ENSG00000143797

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000305997 ENSG00000143797 HEK293_OSMI2_2hA HEK293_TMG_2hB MBOAT2 protein_coding protein_coding 20.14364 7.661153 30.63647 1.04079 1.222685 1.998205 5.421214 1.6624245 9.787910 0.23109419 0.2072333 2.5505329 0.26008750 0.21696667 0.32000000 0.103033333 1.996381e-03 2.258258e-22 FALSE TRUE
ENST00000471753 ENSG00000143797 HEK293_OSMI2_2hA HEK293_TMG_2hB MBOAT2 protein_coding nonsense_mediated_decay 20.14364 7.661153 30.63647 1.04079 1.222685 1.998205 2.279227 1.6144601 2.364576 0.36081943 0.2780909 0.5477097 0.13706667 0.20796667 0.07740000 -0.130566667 3.459006e-04 2.258258e-22 TRUE TRUE
ENST00000473432 ENSG00000143797 HEK293_OSMI2_2hA HEK293_TMG_2hB MBOAT2 protein_coding retained_intron 20.14364 7.661153 30.63647 1.04079 1.222685 1.998205 1.057297 0.3896860 1.497848 0.18835999 0.2989276 1.9155517 0.06227083 0.04646667 0.04843333 0.001966667 9.622784e-01 2.258258e-22   FALSE
ENST00000486484 ENSG00000143797 HEK293_OSMI2_2hA HEK293_TMG_2hB MBOAT2 protein_coding processed_transcript 20.14364 7.661153 30.63647 1.04079 1.222685 1.998205 1.161701 0.0000000 4.774265 0.00000000 0.1567919 8.9021534 0.03737917 0.00000000 0.15656667 0.156566667 2.258258e-22 2.258258e-22 FALSE TRUE
ENST00000494760 ENSG00000143797 HEK293_OSMI2_2hA HEK293_TMG_2hB MBOAT2 protein_coding retained_intron 20.14364 7.661153 30.63647 1.04079 1.222685 1.998205 1.154636 0.1256643 1.876558 0.07234604 0.5448546 3.7976433 0.06151667 0.01743333 0.06060000 0.043166667 2.098369e-01 2.258258e-22 FALSE FALSE
MSTRG.17914.3 ENSG00000143797 HEK293_OSMI2_2hA HEK293_TMG_2hB MBOAT2 protein_coding   20.14364 7.661153 30.63647 1.04079 1.222685 1.998205 4.982002 2.6507901 7.653599 0.49537172 0.8905833 1.5261673 0.26142500 0.35310000 0.25256667 -0.100533333 5.700720e-01 2.258258e-22 FALSE TRUE
MSTRG.17914.4 ENSG00000143797 HEK293_OSMI2_2hA HEK293_TMG_2hB MBOAT2 protein_coding   20.14364 7.661153 30.63647 1.04079 1.222685 1.998205 1.365086 0.5814924 0.550256 0.30340831 0.5502560 -0.0782735 0.07027917 0.07820000 0.01666667 -0.061533333 4.131747e-01 2.258258e-22 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000143797 E001 742.3284053 0.0001193012 2.162161e-20 1.447914e-18 2 8852690 8858348 5659 - 2.837 2.713 -0.414
ENSG00000143797 E002 116.9550966 0.0081677676 3.892702e-05 2.250140e-04 2 8858349 8858434 86 - 1.937 2.184 0.829
ENSG00000143797 E003 99.0717812 0.0076731347 5.670263e-05 3.151113e-04 2 8858435 8858488 54 - 1.867 2.110 0.816
ENSG00000143797 E004 236.7154119 0.0001785992 4.104877e-17 1.848483e-15 2 8858489 8858846 358 - 2.252 2.468 0.719
