK293_OSMI2_2hA HEK293_TMG_2hB PKP4 protein_coding   24.75842 14.63187 30.50649 0.4406023 1.250625 1.059489 2.1672133 0.0000000 3.411076 0.0000000 1.0591435 8.4183065 0.07643750 0.00000000 0.11050000 0.11050000 1.404408e-10 1.438269e-46 FALSE TRUE
MSTRG.19379.9 ENSG00000144283 HEK293_OSMI2_2hA HEK293_TMG_2hB PKP4 protein_coding   24.75842 14.63187 30.50649 0.4406023 1.250625 1.059489 2.0332990 1.9577651 2.516081 1.0334145 1.3110270 0.3603431 0.08015833 0.13103333 0.08336667 -0.04766667 9.580322e-01 1.438269e-46 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000144283 E001 0.4418608 0.0251308418 1.599786e-01 2.750923e-01 2 158456952 158456963 12 + 0.248 0.000 -10.240
ENSG00000144283 E002 1.2407877 0.4386872831 6.212697e-01 7.382522e-01 2 158456964 158457098 135 + 0.403 0.263 -0.881
ENSG00000144283 E003 2.8294155 0.0499758790 7.077462e-01 8.055441e-01 2 158457099 158457108 10 + 0.582 0.545 -0.172
ENSG00000144283 E004 3.1981097 0.1213032895 8.331684e-01 8.954719e-01 2 158457109 158457109 1 + 0.610 0.600 -0.046
ENSG00000144283 E005 3.3496252 0.0800144821 6.992175e-01 7.990244e-01 2 158457110 158457110 1 + 0.637 0.597 -0.176
ENSG00000144283 E006 3.7872196 0.0826899207 4.487607e-01 5.900217e-01 2 158457111 158457111 1 + 0.708 0.597 -0.473
ENSG00000144283 E007 4.3773736 0.0088319702 2.479578e-01 3.835171e-01 2 158457112 158457113 2 + 0.769 0.634 -0.560
ENSG00000144283 E008 4.3773736 0.0088319702 2.479578e-01 3.835171e-01 2 158457114 158457115 2 + 0.769 0.634 -0.560
ENSG00000144283 E009 11.6835444 0.0532556033 1.604706e-01 2.757581e-01 2 158457116 158457132 17 + 1.157 0.992 -0.597
ENSG00000144283 E010 13.3495061 0.0524156436 1.028807e-01 1.948674e-01 2 158457133 158457135 3 + 1.222 1.027 -0.700
ENSG00000144283 E011 40.5900788 0.0166360698 6.418406e-04 2.686940e-03 2 158457136 158457218 83 + 1.704 1.453 -0.856
ENSG00000144283 E012 2.0597618 0.0085055945 1.839305e-01 3.061608e-01 2 158457455 158457867 413 + 0.552 0.350 -1.052
ENSG00000144283 E013 3.0164330 0.0179149231 2.102758e-01 3.388636e-01 2 158457868 158458192 325 + 0.662 0.487 -0.798
ENSG00000144283 E014 2.4136055 0.1157999370 9.919799e-01 9.990889e-01 2 158458193 158458307 115 + 0.519 0.543 0.112
ENSG00000144283 E015 0.0000000       2 158458308 158458331 24 +      
ENSG00000144283 E016 35.0081105 0.0006527312 4.830739e-06 3.452295e-05 2 158533180 158533184 5 + 1.642 1.404 -0.817
ENSG00000144283 E017 93.3841205 0.0012841405 1.052179e-09 1.554004e-08 2 158533185 158533316 132 + 2.047 1.837 -0.705
ENSG00000144283 E018 1.2492067 0.0146141607 3.553486e-01 4.997013e-01 2 158533438 158533534 97 + 0.405 0.261 -0.900
ENSG00000144283 E019 77.0740027 0.0009059041 1.507055e-13 4.175300e-12 2 158577271 158577340 70 + 1.987 1.700 -0.967
ENSG00000144283 E020 66.2123474 0.0004072179 9.769718e-12 2.039048e-10 2 158577341 158577383 43 + 1.920 1.651 -0.910
ENSG00000144283 E021 0.1472490 0.0428758217 6.884238e-01   2 158578169 158578263 95 + 0.099 0.000 -8.652
ENSG00000144283 E022 2.9761289 0.0746605492 3.149447e-02 7.486992e-02 2 158588225 158588285 61 + 0.730 0.347 -1.839
ENSG00000144283 E023 2.9761289 0.0746605492 3.149447e-02 7.486992e-02 2 158588888 158588956 69 + 0.730 0.347 -1.839
ENSG00000144283 E024 74.4510495 0.0005030034 2.051620e-10 3.430177e-09 2 158603070 158603104 35 + 1.957 1.724 -0.785
ENSG00000144283 E025 144.2359725 0.0003114972 4.907184e-15 1.689968e-13 2 158620990 158621115 126 + 2.232 2.033 -0.667
ENSG00000144283 E026 43.5668030 0.0005230741 3.311148e-03 1.117999e-02 2 158621116 158621121 6 + 1.695 1.581 -0.387
