ENSG00000143776

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000366766 ENSG00000143776 HEK293_OSMI2_2hA HEK293_TMG_2hB CDC42BPA protein_coding protein_coding 8.76248 4.618149 11.73561 0.2412146 0.05052308 1.343614 0.2665884 0.6986232 0.00000000 0.2166083 0.00000000 -6.146947 0.05330417 0.15520000 0.000000000 -0.15520000 5.838759e-08 6.389615e-31 FALSE TRUE
ENST00000366767 ENSG00000143776 HEK293_OSMI2_2hA HEK293_TMG_2hB CDC42BPA protein_coding protein_coding 8.76248 4.618149 11.73561 0.2412146 0.05052308 1.343614 0.5498835 0.1578748 0.92831736 0.0858861 0.15633851 2.482690 0.05870833 0.03246667 0.079000000 0.04653333 4.053780e-01 6.389615e-31 FALSE TRUE
ENST00000366769 ENSG00000143776 HEK293_OSMI2_2hA HEK293_TMG_2hB CDC42BPA protein_coding protein_coding 8.76248 4.618149 11.73561 0.2412146 0.05052308 1.343614 3.8204234 0.7001870 6.03964194 0.3511071 0.12129425 3.090579 0.37106250 0.14406667 0.514700000 0.37063333 2.186131e-01 6.389615e-31 FALSE TRUE
ENST00000442054 ENSG00000143776 HEK293_OSMI2_2hA HEK293_TMG_2hB CDC42BPA protein_coding protein_coding 8.76248 4.618149 11.73561 0.2412146 0.05052308 1.343614 1.7699944 0.0000000 3.68758783 0.0000000 0.08710682 8.530441 0.15198333 0.00000000 0.314233333 0.31423333 6.389615e-31 6.389615e-31 FALSE TRUE
ENST00000448940 ENSG00000143776 HEK293_OSMI2_2hA HEK293_TMG_2hB CDC42BPA protein_coding protein_coding 8.76248 4.618149 11.73561 0.2412146 0.05052308 1.343614 1.5867815 2.7536955 0.04892697 0.1574523 0.04892697 -5.551527 0.28871250 0.60240000 0.004133333 -0.59826667 4.708322e-09 6.389615e-31 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000143776 E001 0.3686942 0.0303982797 4.852651e-01 6.231666e-01 1 226989865 226989865 1 - 0.071 0.203 1.738
ENSG00000143776 E002 609.4647077 0.0090694797 2.166285e-25 2.455992e-23 1 226989866 226993626 3761 - 2.533 3.036 1.676
ENSG00000143776 E003 157.2430460 0.0023569386 2.279939e-04 1.083250e-03 1 226993627 226994236 610 - 2.067 2.309 0.809
ENSG00000143776 E004 68.7398920 0.0115015147 5.778907e-01 7.030682e-01 1 226994237 226994399 163 - 1.747 1.891 0.486
ENSG00000143776 E005 66.8312485 0.0003930029 8.515629e-02 1.676585e-01 1 226994823 226994980 158 - 1.721 1.906 0.626
ENSG00000143776 E006 0.7760110 0.0156926845 5.640629e-01 6.914404e-01 1 227004055 227004993 939 - 0.186 0.340 1.149
ENSG00000143776 E007 54.7587400 0.0069467817 4.428028e-02 9.889731e-02 1 227004994 227005111 118 - 1.618 1.849 0.784
ENSG00000143776 E008 0.5838113 0.4270282210 1.000000e+00 1.000000e+00 1 227010878 227011063 186 - 0.185 0.199 0.126
ENSG00000143776 E009 52.4808517 0.0046891435 3.775488e-01 5.218872e-01 1 227016080 227016197 118 - 1.627 1.786 0.538
ENSG00000143776 E010 51.1520346 0.0006232254 1.257456e-01 2.282097e-01 1 227016927 227017050 124 - 1.603 1.790 0.634
ENSG00000143776 E011 36.2513156 0.0009314077 1.020543e-01 1.936428e-01 1 227023263 227023347 85 - 1.452 1.658 0.707
ENSG00000143776 E012 45.4139658 0.0100744901 6.091893e-01 7.287169e-01 1 227026055 227026152 98 - 1.572 1.716 0.489
ENSG00000143776 E013 110.2429098 0.0003283684 6.203093e-02 1.300397e-01 1 227028657 227029059 403 - 1.983 2.021 0.128
ENSG00000143776 E014 61.1808534 0.0004241906 1.639931e-03 6.089017e-03 1 227029060 227029250 191 - 1.756 1.701 -0.185
ENSG00000143776 E015 33.3053174 0.0089426877 8.355400e-02 1.651098e-01 1 227030408 227030470 63 - 1.491 1.453 -0.131
ENSG00000143776 E016 55.5871865 0.0010966904 5.691809e-03 1.779513e-02 1 227031298 227031514 217 - 1.710 1.664 -0.156
ENSG00000143776 E017 32.5960240 0.0006161743 4.485483e-01 5.898314e-01 1 227033334 227033415 82 - 1.457 1.512 0.187
ENSG00000143776 E018 44.9167214 0.0009459873 8.355092e-01 8.971280e-01 1 227034655 227034794 140 - 1.581 1.675 0.321
