ENSG00000143924

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000318522 ENSG00000143924 HEK293_OSMI2_2hA HEK293_TMG_2hB EML4 protein_coding protein_coding 17.6211 8.862011 26.33581 0.06079049 0.5258274 1.570241 12.955541 5.7018911 19.781776 1.4884892 1.0052773 1.7928607 0.70956667 0.644833333 0.7518667 0.10703333 9.647347e-01 5.932068e-09 FALSE TRUE
ENST00000402711 ENSG00000143924 HEK293_OSMI2_2hA HEK293_TMG_2hB EML4 protein_coding protein_coding 17.6211 8.862011 26.33581 0.06079049 0.5258274 1.570241 1.008992 0.0114126 1.881311 0.0114126 0.2515281 6.4647829 0.03838333 0.001266667 0.0715000 0.07023333 5.932068e-09 5.932068e-09 FALSE TRUE
ENST00000406175 ENSG00000143924 HEK293_OSMI2_2hA HEK293_TMG_2hB EML4 protein_coding retained_intron 17.6211 8.862011 26.33581 0.06079049 0.5258274 1.570241 2.091175 3.0537135 1.571174 1.5276991 0.1126949 -0.9542854 0.18296667 0.343100000 0.0596000 -0.28350000 6.554771e-01 5.932068e-09 FALSE TRUE
MSTRG.18276.3 ENSG00000143924 HEK293_OSMI2_2hA HEK293_TMG_2hB EML4 protein_coding   17.6211 8.862011 26.33581 0.06079049 0.5258274 1.570241 0.878250 0.0000000 1.648465 0.0000000 0.8846255 7.3737048 0.03423333 0.000000000 0.0621000 0.06210000 3.094375e-01 5.932068e-09 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000143924 E001 13.2994432 0.0032846608 6.048899e-04 2.551477e-03 2 42169353 42169380 28 + 1.168 0.812 -1.324
ENSG00000143924 E002 21.7910964 0.0131625890 5.963665e-03 1.851127e-02 2 42169381 42169390 10 + 1.350 1.121 -0.808
ENSG00000143924 E003 42.2674564 0.0075982335 3.428082e-03 1.151877e-02 2 42169391 42169460 70 + 1.614 1.454 -0.547
ENSG00000143924 E004 86.4003689 0.0177755113 4.198270e-04 1.850296e-03 2 42169461 42169636 176 + 1.929 1.717 -0.715
ENSG00000143924 E005 2.5078410 0.0061377776 3.422136e-03 1.150328e-02 2 42207929 42208082 154 + 0.597 0.000 -12.665
ENSG00000143924 E006 110.4656077 0.0232628770 3.819286e-04 1.704963e-03 2 42245505 42245687 183 + 2.036 1.810 -0.761
ENSG00000143924 E007 0.0000000       2 42245688 42245688 1 +      
ENSG00000143924 E008 115.0185107 0.0090915834 4.028351e-05 2.320126e-04 2 42256501 42256630 130 + 2.046 1.864 -0.611
ENSG00000143924 E009 113.0796137 0.0162926407 1.462108e-02 3.964165e-02 2 42261121 42261294 174 + 2.025 1.918 -0.359
ENSG00000143924 E010 0.4355181 0.6036708555 7.313728e-01 8.230444e-01 2 42261295 42261513 219 + 0.181 0.000 -10.154
ENSG00000143924 E011 114.5201911 0.0177851707 4.227830e-03 1.377954e-02 2 42263178 42263306 129 + 2.037 1.894 -0.482
ENSG00000143924 E012 50.6378257 0.0296587531 1.795087e-02 4.702867e-02 2 42264706 42264731 26 + 1.694 1.523 -0.581
ENSG00000143924 E013 1.0330470 0.0118479382 8.946128e-02 1.743119e-01 2 42264919 42264951 33 + 0.346 0.000 -11.385
