ENSG00000143398

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000349792 ENSG00000143398 HEK293_OSMI2_2hA HEK293_TMG_2hB PIP5K1A protein_coding protein_coding 78.74881 84.31528 83.45542 7.326935 1.086523 -0.01478662 32.42515 23.626795 38.2224551 2.9529636 0.3841558 0.6937634 0.41522917 0.28090000 0.45803333 0.17713333 4.103560e-04 7.081376e-06 FALSE TRUE
ENST00000409426 ENSG00000143398 HEK293_OSMI2_2hA HEK293_TMG_2hB PIP5K1A protein_coding protein_coding 78.74881 84.31528 83.45542 7.326935 1.086523 -0.01478662 19.90830 16.705359 23.6941391 0.8936663 0.7526051 0.5039646 0.25541250 0.19933333 0.28380000 0.08446667 7.081376e-06 7.081376e-06 FALSE TRUE
ENST00000489625 ENSG00000143398 HEK293_OSMI2_2hA HEK293_TMG_2hB PIP5K1A protein_coding retained_intron 78.74881 84.31528 83.45542 7.326935 1.086523 -0.01478662 11.15566 28.879881 0.4196222 5.6182619 0.2570139 -6.0713519 0.13602083 0.33883333 0.00510000 -0.33373333 6.666892e-05 7.081376e-06 FALSE FALSE
MSTRG.2209.8 ENSG00000143398 HEK293_OSMI2_2hA HEK293_TMG_2hB PIP5K1A protein_coding   78.74881 84.31528 83.45542 7.326935 1.086523 -0.01478662 3.97179 4.044324 5.0062011 0.2018218 0.2706785 0.3071338 0.05054583 0.04906667 0.05993333 0.01086667 5.144851e-01 7.081376e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000143398 E001 2.9078926 0.0101064615 2.269590e-01 3.587650e-01 1 151197949 151198117 169 + 0.654 0.502 -0.688
ENSG00000143398 E002 4.5811118 0.0043279835 5.994356e-01 7.208184e-01 1 151198551 151198551 1 + 0.754 0.728 -0.104
ENSG00000143398 E003 4.7262845 0.0036587847 4.877103e-01 6.253571e-01 1 151198552 151198552 1 + 0.776 0.728 -0.192
ENSG00000143398 E004 5.1294340 0.0036824772 7.658129e-01 8.484862e-01 1 151198553 151198553 1 + 0.776 0.784 0.031
ENSG00000143398 E005 23.8224881 0.0008172543 3.862070e-04 1.721547e-03 1 151198554 151198569 16 + 1.480 1.282 -0.689
ENSG00000143398 E006 70.1358302 0.0050870208 2.024161e-01 3.292440e-01 1 151198570 151198589 20 + 1.859 1.843 -0.055
ENSG00000143398 E007 347.7853270 0.0013673356 2.188639e-05 1.344328e-04 1 151198590 151198688 99 + 2.570 2.514 -0.187
ENSG00000143398 E008 359.0379850 0.0004228758 2.810524e-08 3.181438e-07 1 151198689 151198724 36 + 2.586 2.526 -0.199
ENSG00000143398 E009 860.7997908 0.0006814941 1.199022e-12 2.905435e-11 1 151198725 151199081 357 + 2.968 2.903 -0.219
ENSG00000143398 E010 9.7184230 0.0671081780 9.526582e-01 9.743414e-01 1 151199082 151199187 106 + 1.003 1.051 0.179
ENSG00000143398 E011 1.5281878 0.2591877249 9.718942e-01 9.864343e-01 1 151213480 151213516 37 + 0.393 0.438 0.244
ENSG00000143398 E012 2.5664290 0.1597801903 6.417290e-01 7.547032e-01 1 151213517 151213547 31 + 0.485 0.623 0.637
ENSG00000143398 E013 0.1515154 0.0442340226 5.352583e-01   1 151215962 151216000 39 + 0.111 0.000 -9.981
ENSG00000143398 E014 3.4142538 0.1970417529 3.300526e-01 4.736464e-01 1 151223880 151224138 259 + 0.483 0.746 1.164
