ENSG00000144278

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000392825 ENSG00000144278 HEK293_OSMI2_2hA HEK293_TMG_2hB GALNT13 protein_coding protein_coding 10.29903 2.724569 15.91565 0.2592412 0.2519794 2.541967 3.57472976 1.1208185 6.9327381 0.4262169 0.5840414 2.6181374 0.38552083 0.44556667 0.436433333 -0.009133333 1.0000000000 1.13692e-05 FALSE TRUE
ENST00000409237 ENSG00000144278 HEK293_OSMI2_2hA HEK293_TMG_2hB GALNT13 protein_coding protein_coding 10.29903 2.724569 15.91565 0.2592412 0.2519794 2.541967 0.08413075 0.1623974 0.1217520 0.1101639 0.1217520 -0.3879136 0.01462500 0.06513333 0.007466667 -0.057666667 0.3913514544 1.13692e-05 FALSE TRUE
ENST00000487047 ENSG00000144278 HEK293_OSMI2_2hA HEK293_TMG_2hB GALNT13 protein_coding processed_transcript 10.29903 2.724569 15.91565 0.2592412 0.2519794 2.541967 1.72957563 0.0000000 1.6850747 0.0000000 0.3447056 7.4052050 0.10034167 0.00000000 0.106533333 0.106533333 0.0000113692 1.13692e-05 FALSE FALSE
MSTRG.19355.1 ENSG00000144278 HEK293_OSMI2_2hA HEK293_TMG_2hB GALNT13 protein_coding   10.29903 2.724569 15.91565 0.2592412 0.2519794 2.541967 0.85734311 0.2587187 1.8319048 0.1391241 0.1522353 2.7770297 0.07268333 0.09040000 0.114866667 0.024466667 0.7885241556 1.13692e-05 FALSE TRUE
MSTRG.19355.3 ENSG00000144278 HEK293_OSMI2_2hA HEK293_TMG_2hB GALNT13 protein_coding   10.29903 2.724569 15.91565 0.2592412 0.2519794 2.541967 2.12712084 0.3540926 4.4678621 0.3070403 0.4252028 3.6204328 0.16235417 0.11216667 0.280033333 0.167866667 0.2940501171 1.13692e-05 FALSE TRUE
MSTRG.19355.6 ENSG00000144278 HEK293_OSMI2_2hA HEK293_TMG_2hB GALNT13 protein_coding   10.29903 2.724569 15.91565 0.2592412 0.2519794 2.541967 1.54144138 0.6339271 0.3838023 0.3520651 0.2597807 -0.7094258 0.20823750 0.21586667 0.023866667 -0.192000000 0.4959656923 1.13692e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000144278 E001 2.1392711 0.1075772477 7.269585e-01 8.198455e-01 2 153871914 153871921 8 + 0.456 0.375 -0.434
ENSG00000144278 E002 12.7571475 0.0014009563 3.031410e-01 4.450354e-01 2 153871922 153871951 30 + 1.078 0.965 -0.417
ENSG00000144278 E003 14.3802452 0.0012526947 6.995222e-01 7.992208e-01 2 153871952 153871952 1 + 1.111 1.078 -0.119
ENSG00000144278 E004 18.2872246 0.0059807618 3.332362e-01 4.769264e-01 2 153871953 153871977 25 + 1.221 1.125 -0.340
ENSG00000144278 E005 24.7629614 0.0008160619 1.250488e-01 2.272042e-01 2 153871978 153872027 50 + 1.352 1.224 -0.448
ENSG00000144278 E006 34.3185124 0.0006279037 1.607237e-03 5.984635e-03 2 153872028 153872176 149 + 1.506 1.258 -0.859
ENSG00000144278 E007 28.4204334 0.0037910928 1.460057e-04 7.299397e-04 2 153872177 153872303 127 + 1.443 1.078 -1.287
ENSG00000144278 E008 34.7115552 0.0010538371 2.086425e-02 5.329994e-02 2 153900936 153901007 72 + 1.504 1.333 -0.590
