ENSG00000143643

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000366661 ENSG00000143643 HEK293_OSMI2_2hA HEK293_TMG_2hB TTC13 protein_coding protein_coding 17.68746 9.389625 21.83195 0.2083372 0.9494854 1.216427 7.3675682 3.6313178 9.3482823 0.59128849 0.3493179 1.3617831 0.40015417 0.38440000 0.42846667 0.04406667 0.7717902002 0.0005933161 FALSE TRUE
ENST00000366662 ENSG00000143643 HEK293_OSMI2_2hA HEK293_TMG_2hB TTC13 protein_coding protein_coding 17.68746 9.389625 21.83195 0.2083372 0.9494854 1.216427 2.2510725 1.6529790 2.7777104 0.36467123 0.1025170 0.7453108 0.12502917 0.17513333 0.12736667 -0.04776667 0.5307759519 0.0005933161 FALSE TRUE
ENST00000471302 ENSG00000143643 HEK293_OSMI2_2hA HEK293_TMG_2hB TTC13 protein_coding retained_intron 17.68746 9.389625 21.83195 0.2083372 0.9494854 1.216427 0.8134208 0.0000000 1.5471405 0.00000000 0.7989847 7.2827554 0.04823333 0.00000000 0.06810000 0.06810000 0.0005933161 0.0005933161 FALSE TRUE
ENST00000519379 ENSG00000143643 HEK293_OSMI2_2hA HEK293_TMG_2hB TTC13 protein_coding retained_intron 17.68746 9.389625 21.83195 0.2083372 0.9494854 1.216427 1.4576686 0.3447107 2.0760906 0.07350406 0.2615377 2.5560873 0.08742083 0.03656667 0.09553333 0.05896667 0.0147885187 0.0005933161   FALSE
MSTRG.3262.4 ENSG00000143643 HEK293_OSMI2_2hA HEK293_TMG_2hB TTC13 protein_coding   17.68746 9.389625 21.83195 0.2083372 0.9494854 1.216427 2.3637672 1.3221565 2.7624113 0.57355960 0.2137028 1.0573778 0.13220833 0.14303333 0.12646667 -0.01656667 0.9879053192 0.0005933161 FALSE TRUE
MSTRG.3262.5 ENSG00000143643 HEK293_OSMI2_2hA HEK293_TMG_2hB TTC13 protein_coding   17.68746 9.389625 21.83195 0.2083372 0.9494854 1.216427 1.6076606 1.9722930 0.9638159 0.68488825 0.1152334 -1.0254493 0.10523333 0.21086667 0.04423333 -0.16663333 0.0134364381 0.0005933161 FALSE TRUE
MSTRG.3262.7 ENSG00000143643 HEK293_OSMI2_2hA HEK293_TMG_2hB TTC13 protein_coding   17.68746 9.389625 21.83195 0.2083372 0.9494854 1.216427 0.9546505 0.3177565 1.1827760 0.15011241 0.2030062 1.8636269 0.05934583 0.03440000 0.05483333 0.02043333 0.5802398425 0.0005933161 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000143643 E001 4.4094473 0.0050096573 3.186275e-02 7.558753e-02 1 230903306 230903411 106 - 0.584 0.888 1.246
ENSG00000143643 E002 6.9049275 0.0028776796 6.094663e-03 1.885887e-02 1 230906243 230906278 36 - 0.740 1.070 1.259
ENSG00000143643 E003 86.6056422 0.0123305801 1.265853e-08 1.531171e-07 1 230906279 230906354 76 - 1.743 2.127 1.289
ENSG00000143643 E004 207.5364408 0.0032444353 2.956705e-16 1.200499e-14 1 230906355 230906651 297 - 2.169 2.466 0.993
ENSG00000143643 E005 72.1548328 0.0033585136 3.783610e-06 2.768825e-05 1 230906652 230906683 32 - 1.747 1.982 0.792
ENSG00000143643 E006 66.7237690 0.0008657669 2.560712e-06 1.946886e-05 1 230906684 230906714 31 - 1.726 1.942 0.727
ENSG00000143643 E007 168.8766664 0.0002574877 6.789524e-13 1.712495e-11 1 230906715 230906949 235 - 2.129 2.332 0.679
ENSG00000143643 E008 96.8639327 0.0016175737 9.343878e-04 3.734661e-03 1 230906950 230907019 70 - 1.920 2.060 0.469
ENSG00000143643 E009 102.4376517 0.0003729065 5.477378e-03 1.722822e-02 1 230908712 230908791 80 - 1.961 2.067 0.354
ENSG00000143643 E010 84.7768485 0.0031382887 9.654902e-03 2.791442e-02 1 230908942 230909020 79 - 1.869 1.996 0.427
ENSG00000143643 E011 0.8105550 0.0139012112 4.741315e-01 6.129826e-01 1 230911377 230911469 93 - 0.289 0.161 -1.075
ENSG00000143643 E012 82.6879573 0.0003567178 3.424916e-03 1.151140e-02 1 230911470 230911549 80 - 1.861 1.982 0.409
