ENSG00000143401

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000583931 ENSG00000143401 HEK293_OSMI2_2hA HEK293_TMG_2hB ANP32E protein_coding protein_coding 65.25542 27.76232 115.4809 0.5425407 4.268607 2.05606 40.285076 20.188765 73.561534 0.8814281 1.576529 1.8648806 0.6468417 0.72756667 0.63790000 -0.08966667 0.19283507 0.008549202 FALSE TRUE
ENST00000616917 ENSG00000143401 HEK293_OSMI2_2hA HEK293_TMG_2hB ANP32E protein_coding protein_coding 65.25542 27.76232 115.4809 0.5425407 4.268607 2.05606 3.435644 2.386961 4.704723 1.3931875 2.811391 0.9759666 0.0542000 0.08423333 0.03966667 -0.04456667 0.91753419 0.008549202 FALSE TRUE
MSTRG.2148.6 ENSG00000143401 HEK293_OSMI2_2hA HEK293_TMG_2hB ANP32E protein_coding   65.25542 27.76232 115.4809 0.5425407 4.268607 2.05606 13.250062 2.493020 22.717998 0.6458753 2.049474 3.1827289 0.1796625 0.09076667 0.19626667 0.10550000 0.03271807 0.008549202 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000143401 E001 0.4513240 0.1818016248 6.802924e-01 7.842096e-01 1 150218417 150218417 1 - 0.129 0.206 0.804
ENSG00000143401 E002 79.9558317 0.0139889266 3.944260e-11 7.446220e-10 1 150218418 150218554 137 - 1.667 2.159 1.657
ENSG00000143401 E003 2240.6003272 0.0029560801 4.175139e-05 2.395782e-04 1 150218555 150220271 1717 - 3.259 3.372 0.375
ENSG00000143401 E004 266.1079875 0.0002219391 4.835277e-02 1.062518e-01 1 150220272 150220377 106 - 2.374 2.344 -0.100
ENSG00000143401 E005 142.7861295 0.0002642174 4.242854e-01 5.672599e-01 1 150220378 150220391 14 - 2.086 2.134 0.163
ENSG00000143401 E006 215.2980518 0.0001822633 3.768439e-02 8.673756e-02 1 150220392 150220460 69 - 2.254 2.333 0.263
ENSG00000143401 E007 314.2493613 0.0004762550 4.057752e-02 9.208210e-02 1 150220461 150220537 77 - 2.420 2.491 0.236
ENSG00000143401 E008 726.1781591 0.0001917766 3.925579e-01 5.365142e-01 1 150220538 150220758 221 - 2.794 2.829 0.117
ENSG00000143401 E009 324.8732410 0.0002070549 3.865816e-01 5.307514e-01 1 150220759 150220761 3 - 2.454 2.456 0.005
ENSG00000143401 E010 535.2413432 0.0001887145 4.869498e-01 6.246609e-01 1 150223186 150223240 55 - 2.668 2.677 0.030
ENSG00000143401 E011 8.7153113 0.0019841450 1.200441e-01 2.200504e-01 1 150223241 150223294 54 - 0.879 1.080 0.744
ENSG00000143401 E012 630.8814102 0.0001233272 7.619167e-02 1.534224e-01 1 150226608 150226672 65 - 2.743 2.735 -0.027
ENSG00000143401 E013 789.4245148 0.0001002281 1.783628e-02 4.678670e-02 1 150226673 150226795 123 - 2.841 2.828 -0.046
ENSG00000143401 E014 424.5559066 0.0001723849 2.691120e-02 6.580336e-02 1 150229072 150229114 43 - 2.575 2.551 -0.081
ENSG00000143401 E015 358.1641360 0.0017108881 5.048349e-01 6.407102e-01 1 150229115 150229144 30 - 2.495 2.495 -0.002
ENSG00000143401 E016 442.9647728 0.0041558320 2.562504e-01 3.932215e-01 1 150229145 150229237 93 - 2.593 2.570 -0.076
ENSG00000143401 E017 462.7771795 0.0015180952 1.202435e-01 2.203358e-01 1 150230571 150230693 123 - 2.611 2.590 -0.071
ENSG00000143401 E018 504.1028033 0.0037484890 1.075831e-02 3.058601e-02 1 150231777 150231926 150 - 2.661 2.592 -0.227
ENSG00000143401 E019 0.7353267 0.0688413160 9.108741e-01 9.473693e-01 1 150234579 150234678 100 - 0.228 0.207 -0.182
ENSG00000143401 E020 443.5473262 0.0005078023 1.937620e-06 1.511846e-05 1 150235733 150235829 97 - 2.609 2.523 -0.287
ENSG00000143401 E021 187.1876877 0.0019525756 1.144147e-04 5.881459e-04 1 150235830 150235833 4 - 2.244 2.117 -0.425
ENSG00000143401 E022 398.3166860 0.0023695620 2.384890e-05 1.453561e-04 1 150235834 150236075 242 - 2.568 2.453 -0.383
ENSG00000143401 E023 98.3865381 0.0028515933 6.230857e-03 1.922159e-02 1 150236076 150236162 87 - 1.965 1.846 -0.400
ENSG00000143401 E024 0.7749789 0.0148998757 7.948146e-02 1.587107e-01 1 150236163 150236263 101 - 0.129 0.452 2.405
ENSG00000143401 E025 1.1845453 0.5263662391 2.333419e-01 3.663767e-01 1 150236264 150236512 249 - 0.129 0.567 2.954