ENSG00000144233

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000393001 ENSG00000144233 HEK293_OSMI2_2hA HEK293_TMG_2hB AMMECR1L protein_coding protein_coding 15.62267 12.83411 17.98436 1.161646 0.2613178 0.4864374 12.387755 11.130822 13.716768 1.0274297 0.4207271 0.3011363 0.79694583 0.8674667 0.7625333 -0.1049333 0.007217408 0.007217408 FALSE TRUE
ENST00000679574 ENSG00000144233 HEK293_OSMI2_2hA HEK293_TMG_2hB AMMECR1L protein_coding nonsense_mediated_decay 15.62267 12.83411 17.98436 1.161646 0.2613178 0.4864374 1.300158 1.023456 1.811419 0.1511656 0.3660232 0.8175861 0.08369583 0.0802000 0.1007000 0.0205000 0.761365382 0.007217408 TRUE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000144233 E001 0.8824740 0.1130657229 8.384395e-01 8.990192e-01 2 127861630 127861636 7 - 0.248 0.345 0.658
ENSG00000144233 E002 1.8015814 0.0267155639 8.725274e-01 9.220086e-01 2 127861637 127861638 2 - 0.447 0.484 0.189
ENSG00000144233 E003 5.6401198 0.0399789487 9.625975e-01 9.803891e-01 2 127861639 127861644 6 - 0.788 0.876 0.345
ENSG00000144233 E004 7.8876209 0.0296569863 8.239096e-02 1.632851e-01 2 127861645 127861648 4 - 0.788 1.108 1.203
ENSG00000144233 E005 11.0628533 0.0491685875 1.568526e-01 2.709120e-01 2 127861649 127861653 5 - 0.940 1.224 1.033
ENSG00000144233 E006 940.1885409 0.0069874041 1.852520e-12 4.345646e-11 2 127861654 127863680 2027 - 2.823 3.110 0.955
ENSG00000144233 E007 281.0908884 0.0004428808 1.055340e-02 3.009834e-02 2 127863681 127864080 400 - 2.379 2.527 0.494
ENSG00000144233 E008 312.1090446 0.0022210529 6.695208e-02 1.383071e-01 2 127864081 127864664 584 - 2.477 2.514 0.125
ENSG00000144233 E009 120.1465772 0.0024698254 4.190034e-03 1.367824e-02 2 127864665 127864829 165 - 2.090 2.067 -0.078
ENSG00000144233 E010 203.1484461 0.0002650382 1.334477e-09 1.932375e-08 2 127864830 127865205 376 - 2.331 2.272 -0.197
ENSG00000144233 E011 3.0416760 0.0226981376 5.727662e-01 6.988427e-01 2 127865683 127865810 128 - 0.611 0.589 -0.097
ENSG00000144233 E012 1.1124400 0.0116475451 4.173004e-01 5.606672e-01 2 127865906 127865981 76 - 0.359 0.261 -0.640
ENSG00000144233 E013 93.8200462 0.0044124787 1.073334e-02 3.053060e-02 2 127866900 127866996 97 - 1.989 1.953 -0.118
ENSG00000144233 E014 1.4509834 0.6353985243 7.510954e-01 8.376273e-01 2 127866997 127867017 21 - 0.362 0.420 0.328
ENSG00000144233 E015 5.0982551 0.0143615428 4.180539e-01 5.613673e-01 2 127867145 127867279 135 - 0.806 0.773 -0.131
ENSG00000144233 E016 75.4645223 0.0065260461 6.740551e-03 2.054975e-02 2 127869454 127869540 87 - 1.907 1.843 -0.214
ENSG00000144233 E017 37.9674288 0.0040980276 5.438332e-04 2.323905e-03 2 127869541 127869544 4 - 1.640 1.504 -0.464
ENSG00000144233 E018 3.9211443 0.0040420049 1.119550e-01 2.084262e-01 2 127870762 127870813 52 - 0.750 0.589 -0.681
ENSG00000144233 E019 74.3093581 0.0004834476 2.855293e-07 2.654594e-06 2 127870814 127870928 115 - 1.926 1.804 -0.411
ENSG00000144233 E020 3.8591410 0.0185339109 5.690207e-02 1.212945e-01 2 127870929 127870957 29 - 0.769 0.541 -0.980
ENSG00000144233 E021 75.1967534 0.0006260625 1.631033e-07 1.590704e-06 2 127871249 127871359 111 - 1.933 1.806 -0.428
ENSG00000144233 E022 7.3290656 0.0190541982 1.251800e-04 6.374823e-04 2 127872986 127873077 92 - 1.062 0.590 -1.865
ENSG00000144233 E023 192.8158901 0.0013132806 3.939692e-15 1.377053e-13 2 127873828 127874272 445 - 2.343 2.198 -0.484
ENSG00000144233 E024 67.8776728 0.0038001585 1.167637e-07 1.171452e-06 2 127884203 127884312 110 - 1.908 1.719 -0.636
ENSG00000144233 E025 0.5911862 0.0184731256 6.675360e-02 1.379964e-01 2 127884758 127884860 103 - 0.307 0.000 -11.956
ENSG00000144233 E026 0.3729606 0.0336127948 8.475435e-01 9.053302e-01 2 127885480 127885809 330 - 0.099 0.150 0.685
ENSG00000144233 E027 47.4191072 0.0085469273 2.387934e-06 1.826719e-05 2 127885810 127886934 1125 - 1.770 1.530 -0.814
ENSG00000144233 E028 0.0000000       2 127886935 127887388 454 -      
ENSG00000144233 E029 0.0000000       2 127887389 127888767 1379 -