ENSG00000143797 E005 64.2867158 0.0021954903 2.859364e-03 9.851022e-03 2 8858847 8858858 12 - 1.710 1.876 0.562
ENSG00000143797 E006 87.1752389 0.0003880309 5.292224e-05 2.964068e-04 2 8858859 8858904 46 - 1.835 2.012 0.597
ENSG00000143797 E007 102.1953537 0.0002896988 1.005521e-06 8.336671e-06 2 8860613 8860694 82 - 1.899 2.094 0.655
ENSG00000143797 E008 89.4393956 0.0003489602 3.488184e-03 1.169119e-02 2 8860695 8860764 70 - 1.860 1.991 0.440
ENSG00000143797 E009 8.7021774 0.0266248741 7.087485e-01 8.063216e-01 2 8860765 8861142 378 - 0.918 0.986 0.254
ENSG00000143797 E010 8.5347263 0.0020324826 2.952125e-01 4.363401e-01 2 8862271 8862322 52 - 0.881 1.016 0.508
ENSG00000143797 E011 3.3248474 0.2473353381 3.822333e-01 5.264674e-01 2 8862323 8862325 3 - 0.505 0.745 1.052
ENSG00000143797 E012 11.1068650 0.0016276832 1.757137e-01 2.956133e-01 2 8862326 8862589 264 - 1.054 0.897 -0.585
ENSG00000143797 E013 123.0956871 0.0003215987 2.171950e-03 7.756039e-03 2 8862590 8862722 133 - 1.999 2.118 0.398
ENSG00000143797 E014 74.0737266 0.0003823139 3.187915e-01 4.617709e-01 2 8864170 8864234 65 - 1.799 1.855 0.190
ENSG00000143797 E015 97.0745526 0.0003246271 6.197442e-01 7.370796e-01 2 8868446 8868549 104 - 1.923 1.953 0.101
ENSG00000143797 E016 99.3838958 0.0043571596 1.239058e-01 2.255383e-01 2 8873108 8873193 86 - 1.956 1.875 -0.274
ENSG00000143797 E017 117.7908237 0.0013652108 1.313050e-02 3.621122e-02 2 8873194 8873300 107 - 2.033 1.932 -0.338
ENSG00000143797 E018 0.3697384 0.0274424043 2.434100e-02 6.051771e-02 2 8876987 8877029 43 - 0.000 0.352 11.328
ENSG00000143797 E019 113.8733653 0.0002533749 1.583721e-04 7.844364e-04 2 8877030 8877121 92 - 2.030 1.885 -0.488
ENSG00000143797 E020 110.7910086 0.0002480338 1.015315e-03 4.011773e-03 2 8877122 8877213 92 - 2.014 1.888 -0.422
ENSG00000143797 E021 90.4150606 0.0002958187 1.021748e-04 5.320410e-04 2 8882511 8882565 55 - 1.934 1.763 -0.578
ENSG00000143797 E022 79.1737178 0.0003370744 6.671220e-04 2.778164e-03 2 8888018 8888073 56 - 1.877 1.718 -0.535
ENSG00000143797 E023 1.5916731 0.0096765512 1.158361e-04 5.947909e-04 2 8908154 8908383 230 - 0.127 0.778 3.882
ENSG00000143797 E024 95.2289224 0.0002954886 3.965204e-03 1.304590e-02 2 8908621 8908716 96 - 1.950 1.832 -0.396
ENSG00000143797 E025 74.5636521 0.0004523837 1.852760e-01 3.078433e-01 2 8943187 8943264 78 - 1.832 1.776 -0.186
ENSG00000143797 E026 69.1309323 0.0004243928 3.299344e-03 1.114709e-02 2 8958497 8958642 146 - 1.815 1.669 -0.494
ENSG00000143797 E027 1.0351353 0.0525332354 6.988527e-01 7.987231e-01 2 8974359 8974435 77 - 0.266 0.351 0.555
ENSG00000143797 E028 45.4040682 0.0120763283 3.201133e-01 4.632286e-01 2 9003540 9003750 211 - 1.621 1.535 -0.293