ENSG00000144048

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000272444 ENSG00000144048 HEK293_OSMI2_2hA HEK293_TMG_2hB DUSP11 protein_coding protein_coding 18.48135 10.43711 29.73295 1.903083 1.348554 1.509444 10.428725 9.279128 15.28049 2.020760 0.9830589 0.7190195 0.64840 0.88043333 0.5134000 -0.3670333 3.413155e-05 3.413155e-05 FALSE TRUE
MSTRG.18670.1 ENSG00000144048 HEK293_OSMI2_2hA HEK293_TMG_2hB DUSP11 protein_coding   18.48135 10.43711 29.73295 1.903083 1.348554 1.509444 7.133564 0.481217 13.43966 0.481217 0.6490144 4.7750657 0.29065 0.05283333 0.4523333 0.3995000 3.648288e-02 3.413155e-05 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000144048 E001 2.5078490 0.0094134912 5.719940e-01 6.981802e-01 2 73740081 73740118 38 - 0.487 0.577 0.423
ENSG00000144048 E002 0.1482932 0.0411597534 2.393423e-01   2 73761782 73761913 132 - 0.000 0.164 12.005
ENSG00000144048 E003 1.1801917 0.0117723026 4.157470e-02 9.395222e-02 2 73761914 73762212 299 - 0.164 0.519 2.327
ENSG00000144048 E004 4.5692749 0.0057695599 8.379133e-09 1.047444e-07 2 73762213 73762226 14 - 0.228 1.065 3.944
ENSG00000144048 E005 12.0169976 0.0015274749 2.525112e-11 4.926114e-10 2 73762227 73762259 33 - 0.748 1.397 2.383
ENSG00000144048 E006 66.0406118 0.0004357859 5.574911e-22 4.433880e-20 2 73762260 73762414 155 - 1.624 2.034 1.384
ENSG00000144048 E007 44.8524770 0.0007241078 4.890379e-07 4.331941e-06 2 73762415 73762430 16 - 1.544 1.803 0.881
ENSG00000144048 E008 104.9590549 0.0055645751 5.246793e-03 1.660274e-02 2 73762431 73762593 163 - 1.964 2.098 0.447
ENSG00000144048 E009 55.9924752 0.0004628155 1.877406e-01 3.108885e-01 2 73762594 73762605 12 - 1.727 1.788 0.205
ENSG00000144048 E010 193.2985180 0.0025795430 3.915506e-01 5.354659e-01 2 73762606 73762848 243 - 2.270 2.299 0.095
ENSG00000144048 E011 78.8723985 0.0004229400 3.436308e-01 4.876902e-01 2 73762849 73762859 11 - 1.883 1.919 0.122
ENSG00000144048 E012 1.9187286 0.0079754022 5.479407e-01 6.778966e-01 2 73766232 73766301 70 - 0.487 0.377 -0.578
ENSG00000144048 E013 187.9793330 0.0015720492 5.612992e-01 6.891614e-01 2 73766418 73766594 177 - 2.275 2.251 -0.082
ENSG00000144048 E014 0.1472490 0.0442317740 1.000000e+00   2 73766595 73766624 30 - 0.090 0.000 -10.272
ENSG00000144048 E015 89.2413496 0.0045735949 4.540036e-02 1.009277e-01 2 73766828 73766867 40 - 1.984 1.871 -0.380
ENSG00000144048 E016 92.0869681 0.0003010740 3.055077e-02 7.304999e-02 2 73766868 73766903 36 - 1.990 1.905 -0.286
ENSG00000144048 E017 0.1451727 0.0431444180 1.000000e+00   2 73766904 73766919 16 - 0.090 0.000 -10.272
ENSG00000144048 E018 85.4986691 0.0003793937 5.791495e-01 7.041067e-01 2 73767161 73767207 47 - 1.937 1.912 -0.083
ENSG00000144048 E019 8.8593722 0.0232415534 9.272308e-02 1.793784e-01 2 73767419 73768952 1534 - 0.897 1.097 0.739
ENSG00000144048 E020 89.9580140 0.0004400959 6.483463e-01 7.598627e-01 2 73769265 73769325 61 - 1.946 1.960 0.049
ENSG00000144048 E021 0.5117019 0.0810780482 2.297697e-02 5.770040e-02 2 73773253 73773497 245 - 0.000 0.377 13.590
ENSG00000144048 E022 0.6589510 0.0588901883 9.689251e-02 1.857405e-01 2 73773498 73773799 302 - 0.090 0.377 2.588
ENSG00000144048 E023 127.7559685 0.0002840947 3.941207e-03 1.297709e-02 2 73773800 73773923 124 - 2.134 2.037 -0.324
ENSG00000144048 E024 123.5128440 0.0003124562 3.144620e-05 1.861626e-04 2 73774913 73775044 132 - 2.134 1.992 -0.477
ENSG00000144048 E025 120.4954814 0.0011015985 2.936503e-05 1.751280e-04 2 73778301 73778376 76 - 2.128 1.973 -0.520
ENSG00000144048 E026 0.0000000       2 73779471 73779582 112 -      
ENSG00000144048 E027 0.2214452 0.0528813784 2.356349e-01   2 73779871 73779873 3 - 0.000 0.165 12.014
ENSG00000144048 E028 143.3815654 0.0103015464 3.534897e-03 1.182608e-02 2 73779874 73780132 259 - 2.204 2.031 -0.578