ENSG00000143740

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000478768 ENSG00000143740 HEK293_OSMI2_2hA HEK293_TMG_2hB SNAP47 protein_coding protein_coding 74.29106 122.0879 46.44303 7.182591 0.8774482 -1.394194 18.801913 26.479116 15.350576 3.871581 0.4098436 -0.7861673 0.27664167 0.21523333 0.33046667 0.11523333 0.003378935 0.003378935 FALSE TRUE
ENST00000617596 ENSG00000143740 HEK293_OSMI2_2hA HEK293_TMG_2hB SNAP47 protein_coding protein_coding 74.29106 122.0879 46.44303 7.182591 0.8774482 -1.394194 44.281038 75.729705 24.183542 2.232985 0.2798534 -1.6464278 0.57155000 0.62243333 0.52110000 -0.10133333 0.014952237 0.003378935 FALSE TRUE
ENST00000681929 ENSG00000143740 HEK293_OSMI2_2hA HEK293_TMG_2hB SNAP47 protein_coding protein_coding 74.29106 122.0879 46.44303 7.182591 0.8774482 -1.394194 5.213444 9.850992 3.083683 1.985794 0.6018969 -1.6724075 0.07234167 0.07963333 0.06596667 -0.01366667 0.797666656 0.003378935 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000143740 E001 0.0000000       1 227728200 227728284 85 +      
ENSG00000143740 E002 0.0000000       1 227728539 227728548 10 +      
ENSG00000143740 E003 0.0000000       1 227728549 227728598 50 +      
ENSG00000143740 E004 0.1817044 0.0401080794 1.000000e+00   1 227728599 227728617 19 + 0.000 0.073 9.184
ENSG00000143740 E005 0.6235652 0.0237514186 3.442519e-02 8.057013e-02 1 227728618 227728634 17 + 0.437 0.073 -3.240
ENSG00000143740 E006 1.5759820 0.0125724640 8.053831e-02 1.603951e-01 1 227728635 227728640 6 + 0.590 0.282 -1.657
ENSG00000143740 E007 4.2192483 0.0057466118 1.076798e-01 2.021145e-01 1 227728641 227728656 16 + 0.831 0.594 -0.979
ENSG00000143740 E008 7.9686198 0.0021985617 8.084502e-01 8.783231e-01 1 227728657 227728685 29 + 0.899 0.870 -0.111
ENSG00000143740 E009 7.9686198 0.0021985617 8.084502e-01 8.783231e-01 1 227728686 227728687 2 + 0.899 0.870 -0.111
ENSG00000143740 E010 7.9686198 0.0021985617 8.084502e-01 8.783231e-01 1 227728688 227728689 2 + 0.899 0.870 -0.111
ENSG00000143740 E011 9.5164616 0.0026973049 4.420164e-01 5.836831e-01 1 227728690 227728706 17 + 1.010 0.921 -0.333
ENSG00000143740 E012 13.1699833 0.0013598912 1.787677e-01 2.996053e-01 1 227728707 227728786 80 + 1.172 1.037 -0.486
ENSG00000143740 E013 10.7793964 0.0017635983 2.720451e-01 4.108818e-01 1 227731585 227731712 128 + 1.078 0.958 -0.444
ENSG00000143740 E014 5.1834903 0.0142271690 9.962186e-01 1.000000e+00 1 227731713 227731747 35 + 0.703 0.704 0.004
ENSG00000143740 E015 41.4242057 0.0005336676 1.482513e-01 2.592995e-01 1 227732389 227733518 1130 + 1.605 1.517 -0.300
ENSG00000143740 E016 38.1220465 0.0080726636 5.194540e-01 6.535547e-01 1 227733519 227734352 834 + 1.538 1.488 -0.173
ENSG00000143740 E017 5.0823117 0.0287909660 7.422652e-01 8.312049e-01 1 227734996 227735004 9 + 0.650 0.706 0.234
ENSG00000143740 E018 19.6807354 0.0457536748 5.847461e-01 7.085963e-01 1 227735005 227735427 423 + 1.277 1.207 -0.249
