ENSG00000143919

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000378494 ENSG00000143919 HEK293_OSMI2_2hA HEK293_TMG_2hB CAMKMT protein_coding protein_coding 10.02138 11.14106 9.580175 0.9436173 0.5911151 -0.2175518 8.6165504 10.07133463 7.2556324 0.54696465 0.4106685 -0.4725264 0.8615292 0.908833333 0.75823333 -0.15060000 2.308583e-02 8.994104e-06 FALSE TRUE
ENST00000402247 ENSG00000143919 HEK293_OSMI2_2hA HEK293_TMG_2hB CAMKMT protein_coding protein_coding 10.02138 11.14106 9.580175 0.9436173 0.5911151 -0.2175518 0.1933774 0.03216588 0.6184336 0.03216588 0.1551716 3.8976125 0.0197750 0.002833333 0.06326667 0.06043333 8.994104e-06 8.994104e-06 FALSE TRUE
ENST00000428929 ENSG00000143919 HEK293_OSMI2_2hA HEK293_TMG_2hB CAMKMT protein_coding protein_coding 10.02138 11.14106 9.580175 0.9436173 0.5911151 -0.2175518 0.4956637 0.47727969 1.1183438 0.31600647 0.1519895 1.2113847 0.0497125 0.038766667 0.11803333 0.07926667 2.837261e-01 8.994104e-06   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000143919 E001 3.4340526 0.0186758486 6.941119e-01 7.950075e-01 2 44361947 44361949 3 + 0.611 0.683 0.311
ENSG00000143919 E002 4.3219243 0.0049324086 6.630194e-01 7.711820e-01 2 44361950 44361955 6 + 0.686 0.754 0.279
ENSG00000143919 E003 7.1618722 0.0023268051 7.200331e-01 8.147124e-01 2 44361956 44361963 8 + 0.878 0.925 0.182
ENSG00000143919 E004 38.9677518 0.0005556877 2.481015e-03 8.707156e-03 2 44361964 44362104 141 + 1.684 1.525 -0.544
ENSG00000143919 E005 33.3647549 0.0007493990 2.755715e-02 6.712637e-02 2 44362105 44362145 41 + 1.601 1.475 -0.428
ENSG00000143919 E006 0.6611159 0.0482577970 1.890528e-01 3.125533e-01 2 44369711 44370007 297 + 0.333 0.106 -2.063
ENSG00000143919 E007 33.6618483 0.0006362204 2.109672e-02 5.380238e-02 2 44372716 44372741 26 + 1.609 1.479 -0.443
ENSG00000143919 E008 29.5286850 0.0006827969 6.645332e-02 1.374792e-01 2 44372742 44372747 6 + 1.542 1.433 -0.374
ENSG00000143919 E009 40.5927318 0.0005351606 4.586798e-02 1.017941e-01 2 44372748 44372794 47 + 1.670 1.569 -0.346
ENSG00000143919 E010 68.7205702 0.0004969831 5.222049e-01 6.560485e-01 2 44372795 44372888 94 + 1.844 1.823 -0.074
ENSG00000143919 E011 72.5822419 0.0004427437 9.657168e-02 1.852192e-01 2 44390241 44390305 65 + 1.892 1.830 -0.210
ENSG00000143919 E012 3.9146126 0.0171921932 4.664268e-02 1.031930e-01 2 44391885 44392017 133 + 0.855 0.572 -1.173
ENSG00000143919 E013 1.0675023 0.0121989077 1.657850e-02 4.401272e-02 2 44392018 44392073 56 + 0.520 0.106 -3.069
ENSG00000143919 E014 0.1515154 0.0428863240 3.576503e-01   2 44393337 44393528 192 + 0.141 0.000 -12.643
ENSG00000143919 E015 0.1451727 0.0431709416 3.579520e-01   2 44400773 44400885 113 + 0.141 0.000 -12.642
ENSG00000143919 E016 0.1472490 0.0463262591 3.569563e-01   2 44401020 44401145 126 + 0.141 0.000 -12.637
ENSG00000143919 E017 11.4359153 0.0015327326 3.350995e-01 4.788613e-01 2 44456568 44457261 694 + 1.137 1.048 -0.319
ENSG00000143919 E018 3.1367142 0.0048705335 2.635125e-03 9.175424e-03 2 44549555 44549728 174 + 0.831 0.376 -2.069
ENSG00000143919 E019 0.4460135 0.0505250680 4.651984e-02 1.029781e-01 2 44549729 44549785 57 + 0.333 0.000 -14.178
ENSG00000143919 E020 0.1482932 0.0406263526 6.563016e-01   2 44550645 44550790 146 + 0.000 0.105 11.169
ENSG00000143919 E021 0.0000000       2 44631491 44631714 224 +      
ENSG00000143919 E022 0.1451727 0.0431709416 3.579520e-01   2 44676594 44676775 182 + 0.141 0.000 -12.642
ENSG00000143919 E023 40.9494123 0.0013164845 9.426026e-01 9.679662e-01 2 44704283 44704284 2 + 1.605 1.614 0.032
ENSG00000143919 E024 62.2843650 0.0040837281 6.561947e-01 7.658771e-01 2 44704285 44704343 59 + 1.772 1.800 0.097
ENSG00000143919 E025 57.1818984 0.0004576772 3.136704e-01 4.562839e-01 2 44706287 44706341 55 + 1.724 1.777 0.179
ENSG00000143919 E026 56.1161620 0.0004842779 3.151277e-01 4.578855e-01 2 44707399 44707462 64 + 1.718 1.771 0.180
ENSG00000143919 E027 61.6976735 0.0005521614 3.208865e-01 4.640569e-01 2 44715287 44715353 67 + 1.760 1.811 0.172
ENSG00000143919 E028 0.3697384 0.0249566830 3.100209e-01 4.523890e-01 2 44723729 44723816 88 + 0.000 0.190 12.187
ENSG00000143919 E029 69.0676715 0.0018892261 8.363859e-01 8.976636e-01 2 44743622 44743696 75 + 1.830 1.847 0.056
ENSG00000143919 E030 58.5267082 0.0017612823 3.820693e-01 5.263180e-01 2 44754055 44754118 64 + 1.736 1.786 0.167
ENSG00000143919 E031 83.8231201 0.0003648539 3.707819e-01 5.151970e-01 2 44766430 44766561 132 + 1.892 1.932 0.134
ENSG00000143919 E032 142.3357027 0.0030984584 1.373789e-05 8.837357e-05 2 44772036 44772592 557 + 2.033 2.196 0.545