ENSG00000143842

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000367204 ENSG00000143842 HEK293_OSMI2_2hA HEK293_TMG_2hB SOX13 protein_coding protein_coding 6.187852 8.336302 4.307998 0.7347938 0.2302383 -0.9507745 1.8444992 1.9238296 2.0285622 0.5044095 0.35052524 0.07609133 0.30702500 0.22323333 0.46523333 0.24200000 0.03930266 0.03789968 FALSE TRUE
ENST00000525258 ENSG00000143842 HEK293_OSMI2_2hA HEK293_TMG_2hB SOX13 protein_coding retained_intron 6.187852 8.336302 4.307998 0.7347938 0.2302383 -0.9507745 0.4475477 0.2967699 0.4794438 0.1321736 0.12803087 0.67398635 0.07803750 0.03373333 0.11010000 0.07636667 0.10332722 0.03789968 FALSE FALSE
ENST00000618875 ENSG00000143842 HEK293_OSMI2_2hA HEK293_TMG_2hB SOX13 protein_coding protein_coding 6.187852 8.336302 4.307998 0.7347938 0.2302383 -0.9507745 2.9561007 4.7141361 1.2608472 0.5648965 0.05277821 -1.89425994 0.46006250 0.57576667 0.29523333 -0.28053333 0.03789968 0.03789968 FALSE TRUE
MSTRG.2885.5 ENSG00000143842 HEK293_OSMI2_2hA HEK293_TMG_2hB SOX13 protein_coding   6.187852 8.336302 4.307998 0.7347938 0.2302383 -0.9507745 0.5978524 0.9634299 0.3477434 0.4304436 0.15578884 -1.44415196 0.09742083 0.11543333 0.08406667 -0.03136667 0.84177519 0.03789968 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000143842 E001 10.0549526 0.0017581989 8.306635e-04 3.368583e-03 1 204073115 204073152 38 + 1.193 0.887 -1.123
ENSG00000143842 E002 9.8335074 0.0017985457 5.535044e-04 2.359687e-03 1 204073153 204073155 3 + 1.193 0.873 -1.176
ENSG00000143842 E003 19.4779183 0.0010272332 1.179358e-04 6.043928e-04 1 204073156 204073218 63 + 1.433 1.173 -0.911
ENSG00000143842 E004 39.5755005 0.0172425182 7.036917e-03 2.132110e-02 1 204073219 204073711 493 + 1.676 1.505 -0.583
ENSG00000143842 E005 0.5546650 0.0200072733 1.000000e+00 1.000000e+00 1 204074026 204074389 364 + 0.159 0.170 0.115
ENSG00000143842 E006 0.3299976 0.0274424043 4.698678e-01   1 204078129 204078185 57 + 0.000 0.170 10.404
ENSG00000143842 E007 7.4280492 0.0031699936 9.678217e-01 9.838956e-01 1 204112915 204112915 1 + 0.857 0.887 0.116
ENSG00000143842 E008 39.4815907 0.0121066398 1.427315e-01 2.517461e-01 1 204112916 204113134 219 + 1.606 1.544 -0.215
ENSG00000143842 E009 40.5933980 0.0006237474 3.967887e-04 1.762041e-03 1 204114321 204114432 112 + 1.680 1.523 -0.537
ENSG00000143842 E010 37.5016854 0.0006326852 3.789101e-03 1.255196e-02 1 204114519 204114605 87 + 1.629 1.500 -0.441
ENSG00000143842 E011 0.9244034 0.0130912936 5.245488e-01 6.580391e-01 1 204116065 204116349 285 + 0.159 0.292 1.115
ENSG00000143842 E012 0.4031496 0.0240903966 4.687474e-01 6.081217e-01 1 204116504 204116506 3 + 0.000 0.170 10.431
ENSG00000143842 E013 47.4795859 0.0007262367 2.299496e-01 3.623990e-01 1 204116507 204116679 173 + 1.664 1.640 -0.083
ENSG00000143842 E014 26.1915488 0.0008455418 5.468594e-01 6.769617e-01 1 204117122 204117190 69 + 1.338 1.421 0.287
ENSG00000143842 E015 8.1227808 0.0029684235 7.286499e-01 8.210605e-01 1 204117593 204117595 3 + 0.931 0.925 -0.020
ENSG00000143842 E016 26.6140148 0.0200662155 8.088154e-01 8.785938e-01 1 204117596 204117707 112 + 1.356 1.424 0.234
ENSG00000143842 E017 4.5306731 0.0048956644 6.939084e-02 1.423547e-01 1 204117708 204119859 2152 + 0.857 0.638 -0.888
ENSG00000143842 E018 0.1482932 0.0425549868 1.000000e+00   1 204121871 204121899 29 + 0.000 0.093 9.331
ENSG00000143842 E019 18.7551901 0.0010099708 8.924486e-01 9.352759e-01 1 204121900 204121985 86 + 1.217 1.267 0.175
ENSG00000143842 E020 25.7768650 0.0009984246 4.243502e-01 5.673282e-01 1 204122237 204122385 149 + 1.311 1.410 0.342
ENSG00000143842 E021 14.6900852 0.0076916526 5.932310e-01 7.156647e-01 1 204122386 204122399 14 + 1.081 1.176 0.338
ENSG00000143842 E022 4.6383954 0.0335189224 4.833117e-02 1.062142e-01 1 204122400 204122853 454 + 0.883 0.616 -1.085
ENSG00000143842 E023 36.3069678 0.0007168079 1.968130e-01 3.222557e-01 1 204122854 204122963 110 + 1.440 1.562 0.417
ENSG00000143842 E024 44.1083551 0.0008287367 2.858609e-01 4.262299e-01 1 204123112 204123208 97 + 1.625 1.605 -0.067
ENSG00000143842 E025 56.5395165 0.0004189725 2.240475e-01 3.552508e-01 1 204123661 204123804 144 + 1.733 1.714 -0.065
ENSG00000143842 E026 62.9962930 0.0059017575 6.413089e-01 7.543621e-01 1 204124641 204124857 217 + 1.722 1.791 0.232
ENSG00000143842 E027 380.5691281 0.0064053747 5.045412e-06 3.587846e-05 1 204125858 204127743 1886 + 2.414 2.595 0.604