ENSG00000144134

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000409121 ENSG00000144134 HEK293_OSMI2_2hA HEK293_TMG_2hB RABL2A protein_coding retained_intron 12.35614 13.44851 10.48245 0.5616019 0.1796491 -0.3591665 1.4267469 0.7846713 1.5852420 0.29436673 0.07125553 1.0053451 0.11640000 0.05893333 0.15153333 0.092600000 8.074522e-02 5.173949e-17 FALSE TRUE
ENST00000409842 ENSG00000144134 HEK293_OSMI2_2hA HEK293_TMG_2hB RABL2A protein_coding protein_coding 12.35614 13.44851 10.48245 0.5616019 0.1796491 -0.3591665 2.2933518 3.1416997 1.5511430 0.26586343 0.20705810 -1.0135274 0.18259167 0.23440000 0.14750000 -0.086900000 9.475224e-02 5.173949e-17 FALSE TRUE
ENST00000465711 ENSG00000144134 HEK293_OSMI2_2hA HEK293_TMG_2hB RABL2A protein_coding processed_transcript 12.35614 13.44851 10.48245 0.5616019 0.1796491 -0.3591665 0.8561354 0.4049044 0.7738608 0.02592797 0.10573903 0.9178187 0.06975417 0.03030000 0.07360000 0.043300000 1.079234e-02 5.173949e-17 FALSE TRUE
ENST00000467600 ENSG00000144134 HEK293_OSMI2_2hA HEK293_TMG_2hB RABL2A protein_coding retained_intron 12.35614 13.44851 10.48245 0.5616019 0.1796491 -0.3591665 1.0876646 0.5212427 1.3573550 0.13731263 0.19599699 1.3639448 0.08895417 0.03953333 0.12970000 0.090166667 1.049361e-02 5.173949e-17 FALSE FALSE
ENST00000493876 ENSG00000144134 HEK293_OSMI2_2hA HEK293_TMG_2hB RABL2A protein_coding retained_intron 12.35614 13.44851 10.48245 0.5616019 0.1796491 -0.3591665 1.7068706 1.9111551 1.1213642 0.31099513 0.07478543 -0.7639106 0.13552500 0.14233333 0.10730000 -0.035033333 5.697654e-01 5.173949e-17   FALSE
ENST00000494909 ENSG00000144134 HEK293_OSMI2_2hA HEK293_TMG_2hB RABL2A protein_coding retained_intron 12.35614 13.44851 10.48245 0.5616019 0.1796491 -0.3591665 0.9027745 0.8548091 0.7472050 0.15698690 0.02477470 -0.1916976 0.07300833 0.06433333 0.07136667 0.007033333 8.657691e-01 5.173949e-17 FALSE TRUE
ENST00000683472 ENSG00000144134 HEK293_OSMI2_2hA HEK293_TMG_2hB RABL2A protein_coding protein_coding 12.35614 13.44851 10.48245 0.5616019 0.1796491 -0.3591665 0.6751740 2.4977508 0.0000000 0.51042322 0.00000000 -7.9702502 0.05059167 0.18340000 0.00000000 -0.183400000 5.173949e-17 5.173949e-17 FALSE TRUE
MSTRG.19100.16 ENSG00000144134 HEK293_OSMI2_2hA HEK293_TMG_2hB RABL2A protein_coding   12.35614 13.44851 10.48245 0.5616019 0.1796491 -0.3591665 0.6641127 0.6306385 0.7612420 0.10191562 0.13537243 0.2676731 0.05411250 0.04763333 0.07310000 0.025466667 5.263903e-01 5.173949e-17   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000144134 E001 0.1515154 0.0421993763 2.689905e-01   2 113627229 113627239 11 + 0.157 0.000 -10.344
ENSG00000144134 E002 0.3729606 0.0278579840 6.562360e-01 7.659113e-01 2 113627240 113627243 4 + 0.157 0.095 -0.845
ENSG00000144134 E003 3.2816950 0.0051869565 1.810216e-01 3.024890e-01 2 113627244 113627263 20 + 0.730 0.535 -0.847
ENSG00000144134 E004 5.7403228 0.0155023818 4.282796e-01 5.710807e-01 2 113627264 113627265 2 + 0.852 0.752 -0.396
ENSG00000144134 E005 7.6442246 0.0499244565 6.923858e-01 7.936495e-01 2 113627266 113627275 10 + 0.925 0.886 -0.150
ENSG00000144134 E006 9.8992038 0.0019489367 6.673681e-01 7.746367e-01 2 113627276 113627282 7 + 1.025 0.989 -0.136
ENSG00000144134 E007 11.5870450 0.0107142394 9.276132e-01 9.584648e-01 2 113627283 113627286 4 + 1.060 1.061 0.003
ENSG00000144134 E008 19.3588531 0.0088706585 4.038438e-01 5.476208e-01 2 113627287 113627306 20 + 1.315 1.251 -0.223
ENSG00000144134 E009 19.5039241 0.0039300588 5.179155e-01 6.522346e-01 2 113627307 113627310 4 + 1.305 1.262 -0.154
ENSG00000144134 E010 20.8721629 0.0012757188 6.130591e-01 7.318580e-01 2 113627311 113627386 76 + 1.324 1.294 -0.103