ENSG00000143643 E013 117.4270057 0.0003565054 1.620363e-02 4.317238e-02 1 230912623 230912758 136 - 2.029 2.116 0.291
ENSG00000143643 E014 122.8953506 0.0025378309 3.595985e-01 5.039305e-01 1 230916193 230916299 107 - 2.066 2.109 0.146
ENSG00000143643 E015 42.8863587 0.0005117689 1.125984e-01 2.093472e-01 1 230916300 230916302 3 - 1.664 1.582 -0.279
ENSG00000143643 E016 0.1451727 0.0433149194 9.078685e-01   1 230920303 230920509 207 - 0.092 0.001 -7.316
ENSG00000143643 E017 104.2506592 0.0038274647 5.295188e-01 6.622900e-01 1 230920510 230920594 85 - 2.021 1.999 -0.075
ENSG00000143643 E018 91.9030581 0.0019291095 9.436861e-01 9.686742e-01 1 230921421 230921504 84 - 1.957 1.961 0.013
ENSG00000143643 E019 6.0755122 0.0045709392 8.990356e-01 9.395855e-01 1 230921505 230921506 2 - 0.839 0.861 0.086
ENSG00000143643 E020 96.0116664 0.0029917193 3.454685e-01 4.895612e-01 1 230923841 230923933 93 - 1.987 1.950 -0.125
ENSG00000143643 E021 127.8418624 0.0005174685 4.116875e-02 9.319715e-02 1 230924841 230924973 133 - 2.121 2.059 -0.209
ENSG00000143643 E022 112.2900943 0.0004193497 3.704130e-02 8.555048e-02 1 230925517 230925647 131 - 2.069 2.002 -0.224
ENSG00000143643 E023 109.3082610 0.0047660639 4.618312e-02 1.023759e-01 1 230928937 230929093 157 - 2.066 1.977 -0.298
ENSG00000143643 E024 82.1205571 0.0247020930 2.164770e-01 3.461684e-01 1 230931298 230931417 120 - 1.946 1.843 -0.347
ENSG00000143643 E025 58.9014624 0.0143673878 5.417935e-01 6.727215e-01 1 230931418 230931460 43 - 1.780 1.741 -0.133
ENSG00000143643 E026 48.0859299 0.0157117846 7.875249e-01 8.639133e-01 1 230931461 230931472 12 - 1.684 1.669 -0.049
ENSG00000143643 E027 96.0075259 0.0152917428 3.233810e-01 4.667095e-01 1 230931736 230931877 142 - 1.998 1.934 -0.212
ENSG00000143643 E028 41.3075794 0.0006297197 1.221234e-02 3.404146e-02 1 230933779 230933782 4 - 1.662 1.522 -0.475
ENSG00000143643 E029 55.8253049 0.0008488024 4.764727e-04 2.070091e-03 1 230933783 230933815 33 - 1.800 1.626 -0.590
ENSG00000143643 E030 56.0848330 0.0004476706 6.553754e-04 2.735561e-03 1 230933816 230933861 46 - 1.800 1.635 -0.560
ENSG00000143643 E031 8.1845714 0.0350610708 1.851946e-02 4.827266e-02 1 230936158 230936264 107 - 1.057 0.704 -1.358
ENSG00000143643 E032 11.4775349 0.0034200958 5.213779e-04 2.239739e-03 1 230936265 230936637 373 - 1.195 0.805 -1.444
ENSG00000143643 E033 54.8409913 0.0117016332 4.038533e-03 1.324988e-02 1 230939386 230939457 72 - 1.802 1.596 -0.697
ENSG00000143643 E034 56.3008785 0.0027453475 7.882511e-04 3.217110e-03 1 230939458 230939496 39 - 1.805 1.622 -0.619
ENSG00000143643 E035 75.3337557 0.0032554962 6.337810e-06 4.408751e-05 1 230940440 230940508 69 - 1.944 1.715 -0.773
ENSG00000143643 E036 53.6655373 0.0037077863 4.224766e-08 4.624808e-07 1 230940509 230940556 48 - 1.825 1.493 -1.129
ENSG00000143643 E037 48.7922339 0.0012336439 3.536588e-07 3.223149e-06 1 230943806 230943898 93 - 1.773 1.486 -0.978
ENSG00000143643 E038 62.4421145 0.0005467783 1.898460e-11 3.777121e-10 1 230945389 230945454 66 - 1.891 1.556 -1.134
ENSG00000143643 E039 74.7691394 0.0004020574 2.515761e-07 2.365395e-06 1 230954333 230954403 71 - 1.941 1.717 -0.754
ENSG00000143643 E040 1.3349319 0.0098921976 1.050686e-01 1.981857e-01 1 230956421 230956560 140 - 0.461 0.161 -2.077
ENSG00000143643 E041 77.4986268 0.0069089475 1.295304e-03 4.960308e-03 1 230958224 230958299 76 - 1.947 1.763 -0.618
ENSG00000143643 E042 61.1172502 0.0058072998 4.211105e-05 2.414665e-04 1 230961209 230961303 95 - 1.863 1.616 -0.834
ENSG00000143643 E043 46.1923125 0.0027929737 8.120933e-03 2.409004e-02 1 230978560 230978937 378 - 1.714 1.562 -0.520