ENSG00000143621

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361891 ENSG00000143621 HEK293_OSMI2_2hA HEK293_TMG_2hB ILF2 protein_coding protein_coding 522.5475 513.6089 559.1198 113.2497 5.261659 0.1224847 319.16083 383.808237 291.73745 85.423991 11.745515 -0.39570322 0.6150875 0.74513333 0.52150000 -0.223633333 6.901843e-08 6.901843e-08 FALSE TRUE
ENST00000480213 ENSG00000143621 HEK293_OSMI2_2hA HEK293_TMG_2hB ILF2 protein_coding processed_transcript 522.5475 513.6089 559.1198 113.2497 5.261659 0.1224847 61.53027 61.077649 58.84480 24.563319 1.914966 -0.05372062 0.1153500 0.11413333 0.10530000 -0.008833333 9.872518e-01 6.901843e-08   TRUE
MSTRG.2246.4 ENSG00000143621 HEK293_OSMI2_2hA HEK293_TMG_2hB ILF2 protein_coding   522.5475 513.6089 559.1198 113.2497 5.261659 0.1224847 113.69121 60.242393 158.20147 9.657928 11.616585 1.39276379 0.2172875 0.12043333 0.28340000 0.162966667 2.795438e-07 6.901843e-08 FALSE TRUE
MSTRG.2246.6 ENSG00000143621 HEK293_OSMI2_2hA HEK293_TMG_2hB ILF2 protein_coding   522.5475 513.6089 559.1198 113.2497 5.261659 0.1224847 23.75823 7.919394 41.40402 2.544330 5.221952 2.38483678 0.0440750 0.01923333 0.07393333 0.054700000 6.744548e-02 6.901843e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000143621 E001 259.964788 0.0024148293 7.307099e-11 1.318640e-09 1 153661788 153662064 277 - 2.266 2.505 0.796
ENSG00000143621 E002 4779.913344 0.0015520231 4.462591e-14 1.333056e-12 1 153662065 153662352 288 - 3.578 3.734 0.520
ENSG00000143621 E003 3147.145508 0.0013751484 1.954713e-05 1.215541e-04 1 153662353 153662383 31 - 3.437 3.533 0.318
ENSG00000143621 E004 6583.432580 0.0006687968 4.962617e-03 1.582620e-02 1 153662384 153662556 173 - 3.787 3.835 0.160
ENSG00000143621 E005 4399.737231 0.0003820428 6.928078e-01 7.939440e-01 1 153662705 153662795 91 - 3.631 3.651 0.068
ENSG00000143621 E006 4334.833483 0.0013134178 4.690684e-01 6.083714e-01 1 153663019 153663133 115 - 3.635 3.632 -0.010
ENSG00000143621 E007 92.260940 0.0013021553 1.053108e-13 2.982185e-12 1 153663134 153663214 81 - 2.110 1.834 -0.925
ENSG00000143621 E008 3349.245655 0.0012031710 4.032766e-01 5.470553e-01 1 153663215 153663276 62 - 3.526 3.518 -0.025
ENSG00000143621 E009 3536.794444 0.0008569857 5.391758e-01 6.704555e-01 1 153664043 153664130 88 - 3.546 3.546 -0.002
ENSG00000143621 E010 3589.487165 0.0005299377 9.094339e-01 9.464751e-01 1 153664396 153664474 79 - 3.549 3.557 0.025
ENSG00000143621 E011 4607.542512 0.0001888438 3.354450e-02 7.886258e-02 1 153665220 153665336 117 - 3.666 3.663 -0.009
ENSG00000143621 E012 3509.648790 0.0001407980 7.074838e-06 4.866057e-05 1 153665663 153665728 66 - 3.558 3.541 -0.055
ENSG00000143621 E013 5.413467 0.0030196943 1.991558e-03 7.200418e-03 1 153667283 153667554 272 - 0.987 0.607 -1.516
ENSG00000143621 E014 3833.811484 0.0003880272 2.046844e-08 2.382163e-07 1 153667555 153667657 103 - 3.610 3.562 -0.161
ENSG00000143621 E015 3289.774851 0.0009789881 8.575515e-07 7.225608e-06 1 153668000 153668077 78 - 3.555 3.482 -0.243
ENSG00000143621 E016 3226.943803 0.0014243631 1.424923e-02 3.879111e-02 1 153668453 153668557 105 - 3.528 3.488 -0.135
ENSG00000143621 E017 6.458278 0.0481785699 5.540826e-02 1.186871e-01 1 153668558 153668576 19 - 1.017 0.720 -1.146
ENSG00000143621 E018 1954.017314 0.0010199087 6.353521e-02 1.325831e-01 1 153669836 153669878 43 - 3.302 3.280 -0.073
ENSG00000143621 E019 9.998968 0.0310749843 8.756889e-01 9.241496e-01 1 153669879 153669908 30 - 1.046 1.048 0.007
ENSG00000143621 E020 1867.851629 0.0008179017 5.363011e-02 1.156011e-01 1 153670171 153670230 60 - 3.282 3.262 -0.068
ENSG00000143621 E021 6.931870 0.0149331037 6.865062e-01 7.890200e-01 1 153670231 153670232 2 - 0.920 0.885 -0.131
ENSG00000143621 E022 4.314741 0.0037965112 2.861601e-01 4.265618e-01 1 153670886 153670917 32 - 0.794 0.667 -0.516
ENSG00000143621 E023 1053.740753 0.0017710804 2.642108e-02 6.478889e-02 1 153670918 153671031 114 - 3.047 3.001 -0.152