ENSG00000144134 E011 9.5547204 0.0018714973 6.360201e-01 7.501547e-01 2 113627387 113627400 14 + 0.947 1.010 0.231
ENSG00000144134 E012 2.1651660 0.0764066186 3.237737e-02 7.658533e-02 2 113627856 113628010 155 + 0.692 0.298 -1.991
ENSG00000144134 E013 4.9715890 0.0034568156 4.536405e-02 1.008624e-01 2 113628328 113628549 222 + 0.902 0.643 -1.039
ENSG00000144134 E014 5.3767357 0.0030862112 2.675853e-01 4.059063e-01 2 113628550 113628553 4 + 0.652 0.818 0.677
ENSG00000144134 E015 14.3362796 0.0134774014 3.459068e-01 4.900367e-01 2 113628554 113628569 16 + 1.060 1.176 0.416
ENSG00000144134 E016 17.6990521 0.0056813372 4.792426e-01 6.176306e-01 2 113628570 113628585 16 + 1.175 1.251 0.270
ENSG00000144134 E017 38.1528820 0.0011968910 9.706216e-02 1.859867e-01 2 113628586 113628713 128 + 1.610 1.523 -0.297
ENSG00000144134 E018 22.5832027 0.0008936914 1.051968e-02 3.002293e-02 2 113632915 113632944 30 + 1.448 1.272 -0.611
ENSG00000144134 E019 14.0761863 0.0303310174 1.398369e-01 2.478012e-01 2 113632945 113633475 531 + 1.256 1.091 -0.587
ENSG00000144134 E020 5.7860932 0.0351822940 2.870636e-01 4.275285e-01 2 113633476 113633895 420 + 0.902 0.749 -0.598
ENSG00000144134 E021 13.9566881 0.0013231755 1.965961e-01 3.219840e-01 2 113633919 113634152 234 + 1.043 1.178 0.488
ENSG00000144134 E022 17.7620810 0.0010970379 2.745059e-01 4.136683e-01 2 113634153 113634156 4 + 1.286 1.206 -0.284
ENSG00000144134 E023 47.1084468 0.0010840632 8.248722e-01 8.896640e-01 2 113634157 113634232 76 + 1.632 1.655 0.077
ENSG00000144134 E024 20.1354906 0.0259378646 4.762228e-01 6.148723e-01 2 113634233 113634620 388 + 1.235 1.328 0.329
ENSG00000144134 E025 2.4024171 0.0088963071 1.008200e-01 1.917117e-01 2 113635028 113635050 23 + 0.652 0.391 -1.259
ENSG00000144134 E026 32.9149389 0.0008929790 8.275036e-02 1.638548e-01 2 113635051 113635130 80 + 1.555 1.458 -0.335
ENSG00000144134 E027 7.5797124 0.0940454813 1.775439e-02 4.660893e-02 2 113635131 113635513 383 + 1.135 0.744 -1.478
ENSG00000144134 E028 4.0189832 0.0040657794 1.935373e-01 3.182289e-01 2 113637299 113637366 68 + 0.795 0.618 -0.733
ENSG00000144134 E029 5.5441392 0.0043786017 9.396430e-03 2.727200e-02 2 113637367 113637486 120 + 0.988 0.666 -1.264
ENSG00000144134 E030 5.6996425 0.0044371051 3.506499e-03 1.174477e-02 2 113637487 113637747 261 + 1.007 0.643 -1.431
ENSG00000144134 E031 4.5423122 0.0776059210 6.389836e-01 7.524882e-01 2 113640020 113640407 388 + 0.763 0.705 -0.239
ENSG00000144134 E032 6.7629494 0.0031006942 4.093292e-01 5.529416e-01 2 113640408 113640893 486 + 0.925 0.834 -0.350
ENSG00000144134 E033 24.1724255 0.0064346148 3.620338e-01 5.064367e-01 2 113640894 113641005 112 + 1.305 1.391 0.298
ENSG00000144134 E034 12.8761588 0.0014768664 2.502686e-01 3.862505e-01 2 113641006 113641352 347 + 1.175 1.076 -0.355
ENSG00000144134 E035 16.9469093 0.0012156671 9.774665e-01 9.899872e-01 2 113641353 113641355 3 + 1.223 1.231 0.027
ENSG00000144134 E036 26.4849423 0.0008042147 6.443115e-01 7.566378e-01 2 113641356 113641450 95 + 1.420 1.398 -0.075
ENSG00000144134 E037 3.9699524 0.0728514240 3.260601e-01 4.694995e-01 2 113641451 113641480 30 + 0.763 0.599 -0.689
ENSG00000144134 E038 15.2425787 0.0013528775 5.573657e-01 6.857866e-01 2 113641781 113641864 84 + 1.200 1.157 -0.152
ENSG00000144134 E039 24.5877612 0.0035024169 1.742286e-01 2.936835e-01 2 113642031 113642145 115 + 1.427 1.336 -0.315
ENSG00000144134 E040 224.1512980 0.0042902409 2.394756e-03 8.444002e-03 2 113642146 113643189 1044 + 2.241 2.352 0.371
ENSG00000144134 E041 44.3612594 0.0007103758 1.189063e-11 2.444541e-10 2 113643190 113643396 207 + 1.276 1.722 1.530