ENSG00000143971

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000272342 ENSG00000143971 HEK293_OSMI2_2hA HEK293_TMG_2hB ETAA1 protein_coding protein_coding 3.837645 1.154372 6.318109 0.1521102 0.1343739 2.442222 3.3851508 0.8933071 5.6353360 0.2121948 0.06027860 2.6437710 0.86882500 0.7582333 0.8924667 0.1342333 0.33155075 0.04475153 FALSE TRUE
ENST00000644028 ENSG00000143971 HEK293_OSMI2_2hA HEK293_TMG_2hB ETAA1 protein_coding protein_coding 3.837645 1.154372 6.318109 0.1521102 0.1343739 2.442222 0.1916592 0.1856092 0.2870292 0.0533872 0.05846043 0.6026309 0.06005417 0.1722667 0.0452000 -0.1270667 0.04475153 0.04475153 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000143971 E001 0.0000000       2 67397316 67397321 6 +      
ENSG00000143971 E002 0.0000000       2 67397322 67397323 2 +      
ENSG00000143971 E003 0.8868421 0.0520313385 1.000000e+00 1.000000e+00 2 67397324 67397330 7 + 0.239 0.235 -0.030
ENSG00000143971 E004 2.4473839 0.0267025504 1.793652e-01 3.003217e-01 2 67397331 67397332 2 + 0.418 0.662 1.152
ENSG00000143971 E005 3.1932060 0.0514463366 2.446890e-01 3.796776e-01 2 67397333 67397335 3 + 0.506 0.723 0.957
ENSG00000143971 E006 3.3447214 0.0766466610 3.227568e-01 4.660820e-01 2 67397336 67397337 2 + 0.526 0.721 0.857
ENSG00000143971 E007 5.8378006 0.0045562721 8.072070e-01 8.775461e-01 2 67397338 67397344 7 + 0.767 0.726 -0.165
ENSG00000143971 E008 11.8635320 0.0204810399 4.887721e-01 6.262946e-01 2 67397345 67397354 10 + 1.004 1.096 0.333
ENSG00000143971 E009 37.5278722 0.0033168418 6.131314e-01 7.319212e-01 2 67397355 67397671 317 + 1.480 1.516 0.121
ENSG00000143971 E010 3.1085009 0.0055809871 7.117775e-01 8.086700e-01 2 67399083 67399168 86 + 0.525 0.589 0.296
ENSG00000143971 E011 15.7658168 0.0132408794 1.102831e-01 2.059642e-01 2 67399169 67399172 4 + 1.162 0.953 -0.761
ENSG00000143971 E012 34.7494319 0.0072147646 1.322037e-01 2.371743e-01 2 67399173 67399297 125 + 1.478 1.342 -0.471
ENSG00000143971 E013 30.0045263 0.0007273022 8.765177e-01 9.247497e-01 2 67399550 67399626 77 + 1.397 1.382 -0.053
ENSG00000143971 E014 7.5360086 0.0367751363 1.187865e-02 3.324090e-02 2 67400344 67402807 2464 + 0.906 0.389 -2.287
ENSG00000143971 E015 1.7682599 0.0085949476 3.969013e-01 5.406696e-01 2 67402808 67402861 54 + 0.417 0.236 -1.163
ENSG00000143971 E016 39.8965564 0.0008116798 3.147735e-01 4.575180e-01 2 67402862 67402974 113 + 1.528 1.453 -0.257
ENSG00000143971 E017 32.5408633 0.0006392811 6.442635e-03 1.977252e-02 2 67403225 67403367 143 + 1.463 1.227 -0.822
ENSG00000143971 E018 67.1999218 0.0030983975 2.101026e-03 7.537142e-03 2 67403368 67403844 477 + 1.764 1.570 -0.658
ENSG00000143971 E019 71.7453230 0.0792302874 1.295349e-01 2.335133e-01 2 67403845 67404262 418 + 1.787 1.645 -0.482
ENSG00000143971 E020 114.6855731 0.0029602683 3.527215e-02 8.217019e-02 2 67404263 67404996 734 + 1.979 1.879 -0.337
ENSG00000143971 E021 57.4692409 0.0004936275 2.844373e-01 4.246721e-01 2 67404997 67405235 239 + 1.655 1.712 0.192
ENSG00000143971 E022 50.7345261 0.0005008168 1.254694e-06 1.020426e-05 2 67405236 67405335 100 + 1.549 1.809 0.885
ENSG00000143971 E023 81.8979221 0.0088023232 1.637157e-06 1.297826e-05 2 67409911 67412089 2179 + 1.753 2.023 0.909