ENSG00000144136

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000272542 ENSG00000144136 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC20A1 protein_coding protein_coding 76.39266 69.69624 81.68301 5.935805 0.6920219 0.2289247 71.34533 67.69449 75.21045 5.635102 1.318 0.1518733 0.9344458 0.9716333 0.9206 -0.05103333 5.20721e-05 5.20721e-05 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000144136 E001 269.4327331 0.0043903484 1.943336e-10 3.262377e-09 2 112645939 112646129 191 + 2.526 2.318 -0.694
ENSG00000144136 E002 933.6463744 0.0016443727 1.353512e-15 5.032752e-14 2 112646563 112647162 600 + 3.034 2.902 -0.441
ENSG00000144136 E003 451.7909226 0.0021710928 1.018613e-04 5.305103e-04 2 112647324 112647446 123 + 2.690 2.623 -0.224
ENSG00000144136 E004 222.8044238 0.0091185091 1.996057e-02 5.140273e-02 2 112647447 112647464 18 + 2.391 2.306 -0.283
ENSG00000144136 E005 0.6611159 0.0331794808 3.451768e-01 4.892514e-01 2 112647623 112647652 30 + 0.280 0.131 -1.365
ENSG00000144136 E006 314.6306496 0.0071690995 3.054966e-02 7.304826e-02 2 112647653 112647701 49 + 2.529 2.470 -0.198
ENSG00000144136 E007 199.2220432 0.0024464263 1.470663e-03 5.541553e-03 2 112647702 112647703 2 + 2.337 2.269 -0.226
ENSG00000144136 E008 245.5864215 0.0023840034 2.163920e-03 7.732129e-03 2 112647704 112647717 14 + 2.423 2.365 -0.193
ENSG00000144136 E009 256.4952284 0.0029005982 9.886493e-03 2.848401e-02 2 112647718 112647738 21 + 2.436 2.390 -0.154
ENSG00000144136 E010 1.5605418 0.0108549019 5.768425e-01 7.022028e-01 2 112651946 112652072 127 + 0.449 0.380 -0.371
ENSG00000144136 E011 5.2904047 0.0050438132 9.339460e-03 2.713116e-02 2 112652270 112652701 432 + 0.932 0.619 -1.259
ENSG00000144136 E012 452.4738431 0.0021038869 4.173491e-05 2.394982e-04 2 112652702 112652798 97 + 2.693 2.622 -0.236
ENSG00000144136 E013 11.1801867 0.0015224013 1.920448e-03 6.978883e-03 2 112652889 112652947 59 + 1.207 0.940 -0.969
ENSG00000144136 E014 17.7488077 0.0021496805 1.220098e-06 9.944667e-06 2 112652948 112653355 408 + 1.421 1.048 -1.318
ENSG00000144136 E015 503.6680682 0.0006953546 4.723389e-09 6.193037e-08 2 112657122 112657241 120 + 2.741 2.666 -0.247
ENSG00000144136 E016 13.3944666 0.0013063141 1.711369e-02 4.519289e-02 2 112658363 112658824 462 + 1.238 1.061 -0.632
ENSG00000144136 E017 497.3461188 0.0001460940 3.558735e-12 7.975789e-11 2 112658825 112658950 126 + 2.734 2.665 -0.231
ENSG00000144136 E018 284.8577629 0.0005629027 1.236631e-05 8.042612e-05 2 112658951 112658973 23 + 2.489 2.431 -0.194
ENSG00000144136 E019 520.1306899 0.0001135402 3.481485e-03 1.167089e-02 2 112658974 112659094 121 + 2.721 2.720 -0.005
ENSG00000144136 E020 2.9745261 0.0874854345 8.947094e-01 9.367146e-01 2 112659095 112659203 109 + 0.604 0.615 0.047
ENSG00000144136 E021 1557.3491641 0.0002547685 9.146780e-01 9.499827e-01 2 112659204 112659762 559 + 3.173 3.217 0.148
ENSG00000144136 E022 956.4849227 0.0003743242 1.694006e-04 8.325750e-04 2 112660387 112660572 186 + 2.933 3.029 0.320
ENSG00000144136 E023 5.9075599 0.0058978757 7.777597e-01 8.569947e-01 2 112660573 112661141 569 + 0.809 0.884 0.291
ENSG00000144136 E024 659.3226748 0.0004043479 2.623125e-06 1.989763e-05 2 112661142 112661226 85 + 2.758 2.878 0.401
ENSG00000144136 E025 2599.2223850 0.0045000774 1.635901e-15 6.014293e-14 2 112662864 112663825 962 + 3.269 3.521 0.838