ENSG00000143786

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000272133 ENSG00000143786 HEK293_OSMI2_2hA HEK293_TMG_2hB CNIH3 protein_coding protein_coding 6.456907 10.80414 4.238136 0.4518599 0.04306024 -1.348018 0.9178242 1.4902257 0.4613581 0.29280993 0.13321823 -1.6702842 0.14925833 0.13846667 0.1085667 -0.02990000 0.797707165 0.003166081 FALSE TRUE
ENST00000483512 ENSG00000143786 HEK293_OSMI2_2hA HEK293_TMG_2hB CNIH3 protein_coding processed_transcript 6.456907 10.80414 4.238136 0.4518599 0.04306024 -1.348018 0.4450161 0.5991115 0.3604639 0.12250254 0.19559850 -0.7173733 0.06811250 0.05643333 0.0842000 0.02776667 0.894424131 0.003166081   FALSE
MSTRG.3131.4 ENSG00000143786 HEK293_OSMI2_2hA HEK293_TMG_2hB CNIH3 protein_coding   6.456907 10.80414 4.238136 0.4518599 0.04306024 -1.348018 1.0866497 1.0970155 0.9498016 0.17003959 0.05685419 -0.2058673 0.18095417 0.10140000 0.2244000 0.12300000 0.004256045 0.003166081   FALSE
MSTRG.3131.5 ENSG00000143786 HEK293_OSMI2_2hA HEK293_TMG_2hB CNIH3 protein_coding   6.456907 10.80414 4.238136 0.4518599 0.04306024 -1.348018 2.5959452 5.5029385 1.1555304 0.58684616 0.15648664 -2.2418349 0.37199167 0.50673333 0.2731667 -0.23356667 0.004169150 0.003166081   FALSE
MSTRG.3131.8 ENSG00000143786 HEK293_OSMI2_2hA HEK293_TMG_2hB CNIH3 protein_coding   6.456907 10.80414 4.238136 0.4518599 0.04306024 -1.348018 0.3638192 0.5604675 0.5046440 0.02487821 0.09214414 -0.1485697 0.05990417 0.05206667 0.1191333 0.06706667 0.035080493 0.003166081   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000143786 E001 0.5202097 0.020848960 1.291585e-01 2.330018e-01 1 224434298 224434441 144 + 0.330 0.074 -2.610
ENSG00000143786 E002 1.5134246 0.010693140 5.674013e-01 6.942206e-01 1 224434660 224434719 60 + 0.433 0.326 -0.612
ENSG00000143786 E003 4.3165356 0.015056244 5.340735e-01 6.661835e-01 1 224434720 224434833 114 + 0.585 0.689 0.451
ENSG00000143786 E004 2.8428518 0.009216164 1.896009e-01 3.132545e-01 1 224434834 224434837 4 + 0.330 0.578 1.291
ENSG00000143786 E005 3.3942946 0.005336188 9.709008e-02 1.860289e-01 1 224434838 224434862 25 + 0.330 0.638 1.556
ENSG00000143786 E006 4.7855390 0.003415193 6.461157e-01 7.581162e-01 1 224434912 224434924 13 + 0.744 0.674 -0.290
ENSG00000143786 E007 12.5162135 0.001516763 9.879264e-01 9.965020e-01 1 224434925 224434964 40 + 1.051 1.051 -0.001
ENSG00000143786 E008 54.0271915 0.001008213 5.272538e-01 6.603697e-01 1 224434965 224435187 223 + 1.629 1.661 0.111
ENSG00000143786 E009 12.8870434 0.001929887 1.798956e-02 4.710984e-02 1 224439634 224439774 141 + 1.243 1.013 -0.828
ENSG00000143786 E010 1.6104123 0.014941311 2.090650e-02 5.339275e-02 1 224451871 224451974 104 + 0.645 0.242 -2.196
ENSG00000143786 E011 4.2654191 0.004742802 9.794902e-02 1.873881e-01 1 224454278 224454343 66 + 0.825 0.579 -1.026
ENSG00000143786 E012 6.4844529 0.007629650 4.105222e-07 3.694290e-06 1 224456854 224456921 68 + 1.199 0.579 -2.408