ENSG00000144283 E027 187.1905497 0.0002255390 6.754063e-12 1.446458e-10 2 158621231 158621421 191 + 2.327 2.189 -0.462
ENSG00000144283 E028 103.1299490 0.0003369405 1.730410e-05 1.088853e-04 2 158624878 158624954 77 + 2.061 1.952 -0.363
ENSG00000144283 E029 155.7041147 0.0007913521 4.204381e-07 3.776527e-06 2 158624955 158625124 170 + 2.236 2.121 -0.384
ENSG00000144283 E030 228.7303452 0.0010572139 1.881329e-07 1.811936e-06 2 158625125 158625427 303 + 2.397 2.296 -0.338
ENSG00000144283 E031 155.3520645 0.0002615426 2.690426e-04 1.253703e-03 2 158631753 158631941 189 + 2.216 2.156 -0.201
ENSG00000144283 E032 0.0000000       2 158632474 158632642 169 +      
ENSG00000144283 E033 39.2425566 0.0013424107 4.014408e-01 5.451426e-01 2 158634070 158634072 3 + 1.600 1.595 -0.014
ENSG00000144283 E034 119.7265929 0.0003929118 6.628348e-02 1.371922e-01 2 158634073 158634153 81 + 2.086 2.071 -0.051
ENSG00000144283 E035 149.3955135 0.0006424284 8.314961e-02 1.644975e-01 2 158634154 158634289 136 + 2.178 2.170 -0.028
ENSG00000144283 E036 107.5563936 0.0016043980 2.184670e-01 3.485621e-01 2 158640627 158640759 133 + 2.035 2.032 -0.009
ENSG00000144283 E037 78.9726519 0.0041000501 3.032174e-02 7.260041e-02 2 158642486 158642519 34 + 1.928 1.865 -0.213
ENSG00000144283 E038 166.2125282 0.0011982481 1.940261e-02 5.020579e-02 2 158642520 158642699 180 + 2.234 2.205 -0.096
ENSG00000144283 E039 189.3854054 0.0002529469 7.931862e-01 8.677763e-01 2 158658131 158658314 184 + 2.253 2.306 0.176
ENSG00000144283 E040 162.9123620 0.0012947419 9.188260e-01 9.527316e-01 2 158661333 158661450 118 + 2.188 2.235 0.158
ENSG00000144283 E041 3.5032304 0.0050369416 6.680640e-01 7.751364e-01 2 158661451 158661764 314 + 0.662 0.633 -0.123
ENSG00000144283 E042 6.1280649 0.0715700709 5.444026e-01 6.748774e-01 2 158662242 158662896 655 + 0.871 0.808 -0.246
ENSG00000144283 E043 153.4129017 0.0002824266 1.232842e-01 2.246551e-01 2 158662897 158662989 93 + 2.143 2.233 0.302
ENSG00000144283 E044 111.2788014 0.0002953364 3.462209e-01 4.903707e-01 2 158662990 158663057 68 + 2.012 2.090 0.260
ENSG00000144283 E045 89.0419085 0.0022875659 1.851860e-01 3.077234e-01 2 158663058 158663088 31 + 1.908 2.012 0.351
ENSG00000144283 E046 181.0943706 0.0015423448 1.357236e-02 3.724334e-02 2 158663272 158663445 174 + 2.201 2.324 0.411
ENSG00000144283 E047 173.6555827 0.0034342133 2.723171e-02 6.645925e-02 2 158666413 158666563 151 + 2.179 2.307 0.427
ENSG00000144283 E048 4.2718545 0.0036573217 4.251741e-01 5.681194e-01 2 158666564 158666659 96 + 0.750 0.673 -0.316
ENSG00000144283 E049 4.3701645 0.0707326735 3.081446e-01 4.503987e-01 2 158669151 158669169 19 + 0.788 0.632 -0.645
ENSG00000144283 E050 14.8857590 0.0401773368 1.774206e-01 2.978976e-01 2 158669170 158669719 550 + 1.254 1.111 -0.509
ENSG00000144283 E051 208.5486883 0.0001990866 1.163089e-02 3.265367e-02 2 158669720 158669915 196 + 2.269 2.377 0.362
ENSG00000144283 E052 150.4769758 0.0002707401 1.667481e-03 6.177872e-03 2 158673677 158673761 85 + 2.114 2.251 0.460
ENSG00000144283 E053 206.5496856 0.0039480668 7.293499e-03 2.198459e-02 2 158673883 158674000 118 + 2.244 2.395 0.502
ENSG00000144283 E054 47.3892864 0.0004490554 2.097418e-03 7.526131e-03 2 158676739 158676867 129 + 1.585 1.787 0.684
ENSG00000144283 E055 8.7138493 0.0247408860 6.298675e-01 7.451573e-01 2 158676868 158677355 488 + 0.999 0.982 -0.066
ENSG00000144283 E056 165.2849495 0.0051459549 2.830355e-03 9.765288e-03 2 158678581 158678654 74 + 2.133 2.311 0.596
ENSG00000144283 E057 772.6747279 0.0049343846 1.612003e-16 6.764423e-15 2 158680429 158682879 2451 + 2.725 3.034 1.026