ENSG00000143612

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000350592 ENSG00000143612 HEK293_OSMI2_2hA HEK293_TMG_2hB C1orf43 protein_coding protein_coding 290.6065 351.7007 288.5318 48.41305 5.048884 -0.285609 63.96012 86.077530 69.21057 19.8966518 2.518578 -0.31460342 0.21377917 0.23736667 0.2397333 0.002366667 0.9855866840 0.0006231757 FALSE  
ENST00000362076 ENSG00000143612 HEK293_OSMI2_2hA HEK293_TMG_2hB C1orf43 protein_coding protein_coding 290.6065 351.7007 288.5318 48.41305 5.048884 -0.285609 36.36671 49.670017 22.00163 7.7572485 3.954260 -1.17439991 0.12489167 0.14120000 0.0765000 -0.064700000 0.0579961400 0.0006231757 FALSE  
ENST00000368516 ENSG00000143612 HEK293_OSMI2_2hA HEK293_TMG_2hB C1orf43 protein_coding protein_coding 290.6065 351.7007 288.5318 48.41305 5.048884 -0.285609 20.08600 23.988774 23.04436 3.3255441 1.787739 -0.05792115 0.07087500 0.07293333 0.0799000 0.006966667 0.8609071197 0.0006231757 FALSE  
ENST00000368518 ENSG00000143612 HEK293_OSMI2_2hA HEK293_TMG_2hB C1orf43 protein_coding protein_coding 290.6065 351.7007 288.5318 48.41305 5.048884 -0.285609 22.49961 37.241132 17.92903 5.0703584 2.116453 -1.05418273 0.07615833 0.10596667 0.0619000 -0.044066667 0.0014278997 0.0006231757 FALSE  
ENST00000368519 ENSG00000143612 HEK293_OSMI2_2hA HEK293_TMG_2hB C1orf43 protein_coding protein_coding 290.6065 351.7007 288.5318 48.41305 5.048884 -0.285609 15.26370 9.614974 29.17501 0.5806192 6.216498 1.60037309 0.05342500 0.02836667 0.1005667 0.072200000 0.0006231757 0.0006231757 FALSE  
ENST00000368521 ENSG00000143612 HEK293_OSMI2_2hA HEK293_TMG_2hB C1orf43 protein_coding protein_coding 290.6065 351.7007 288.5318 48.41305 5.048884 -0.285609 117.04191 126.550099 107.38127 16.3904713 3.480170 -0.23694595 0.40777083 0.36116667 0.3727000 0.011533333 0.8848637184 0.0006231757 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000143612 E001 0.923272 0.0136968632 7.618881e-01 8.456412e-01 1 154206696 154206705 10 - 0.253 0.316 0.443
ENSG00000143612 E002 9.025818 0.0037946452 2.739613e-01 4.130616e-01 1 154206706 154206719 14 - 0.908 1.049 0.521
ENSG00000143612 E003 1062.440017 0.0046907775 2.376213e-03 8.387362e-03 1 154206720 154206874 155 - 2.929 3.051 0.407
ENSG00000143612 E004 2832.382024 0.0038167893 3.316920e-03 1.119729e-02 1 154206875 154207097 223 - 3.373 3.467 0.314
ENSG00000143612 E005 1725.937390 0.0021072394 1.027019e-01 1.946224e-01 1 154207098 154207175 78 - 3.191 3.238 0.156
ENSG00000143612 E006 1471.566316 0.0008778950 9.454159e-01 9.697299e-01 1 154207176 154207229 54 - 3.148 3.158 0.034
ENSG00000143612 E007 3687.109902 0.0003534735 1.782909e-03 6.544852e-03 1 154207230 154207539 310 - 3.566 3.546 -0.067
ENSG00000143612 E008 2153.158167 0.0003895492 2.798817e-03 9.671270e-03 1 154207540 154207648 109 - 3.336 3.312 -0.079
ENSG00000143612 E009 6.025729 0.0034752754 1.453380e-03 5.484722e-03 1 154208481 154208517 37 - 1.036 0.653 -1.496
ENSG00000143612 E010 329.743480 0.0024581593 4.238277e-11 7.960825e-10 1 154211734 154212132 399 - 2.353 2.574 0.737
ENSG00000143612 E011 384.620254 0.0027427554 1.860625e-10 3.133521e-09 1 154212133 154212285 153 - 2.426 2.636 0.699
ENSG00000143612 E012 317.277966 0.0019541924 7.291858e-07 6.239479e-06 1 154212286 154212319 34 - 2.383 2.539 0.521
ENSG00000143612 E013 1805.654841 0.0002842763 3.216838e-02 7.618039e-02 1 154212320 154212378 59 - 3.253 3.239 -0.047
ENSG00000143612 E014 2805.281672 0.0009201959 3.570497e-01 5.014743e-01 1 154212458 154212624 167 - 3.439 3.429 -0.033
ENSG00000143612 E015 8.164024 0.0394983046 3.177971e-01 4.606933e-01 1 154212625 154212730 106 - 1.035 0.910 -0.465
ENSG00000143612 E016 8.437058 0.0020239484 8.107442e-05 4.330835e-04 1 154213182 154213303 122 - 1.181 0.766 -1.553
ENSG00000143612 E017 1259.915129 0.0010105082 6.713941e-01 7.776332e-01 1 154213893 154213946 54 - 3.087 3.085 -0.007
ENSG00000143612 E018 2050.219096 0.0008679425 2.295972e-01 3.619580e-01 1 154214457 154214574 118 - 3.305 3.293 -0.042
ENSG00000143612 E019 6.216079 0.0879265454 3.857548e-02 8.840939e-02 1 154218716 154218785 70 - 1.037 0.660 -1.470
ENSG00000143612 E020 1113.742584 0.0008449080 1.511458e-03 5.673270e-03 1 154219836 154219937 102 - 3.064 3.015 -0.160
ENSG00000143612 E021 2.840893 0.0112477534 6.755197e-01 7.807780e-01 1 154219938 154219960 23 - 0.618 0.566 -0.234
ENSG00000143612 E022 1930.218861 0.0016964570 1.069795e-01 2.010790e-01 1 154220342 154220418 77 - 3.290 3.258 -0.105
ENSG00000143612 E023 2010.522402 0.0018322819 1.844270e-03 6.740713e-03 1 154220419 154220637 219 - 3.328 3.263 -0.215