ENSG00000143924 E014 90.6470333 0.0003105478 3.598293e-08 3.988800e-07 2 42280850 42280973 124 + 1.944 1.761 -0.617
ENSG00000143924 E015 84.0157579 0.0027386439 1.275726e-04 6.480986e-04 2 42282823 42282908 86 + 1.900 1.766 -0.450
ENSG00000143924 E016 84.2224043 0.0003876391 1.729989e-04 8.481917e-04 2 42282909 42282972 64 + 1.896 1.792 -0.351
ENSG00000143924 E017 84.1362550 0.0006064940 1.248213e-04 6.358948e-04 2 42284634 42284703 70 + 1.898 1.788 -0.372
ENSG00000143924 E018 9.3681787 0.0029197636 7.473293e-03 2.244547e-02 2 42285923 42286268 346 + 1.024 0.721 -1.164
ENSG00000143924 E019 114.8775590 0.0003234590 7.652600e-05 4.116187e-04 2 42286269 42286379 111 + 2.025 1.939 -0.289
ENSG00000143924 E020 110.2356098 0.0002612395 9.980014e-03 2.871459e-02 2 42288227 42288322 96 + 1.994 1.963 -0.105
ENSG00000143924 E021 0.2998086 0.0290462916 4.255261e-01   2 42288323 42289913 1591 + 0.070 0.206 1.807
ENSG00000143924 E022 134.8340741 0.0003790635 2.574790e-03 8.988634e-03 2 42295125 42295259 135 + 2.085 2.046 -0.129
ENSG00000143924 E023 155.2510451 0.0065121183 2.584551e-02 6.362042e-02 2 42295381 42295516 136 + 2.144 2.103 -0.136
ENSG00000143924 E024 164.9547961 0.0002196084 9.642464e-04 3.836280e-03 2 42301241 42301392 152 + 2.169 2.133 -0.122
ENSG00000143924 E025 137.0991060 0.0002518761 5.492996e-02 1.178759e-01 2 42303104 42303229 126 + 2.080 2.083 0.010
ENSG00000143924 E026 132.1558544 0.0002456794 7.654305e-02 1.539630e-01 2 42303315 42303446 132 + 2.063 2.070 0.023
ENSG00000143924 E027 102.6042582 0.0003076654 2.138376e-01 3.430568e-01 2 42304484 42304551 68 + 1.949 1.969 0.066
ENSG00000143924 E028 105.6622628 0.0013823024 9.599590e-01 9.788456e-01 2 42315962 42316050 89 + 1.947 2.018 0.239
ENSG00000143924 E029 80.8104664 0.0003015189 3.358823e-01 4.797065e-01 2 42317427 42317473 47 + 1.847 1.873 0.088
ENSG00000143924 E030 82.3874000 0.0003179291 1.625433e-02 4.328433e-02 2 42317474 42317524 51 + 1.872 1.833 -0.133
ENSG00000143924 E031 1.5123819 0.0108181749 3.107842e-01 4.532113e-01 2 42319535 42319998 464 + 0.310 0.536 1.222
ENSG00000143924 E032 108.9007348 0.0025770001 1.078710e-01 2.023810e-01 2 42325467 42325554 88 + 1.982 1.978 -0.014
ENSG00000143924 E033 116.1356646 0.0039379738 3.526747e-01 4.969211e-01 2 42326154 42326252 99 + 2.003 2.028 0.084
ENSG00000143924 E034 114.2742388 0.0002788354 9.463223e-01 9.703129e-01 2 42328886 42329016 131 + 1.987 2.053 0.224
ENSG00000143924 E035 329.7424188 0.0001647033 5.540924e-01 6.831262e-01 2 42329734 42330268 535 + 2.438 2.521 0.275
ENSG00000143924 E036 561.0625441 0.0034920699 4.756460e-09 6.232515e-08 2 42330269 42331591 1323 + 2.615 2.856 0.802
ENSG00000143924 E037 473.9627964 0.0223083281 1.853108e-09 2.612485e-08 2 42331592 42332589 998 + 2.438 2.916 1.593