ENSG00000143398 E015 2.4145610 0.1534481203 5.340735e-01 6.661835e-01 1 151224139 151224244 106 + 0.439 0.626 0.882
ENSG00000143398 E016 82.0361861 0.0003588034 8.484784e-02 1.671614e-01 1 151224245 151224247 3 + 1.927 1.917 -0.036
ENSG00000143398 E017 307.5381770 0.0002131518 1.534348e-08 1.826782e-07 1 151224248 151224279 32 + 2.522 2.461 -0.204
ENSG00000143398 E018 14.8242783 0.0029585875 8.251072e-01 8.898268e-01 1 151224371 151224406 36 + 1.185 1.219 0.121
ENSG00000143398 E019 0.8889184 0.0136099862 1.120109e-01 2.084964e-01 1 151227267 151227319 53 + 0.391 0.134 -2.013
ENSG00000143398 E020 394.7412656 0.0002495817 2.779535e-07 2.589499e-06 1 151227320 151227400 81 + 2.619 2.579 -0.135
ENSG00000143398 E021 539.6525384 0.0001511559 2.881858e-13 7.676594e-12 1 151231671 151231801 131 + 2.764 2.705 -0.196
ENSG00000143398 E022 251.1648579 0.0001959519 1.383275e-08 1.661640e-07 1 151232248 151232251 4 + 2.439 2.367 -0.242
ENSG00000143398 E023 554.1397907 0.0010201872 1.852269e-08 2.173740e-07 1 151232252 151232365 114 + 2.777 2.712 -0.214
ENSG00000143398 E024 612.0328974 0.0023291895 1.351435e-05 8.709529e-05 1 151232551 151232703 153 + 2.819 2.754 -0.217
ENSG00000143398 E025 1.0956150 0.3635880934 5.003576e-01 6.366187e-01 1 151233329 151233398 70 + 0.390 0.238 -0.996
ENSG00000143398 E026 0.9943357 0.0122639601 4.765518e-01 6.151679e-01 1 151233622 151233784 163 + 0.336 0.237 -0.688
ENSG00000143398 E027 737.5353003 0.0008511394 2.334142e-05 1.424968e-04 1 151234197 151234496 300 + 2.882 2.858 -0.081
ENSG00000143398 E028 325.7850816 0.0005265687 1.403181e-01 2.484610e-01 1 151236558 151236633 76 + 2.505 2.528 0.077
ENSG00000143398 E029 553.8337686 0.0001315905 4.442428e-04 1.944513e-03 1 151236634 151236763 130 + 2.746 2.749 0.009
ENSG00000143398 E030 482.5077051 0.0001161907 1.018769e-02 2.922719e-02 1 151238182 151238265 84 + 2.680 2.695 0.050
ENSG00000143398 E031 12.3280954 0.0020254911 1.610783e-08 1.910821e-07 1 151238266 151238605 340 + 1.313 0.783 -1.949
ENSG00000143398 E032 427.4966945 0.0001777446 6.851356e-02 1.409120e-01 1 151239130 151239178 49 + 2.622 2.647 0.082
ENSG00000143398 E033 526.2135729 0.0005432631 5.966719e-01 7.185802e-01 1 151239955 151240039 85 + 2.701 2.746 0.151
ENSG00000143398 E034 6.2118290 0.0027621253 9.337077e-03 2.712592e-02 1 151240040 151240291 252 + 0.977 0.698 -1.089
ENSG00000143398 E035 2.3646654 0.0063543734 9.183825e-01 9.524334e-01 1 151242112 151242122 11 + 0.523 0.548 0.117
ENSG00000143398 E036 658.8782130 0.0003336417 9.452015e-01 9.696111e-01 1 151242123 151242269 147 + 2.794 2.849 0.184
ENSG00000143398 E037 659.8960851 0.0001762844 1.008715e-01 1.917942e-01 1 151242438 151242567 130 + 2.782 2.863 0.271
ENSG00000143398 E038 479.6812809 0.0001368787 4.661874e-01 6.057546e-01 1 151246920 151246965 46 + 2.650 2.719 0.231
ENSG00000143398 E039 3655.5872318 0.0036798258 1.140478e-14 3.720043e-13 1 151247863 151249536 1674 + 3.436 3.664 0.759