ENSG00000143995

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000272369 ENSG00000143995 HEK293_OSMI2_2hA HEK293_TMG_2hB MEIS1 protein_coding protein_coding 2.160184 1.49044 1.828644 0.1678362 0.03685668 0.2932569 1.31188343 1.05046091 1.3000438 0.05892939 0.10678181 0.3049236 0.64067500 0.71330000 0.70916667 -0.004133333 1.0000000 0.0334029 FALSE TRUE
ENST00000398506 ENSG00000143995 HEK293_OSMI2_2hA HEK293_TMG_2hB MEIS1 protein_coding protein_coding 2.160184 1.49044 1.828644 0.1678362 0.03685668 0.2932569 0.09151882 0.18113876 0.1048875 0.11315392 0.03688885 -0.7343989 0.05215417 0.11060000 0.05796667 -0.052633333 0.8048366 0.0334029 FALSE TRUE
ENST00000488550 ENSG00000143995 HEK293_OSMI2_2hA HEK293_TMG_2hB MEIS1 protein_coding protein_coding 2.160184 1.49044 1.828644 0.1678362 0.03685668 0.2932569 0.27437242 0.09216526 0.3577827 0.01367737 0.05035949 1.8479490 0.12709167 0.06440000 0.19670000 0.132300000 0.0334029 0.0334029 FALSE TRUE
ENST00000542964 ENSG00000143995 HEK293_OSMI2_2hA HEK293_TMG_2hB MEIS1 protein_coding processed_transcript 2.160184 1.49044 1.828644 0.1678362 0.03685668 0.2932569 0.03948760 0.08243998 0.0000000 0.08243998 0.00000000 -3.2085170 0.01832917 0.06126667 0.00000000 -0.061266667 0.7419278 0.0334029 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000143995 E001 0.0000000       2 66433452 66433567 116 +      
ENSG00000143995 E002 1.3254792 0.0114673391 5.918446e-01 7.145154e-01 2 66435125 66435132 8 + 0.404 0.308 -0.571
ENSG00000143995 E003 2.7282646 0.0057132882 1.412864e-01 2.498043e-01 2 66435133 66435168 36 + 0.671 0.435 -1.098
ENSG00000143995 E004 18.8400218 0.0010870208 4.823922e-02 1.060587e-01 2 66435169 66435557 389 + 1.376 1.226 -0.523
ENSG00000143995 E005 13.4569684 0.0027676978 9.848799e-01 9.946028e-01 2 66435558 66435833 276 + 1.162 1.159 -0.010
ENSG00000143995 E006 6.1287802 0.0042783463 6.496348e-01 7.608505e-01 2 66435834 66435868 35 + 0.890 0.836 -0.210
ENSG00000143995 E007 0.3299976 0.0274424043 1.703119e-01   2 66436896 66436916 21 + 0.000 0.227 11.888
ENSG00000143995 E008 0.3299976 0.0274424043 1.703119e-01   2 66436917 66436943 27 + 0.000 0.227 11.888
ENSG00000143995 E009 0.0000000       2 66437393 66437736 344 +      
ENSG00000143995 E010 13.4671139 0.0016653603 3.137512e-01 4.563858e-01 2 66437737 66437963 227 + 1.214 1.127 -0.311
ENSG00000143995 E011 0.3299976 0.0274424043 1.703119e-01   2 66439321 66439671 351 + 0.000 0.227 11.888
ENSG00000143995 E012 13.1844817 0.0014261717 7.067473e-01 8.048569e-01 2 66439843 66439984 142 + 1.171 1.138 -0.119
ENSG00000143995 E013 0.0000000       2 66440097 66440345 249 +      
ENSG00000143995 E014 10.1635012 0.0020519876 1.806779e-01 3.020391e-01 2 66440562 66440612 51 + 0.968 1.104 0.497
ENSG00000143995 E015 0.0000000       2 66440678 66440706 29 +      
ENSG00000143995 E016 0.0000000       2 66440707 66440730 24 +      
ENSG00000143995 E017 0.0000000       2 66440731 66441007 277 +      
ENSG00000143995 E018 9.4494735 0.0019121334 5.373415e-01 6.689238e-01 2 66441414 66441464 51 + 1.047 0.983 -0.236
ENSG00000143995 E019 0.1482932 0.0411597534 4.347621e-01   2 66442775 66442901 127 + 0.000 0.128 10.879
ENSG00000143995 E020 10.9585485 0.0016474165 2.234531e-01 3.545110e-01 2 66442902 66442964 63 + 1.143 1.027 -0.422
ENSG00000143995 E021 13.6142837 0.0015005478 6.151985e-01 7.335246e-01 2 66442965 66443048 84 + 1.153 1.198 0.162
ENSG00000143995 E022 0.0000000       2 66443049 66443772 724 +      
ENSG00000143995 E023 0.0000000       2 66445193 66445296 104 +      
ENSG00000143995 E024 0.0000000       2 66454709 66454794 86 +      
ENSG00000143995 E025 0.1472490 0.0427307290 5.563297e-01   2 66461798 66461887 90 + 0.116 0.000 -11.620
ENSG00000143995 E026 17.6192606 0.0012031437 9.195186e-01 9.531629e-01 2 66464109 66464220 112 + 1.268 1.277 0.031
ENSG00000143995 E027 0.0000000       2 66496026 66496200 175 +      
ENSG00000143995 E028 0.0000000       2 66508927 66509123 197 +      
ENSG00000143995 E029 20.9978918 0.0008860036 4.115423e-01 5.550961e-01 2 66512149 66512294 146 + 1.315 1.375 0.208
ENSG00000143995 E030 19.3370304 0.0009957680 4.812657e-01 6.195045e-01 2 66547943 66548019 77 + 1.289 1.342 0.187
ENSG00000143995 E031 0.0000000       2 66562082 66562119 38 +      
ENSG00000143995 E032 20.1018675 0.0010750562 6.601052e-01 7.688119e-01 2 66567453 66567511 59 + 1.315 1.349 0.117
ENSG00000143995 E033 0.8952612 0.0150197585 1.199722e-01 2.199420e-01 2 66567512 66568536 1025 + 0.404 0.128 -2.159
ENSG00000143995 E034 21.4147511 0.0008985340 6.897770e-01 7.915966e-01 2 66568667 66568756 90 + 1.370 1.342 -0.096
ENSG00000143995 E035 3.1303595 0.0052990868 2.634248e-03 9.173046e-03 2 66568757 66569049 293 + 0.794 0.308 -2.337
ENSG00000143995 E036 13.5008263 0.0014229887 2.174919e-01 3.473592e-01 2 66569050 66569145 96 + 1.214 1.104 -0.392
ENSG00000143995 E037 14.3898040 0.0066451138 1.720368e-06 1.357372e-05 2 66569146 66571245 2100 + 1.370 0.897 -1.703
ENSG00000143995 E038 99.6253970 0.0004929899 1.119708e-05 7.354991e-05 2 66571246 66573869 2624 + 1.932 2.067 0.451