ENSG00000143776 E019 57.9452458 0.0011709119 3.262921e-01 4.697443e-01 1 227035471 227035607 137 - 1.699 1.755 0.188
ENSG00000143776 E020 63.9400304 0.0031379296 6.415781e-04 2.685960e-03 1 227040131 227040236 106 - 1.780 1.692 -0.299
ENSG00000143776 E021 57.3141337 0.0054056031 1.952470e-02 5.046656e-02 1 227047927 227048010 84 - 1.721 1.682 -0.132
ENSG00000143776 E022 13.2203618 0.0013138746 4.232336e-02 9.531402e-02 1 227051881 227051985 105 - 1.136 1.021 -0.415
ENSG00000143776 E023 0.0000000       1 227059213 227059372 160 -      
ENSG00000143776 E024 0.0000000       1 227059373 227059389 17 -      
ENSG00000143776 E025 0.0000000       1 227059390 227059411 22 -      
ENSG00000143776 E026 0.0000000       1 227068467 227068653 187 -      
ENSG00000143776 E027 0.2987644 0.0271134861 6.122975e-01   1 227068654 227068701 48 - 0.133 0.000 -9.216
ENSG00000143776 E028 0.1515154 0.0428613561 1.000000e+00   1 227068702 227069776 1075 - 0.071 0.000 -8.216
ENSG00000143776 E029 45.9957390 0.0005196747 1.530638e-02 4.118141e-02 1 227069777 227069853 77 - 1.627 1.591 -0.123
ENSG00000143776 E030 41.5413875 0.0021907956 4.987058e-03 1.589340e-02 1 227072208 227072299 92 - 1.597 1.519 -0.264
ENSG00000143776 E031 54.5534414 0.0114343038 1.624081e-03 6.037979e-03 1 227073864 227074012 149 - 1.724 1.592 -0.451
ENSG00000143776 E032 52.5820540 0.0074917201 3.160181e-03 1.073820e-02 1 227074259 227074364 106 - 1.698 1.600 -0.331
ENSG00000143776 E033 51.6083707 0.0049832100 4.634764e-04 2.020020e-03 1 227080893 227081017 125 - 1.698 1.572 -0.429
ENSG00000143776 E034 50.5324359 0.0004537787 9.989010e-09 1.232184e-07 1 227091886 227091991 106 - 1.712 1.470 -0.825
ENSG00000143776 E035 67.5827665 0.0008039841 3.054308e-08 3.432646e-07 1 227100992 227101239 248 - 1.825 1.641 -0.622
ENSG00000143776 E036 0.8210624 0.1474638263 1.754974e-01 2.953151e-01 1 227111984 227112311 328 - 0.133 0.443 2.308
ENSG00000143776 E037 46.3580260 0.0005006464 1.277489e-04 6.488900e-04 1 227112312 227112422 111 - 1.652 1.527 -0.426
ENSG00000143776 E038 59.5051261 0.0113797866 6.123534e-05 3.375579e-04 1 227112671 227112913 243 - 1.774 1.578 -0.664
ENSG00000143776 E039 47.3973430 0.0004789445 8.260360e-08 8.526674e-07 1 227119804 227119937 134 - 1.680 1.452 -0.780
ENSG00000143776 E040 42.8446800 0.0005818199 2.432550e-07 2.293532e-06 1 227129109 227129231 123 - 1.638 1.404 -0.802
ENSG00000143776 E041 50.5453103 0.0004570540 8.937698e-10 1.337034e-08 1 227139576 227139742 167 - 1.715 1.443 -0.928
ENSG00000143776 E042 32.3614308 0.0045548321 3.350152e-05 1.968660e-04 1 227142945 227143024 80 - 1.520 1.289 -0.800
ENSG00000143776 E043 60.9804437 0.0108735088 1.716016e-04 8.419947e-04 1 227145489 227145737 249 - 1.776 1.607 -0.572
ENSG00000143776 E044 56.1823967 0.0077397192 2.831314e-07 2.634110e-06 1 227147359 227147559 201 - 1.760 1.496 -0.899
ENSG00000143776 E045 40.0363448 0.0006301632 3.307513e-04 1.503716e-03 1 227160543 227160636 94 - 1.589 1.461 -0.438
ENSG00000143776 E046 0.1451727 0.0431566344 1.000000e+00   1 227193651 227193785 135 - 0.071 0.000 -8.216
ENSG00000143776 E047 40.9340156 0.0052071584 4.332377e-05 2.477828e-04 1 227193786 227193934 149 - 1.614 1.415 -0.684
ENSG00000143776 E048 38.0754037 0.0009744107 6.215891e-08 6.574262e-07 1 227199557 227199652 96 - 1.597 1.314 -0.975
ENSG00000143776 E049 30.7874098 0.0012615265 9.748441e-05 5.102257e-04 1 227213136 227213219 84 - 1.493 1.301 -0.666
ENSG00000143776 E050 2.3209478 0.0276343128 9.433519e-01 9.684716e-01 1 227219263 227219420 158 - 0.445 0.530 0.422
ENSG00000143776 E051 33.3674753 0.0007229859 1.658150e-03 6.148169e-03 1 227254064 227254155 92 - 1.510 1.394 -0.402
ENSG00000143776 E052 86.7200234 0.0068379712 1.710452e-09 2.427447e-08 1 227317005 227318492 1488 - 1.945 1.678 -0.903