ENSG00000143786 E013 12.8165600 0.001776760 5.255494e-04 2.255074e-03 1 224459143 224459291 149 + 1.296 0.963 -1.197
ENSG00000143786 E014 1.1426420 0.407806653 1.661941e-01 2.832549e-01 1 224513688 224513780 93 + 0.516 0.194 -2.018
ENSG00000143786 E015 3.6234069 0.007960063 7.559562e-02 1.524604e-01 1 224513781 224513936 156 + 0.787 0.510 -1.195
ENSG00000143786 E016 61.6651737 0.003005176 3.300558e-03 1.115060e-02 1 224515741 224515861 121 + 1.573 1.740 0.568
ENSG00000143786 E017 32.6793465 0.002883161 9.214498e-03 2.682081e-02 1 224515862 224515876 15 + 1.270 1.473 0.703
ENSG00000143786 E018 48.6240617 0.000601176 5.231035e-02 1.132718e-01 1 224521000 224521327 328 + 1.517 1.629 0.382
ENSG00000143786 E019 3.7483445 0.004485908 1.315925e-01 2.363530e-01 1 224521328 224521555 228 + 0.787 0.557 -0.975
ENSG00000143786 E020 0.5117906 0.195068213 1.767711e-01 2.970414e-01 1 224522069 224522134 66 + 0.330 0.075 -2.590
ENSG00000143786 E021 0.0000000       1 224529191 224529195 5 +      
ENSG00000143786 E022 0.0000000       1 224529196 224529217 22 +      
ENSG00000143786 E023 0.0000000       1 224529218 224529221 4 +      
ENSG00000143786 E024 0.0000000       1 224529222 224529222 1 +      
ENSG00000143786 E025 0.0000000       1 224529223 224529309 87 +      
ENSG00000143786 E026 0.0000000       1 224529310 224529420 111 +      
ENSG00000143786 E027 2.1475712 0.047223883 5.423999e-01 6.731656e-01 1 224536936 224537582 647 + 0.516 0.398 -0.601
ENSG00000143786 E028 1.0736416 0.014707147 8.112999e-01 8.802624e-01 1 224546829 224546939 111 + 0.330 0.285 -0.295
ENSG00000143786 E029 0.0000000       1 224565365 224565822 458 +      
ENSG00000143786 E030 0.7458221 0.026293373 1.068226e-02 3.041134e-02 1 224566199 224566264 66 + 0.515 0.074 -3.615
ENSG00000143786 E031 0.5879639 0.021927964 3.707192e-02 8.560450e-02 1 224583164 224583267 104 + 0.432 0.074 -3.199
ENSG00000143786 E032 0.0000000       1 224587140 224587165 26 +      
ENSG00000143786 E033 0.2934659 0.028995227 4.168188e-01   1 224587166 224587420 255 + 0.196 0.074 -1.614
ENSG00000143786 E034 0.5879639 0.021927964 3.707192e-02 8.560450e-02 1 224588361 224588616 256 + 0.432 0.074 -3.199
ENSG00000143786 E035 20.2769883 0.016778594 2.624916e-01 4.002757e-01 1 224616317 224617255 939 + 1.149 1.265 0.412
ENSG00000143786 E036 0.0000000       1 224661313 224661443 131 +      
ENSG00000143786 E037 0.0000000       1 224664754 224664877 124 +      
ENSG00000143786 E038 6.1358174 0.002781866 1.291060e-01 2.329383e-01 1 224680958 224681026 69 + 0.585 0.819 0.973
ENSG00000143786 E039 5.5091317 0.003068698 3.272001e-02 7.723861e-02 1 224684796 224684843 48 + 0.432 0.793 1.611
ENSG00000143786 E040 9.1520588 0.002114407 9.091069e-01 9.462742e-01 1 224730462 224730574 113 + 0.924 0.936 0.045
ENSG00000143786 E041 12.3260567 0.002326219 6.491971e-01 7.605212e-01 1 224734563 224734706 144 + 1.093 1.043 -0.181
ENSG00000143786 E042 56.8282656 0.004392617 4.276731e-01 5.705219e-01 1 224739329 224740554 1226 + 1.718 1.671 -0.157