ENSG00000143815

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000272163 ENSG00000143815 HEK293_OSMI2_2hA HEK293_TMG_2hB LBR protein_coding protein_coding 84.83092 31.89296 133.5976 9.633231 3.793967 2.06624 64.362987 31.20097017 99.412933 9.54479138 3.553046 1.671525 0.83393750 0.9760333333 0.74470000 -0.23133333 2.405240e-13 6.267629e-19 FALSE TRUE
ENST00000441022 ENSG00000143815 HEK293_OSMI2_2hA HEK293_TMG_2hB LBR protein_coding retained_intron 84.83092 31.89296 133.5976 9.633231 3.793967 2.06624 7.351737 0.00000000 9.973059 0.00000000 2.535944 9.963338 0.05280417 0.0000000000 0.07373333 0.07373333 4.464784e-14 6.267629e-19   FALSE
MSTRG.3138.5 ENSG00000143815 HEK293_OSMI2_2hA HEK293_TMG_2hB LBR protein_coding   84.83092 31.89296 133.5976 9.633231 3.793967 2.06624 4.167117 0.00000000 8.852948 0.00000000 1.495015 9.791643 0.03021667 0.0000000000 0.06590000 0.06590000 6.267629e-19 6.267629e-19 FALSE TRUE
MSTRG.3138.7 ENSG00000143815 HEK293_OSMI2_2hA HEK293_TMG_2hB LBR protein_coding   84.83092 31.89296 133.5976 9.633231 3.793967 2.06624 5.946228 0.01155026 10.168679 0.01155026 2.109958 8.883630 0.04066667 0.0005666667 0.07673333 0.07616667 8.034343e-14 6.267629e-19 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000143815 E001 0.7341808 0.0187171549 4.209995e-01 5.641592e-01 1 225401431 225401501 71 - 0.166 0.372 1.540
ENSG00000143815 E002 3.9058963 0.0044017600 2.330535e-12 5.384960e-11 1 225401502 225401502 1 - 0.118 1.202 5.583
ENSG00000143815 E003 17.3963352 0.0010836201 8.368058e-19 4.670900e-17 1 225401503 225401529 27 - 0.840 1.680 2.986
ENSG00000143815 E004 728.7057913 0.0017791577 3.872972e-116 1.746959e-112 1 225401530 225401728 199 - 2.535 3.198 2.205
ENSG00000143815 E005 2759.9608613 0.0028051811 1.000299e-46 5.107915e-44 1 225401729 225403089 1361 - 3.230 3.644 1.374
ENSG00000143815 E006 598.9268108 0.0003590331 4.274021e-08 4.675214e-07 1 225403090 225403203 114 - 2.695 2.712 0.056
ENSG00000143815 E007 869.8718118 0.0002140746 1.062411e-14 3.479782e-13 1 225403204 225403463 260 - 2.860 2.863 0.011
ENSG00000143815 E008 545.2901804 0.0001387003 3.683463e-08 4.074629e-07 1 225404404 225404526 123 - 2.653 2.676 0.077
ENSG00000143815 E009 0.7019140 0.0248846590 2.440720e-01 3.789872e-01 1 225404527 225404565 39 - 0.118 0.374 2.131
ENSG00000143815 E010 466.5289304 0.0001535711 5.636378e-09 7.288205e-08 1 225404626 225404706 81 - 2.589 2.596 0.023
ENSG00000143815 E011 6.0130721 0.0058693948 7.360469e-01 8.266602e-01 1 225406562 225406663 102 - 0.741 0.892 0.591
ENSG00000143815 E012 674.7154727 0.0001670073 2.898302e-17 1.332382e-15 1 225406664 225406832 169 - 2.755 2.732 -0.076
ENSG00000143815 E013 619.2566553 0.0001229530 1.756153e-25 2.021251e-23 1 225410291 225410416 126 - 2.726 2.662 -0.211
ENSG00000143815 E014 21.3345809 0.0150514979 1.250088e-02 3.473634e-02 1 225410417 225410818 402 - 1.305 1.141 -0.580
ENSG00000143815 E015 599.4937765 0.0001203896 1.794073e-27 2.427727e-25 1 225411337 225411440 104 - 2.714 2.641 -0.245
ENSG00000143815 E016 735.2354643 0.0020979864 2.296705e-12 5.312624e-11 1 225412454 225412645 192 - 2.803 2.720 -0.275
ENSG00000143815 E017 376.5986720 0.0024107748 3.373462e-08 3.763129e-07 1 225415278 225415332 55 - 2.512 2.437 -0.248
ENSG00000143815 E018 1.9145785 0.0073048391 1.860994e-02 4.847514e-02 1 225417550 225417983 434 - 0.480 0.000 -11.495
ENSG00000143815 E019 692.0518657 0.0016139123 5.085489e-18 2.576018e-16 1 225417984 225418180 197 - 2.782 2.665 -0.389
ENSG00000143815 E020 611.7455041 0.0011915857 5.214356e-16 2.044803e-14 1 225419263 225419452 190 - 2.724 2.637 -0.288
ENSG00000143815 E021 238.4712302 0.0001878900 7.967570e-15 2.660730e-13 1 225419715 225419724 10 - 2.319 2.217 -0.342
ENSG00000143815 E022 362.7040408 0.0001421091 2.450243e-21 1.827155e-19 1 225419725 225419795 71 - 2.501 2.401 -0.332
ENSG00000143815 E023 224.8040479 0.0002190916 1.479326e-15 5.470504e-14 1 225419796 225419798 3 - 2.297 2.180 -0.392
ENSG00000143815 E024 540.2456109 0.0002218127 2.477940e-38 7.695709e-36 1 225422077 225422277 201 - 2.680 2.538 -0.473
ENSG00000143815 E025 1.0652105 0.0469431601 2.829608e-01 4.230312e-01 1 225422278 225422427 150 - 0.210 0.482 1.706
ENSG00000143815 E026 164.7580990 0.0004367201 3.464584e-19 2.015832e-17 1 225423911 225423920 10 - 2.177 1.964 -0.715
ENSG00000143815 E027 378.8277881 0.0002602503 2.726701e-39 9.015102e-37 1 225423921 225424089 169 - 2.536 2.331 -0.684
ENSG00000143815 E028 1.5962448 0.2226601955 9.801939e-01 9.916314e-01 1 225427331 225427953 623 - 0.352 0.377 0.148
ENSG00000143815 E029 178.3375906 0.0036793376 8.702121e-13 2.158972e-11 1 225427954 225428106 153 - 2.213 1.986 -0.760
ENSG00000143815 E030 0.4439371 0.0215609822 5.487258e-01 6.785539e-01 1 225428706 225428925 220 - 0.166 0.000 -9.380