ENSG00000143740 E019 6.4320054 0.0723859958 1.844143e-01 3.067639e-01 1 227735428 227735430 3 + 0.959 0.724 -0.916
ENSG00000143740 E020 8.1334640 0.0845863125 2.479205e-01 3.834795e-01 1 227735431 227735434 4 + 1.035 0.820 -0.814
ENSG00000143740 E021 8.3151684 0.0762066563 2.606646e-01 3.982301e-01 1 227735435 227735435 1 + 1.035 0.831 -0.768
ENSG00000143740 E022 165.9503677 0.0038071528 2.106620e-06 1.630614e-05 1 227735436 227735474 39 + 2.280 2.082 -0.663
ENSG00000143740 E023 248.5324240 0.0022706588 1.630092e-07 1.589869e-06 1 227735475 227735499 25 + 2.437 2.263 -0.580
ENSG00000143740 E024 0.0000000       1 227735681 227735684 4 +      
ENSG00000143740 E025 2.0367562 0.0161591813 8.850366e-02 1.728360e-01 1 227735685 227735730 46 + 0.650 0.358 -1.438
ENSG00000143740 E026 1.2565659 0.0652605290 3.094551e-01 4.517529e-01 1 227736173 227736487 315 + 0.437 0.241 -1.227
ENSG00000143740 E027 2.7927028 0.0054671940 2.521845e-01 3.885079e-01 1 227739206 227739222 17 + 0.333 0.552 1.152
ENSG00000143740 E028 3.5258500 0.0043949909 1.109344e-01 2.069236e-01 1 227739223 227739302 80 + 0.333 0.634 1.515
ENSG00000143740 E029 1044.2004933 0.0017695630 3.918982e-03 1.291558e-02 1 227747692 227748062 371 + 2.977 2.916 -0.203
ENSG00000143740 E030 817.9918674 0.0001340789 1.552614e-01 2.687469e-01 1 227748063 227748233 171 + 2.840 2.821 -0.062
ENSG00000143740 E031 0.3697384 0.0251808602 7.617738e-01 8.455539e-01 1 227749249 227749305 57 + 0.000 0.136 11.387
ENSG00000143740 E032 0.1515154 0.0439308443 1.458086e-01   1 227758606 227758659 54 + 0.198 0.000 -13.073
ENSG00000143740 E033 1917.9272074 0.0001160146 1.787341e-02 4.686528e-02 1 227758995 227759485 491 + 3.176 3.200 0.080
ENSG00000143740 E034 1.3263199 0.0116061559 7.325264e-02 1.487214e-01 1 227759486 227759652 167 + 0.000 0.392 13.557
ENSG00000143740 E035 1.1342099 0.0169211648 6.635598e-02 1.373138e-01 1 227763739 227763802 64 + 0.520 0.190 -2.070
ENSG00000143740 E036 0.8459408 0.0173182347 4.355219e-01 5.777570e-01 1 227766072 227766130 59 + 0.333 0.190 -1.070
ENSG00000143740 E037 957.3385987 0.0006520742 1.118782e-02 3.161543e-02 1 227766959 227767083 125 + 2.857 2.902 0.150
ENSG00000143740 E038 33.0438735 0.0464690645 2.821991e-01 4.221688e-01 1 227767084 227768248 1165 + 1.561 1.407 -0.528
ENSG00000143740 E039 12.2334797 0.0014990992 1.097628e-03 4.295709e-03 1 227768249 227768364 116 + 1.277 0.957 -1.151
ENSG00000143740 E040 41.4404265 0.0006856475 2.757154e-04 1.280891e-03 1 227768365 227769516 1152 + 1.705 1.492 -0.725
ENSG00000143740 E041 6.0744850 0.0041621372 1.817361e-01 3.034084e-01 1 227770417 227770532 116 + 0.899 0.718 -0.715
ENSG00000143740 E042 19.9344736 0.0414817433 5.331463e-01 6.653906e-01 1 227770571 227770744 174 + 1.290 1.210 -0.283
ENSG00000143740 E043 60.4267772 0.0169103619 7.366957e-01 8.271094e-01 1 227775789 227776970 1182 + 1.715 1.689 -0.085
ENSG00000143740 E044 1993.1778289 0.0006553767 1.930570e-08 2.258355e-07 1 227780527 227781826 1300 + 3.151 3.225 0.243