ENSG00000144278 E009 0.6017953 0.1562114364 5.115090e-01 6.465227e-01 2 153926288 153926339 52 + 0.210 0.001 -8.497
ENSG00000144278 E010 51.3128214 0.0005552697 9.604946e-02 1.844380e-01 2 153944394 153944497 104 + 1.657 1.564 -0.318
ENSG00000144278 E011 76.0604398 0.0004484562 4.451952e-02 9.931573e-02 2 153944498 153944639 142 + 1.823 1.730 -0.314
ENSG00000144278 E012 35.5629209 0.0007229004 1.654759e-01 2.823184e-01 2 154140337 154140340 4 + 1.502 1.409 -0.320
ENSG00000144278 E013 86.4715790 0.0003212285 2.867906e-02 6.936534e-02 2 154140341 154140505 165 + 1.877 1.782 -0.320
ENSG00000144278 E014 0.9557277 0.0139424769 9.224425e-01 9.550702e-01 2 154236046 154236180 135 + 0.249 0.227 -0.173
ENSG00000144278 E015 81.7529396 0.0019651188 5.176022e-01 6.519479e-01 2 154242030 154242196 167 + 1.836 1.812 -0.083
ENSG00000144278 E016 94.7320833 0.0018626346 9.998203e-01 1.000000e+00 2 154242698 154242905 208 + 1.895 1.905 0.033
ENSG00000144278 E017 89.3158805 0.0003493570 1.586052e-02 4.242468e-02 2 154245812 154245982 171 + 1.847 1.961 0.384
ENSG00000144278 E018 0.0000000       2 154257567 154257725 159 +      
ENSG00000144278 E019 78.7123445 0.0003866892 2.267093e-03 8.051554e-03 2 154259021 154259138 118 + 1.782 1.931 0.501
ENSG00000144278 E020 81.1884706 0.0003860090 3.157643e-01 4.585395e-01 2 154301409 154301578 170 + 1.818 1.875 0.192
ENSG00000144278 E021 26.3156072 0.0008588234 5.787893e-01 7.037910e-01 2 154301579 154301589 11 + 1.343 1.397 0.189
ENSG00000144278 E022 1.8551416 0.0076648552 8.500703e-01 9.069970e-01 2 154364368 154364545 178 + 0.406 0.375 -0.174
ENSG00000144278 E023 66.0910160 0.0004297916 6.595625e-01 7.683452e-01 2 154395991 154396130 140 + 1.744 1.730 -0.045
ENSG00000144278 E024 35.8414237 0.0010580220 4.539324e-03 1.465186e-02 2 154408984 154409010 27 + 1.521 1.305 -0.745
ENSG00000144278 E025 52.3991199 0.0004813151 2.417730e-02 6.017312e-02 2 154409011 154409082 72 + 1.670 1.539 -0.447
ENSG00000144278 E026 0.6244956 0.0614223099 1.727556e-01 2.917812e-01 2 154409083 154409340 258 + 0.117 0.374 2.144
ENSG00000144278 E027 47.6928354 0.0004458840 3.955398e-01 5.393445e-01 2 154438592 154438653 62 + 1.615 1.572 -0.147
ENSG00000144278 E028 51.7268875 0.0004888542 5.869936e-01 7.104010e-01 2 154438654 154438726 73 + 1.646 1.624 -0.075
ENSG00000144278 E029 0.9117205 0.0503487055 9.296004e-01 9.596597e-01 2 154441721 154441812 92 + 0.249 0.227 -0.172
ENSG00000144278 E030 0.3729606 0.0315418796 2.846759e-01 4.249299e-01 2 154446478 154446567 90 + 0.062 0.227 2.151
ENSG00000144278 E031 5.0531681 0.0046656416 8.608713e-01 9.142520e-01 2 154446568 154446597 30 + 0.727 0.708 -0.076
ENSG00000144278 E032 9.2283416 0.0021383733 6.302705e-01 7.454572e-01 2 154446598 154446765 168 + 0.949 0.895 -0.203
ENSG00000144278 E033 467.2925485 0.0012287599 4.757573e-07 4.225343e-06 2 154450411 154453979 3569 + 2.558 2.669 0.370