ENSG00000143393

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000368872 ENSG00000143393 HEK293_OSMI2_2hA HEK293_TMG_2hB PI4KB protein_coding protein_coding 79.98229 128.8582 50.23084 3.341646 0.293464 -1.358964 4.820200 5.382564 4.131547 0.9912105 0.6747346 -0.3808018 0.06767500 0.04170000 0.08216667 0.04046667 8.408895e-02 2.147314e-36 FALSE TRUE
ENST00000368874 ENSG00000143393 HEK293_OSMI2_2hA HEK293_TMG_2hB PI4KB protein_coding protein_coding 79.98229 128.8582 50.23084 3.341646 0.293464 -1.358964 32.327824 48.049033 21.588294 2.9555912 0.8067463 -1.1538903 0.40889167 0.37276667 0.42966667 0.05690000 3.097167e-01 2.147314e-36 FALSE TRUE
ENST00000446339 ENSG00000143393 HEK293_OSMI2_2hA HEK293_TMG_2hB PI4KB protein_coding protein_coding 79.98229 128.8582 50.23084 3.341646 0.293464 -1.358964 4.072519 10.858336 0.000000 0.9139802 0.0000000 -10.0859153 0.04071250 0.08450000 0.00000000 -0.08450000 2.147314e-36 2.147314e-36   FALSE
ENST00000529142 ENSG00000143393 HEK293_OSMI2_2hA HEK293_TMG_2hB PI4KB protein_coding protein_coding 79.98229 128.8582 50.23084 3.341646 0.293464 -1.358964 15.487764 38.397192 3.970929 4.0567691 0.1760915 -3.2701994 0.16170417 0.29906667 0.07903333 -0.22003333 4.627461e-10 2.147314e-36 FALSE TRUE
MSTRG.2212.5 ENSG00000143393 HEK293_OSMI2_2hA HEK293_TMG_2hB PI4KB protein_coding   79.98229 128.8582 50.23084 3.341646 0.293464 -1.358964 8.340093 8.430199 6.971358 1.1950500 0.4035322 -0.2737693 0.11755417 0.06503333 0.13886667 0.07383333 3.413791e-04 2.147314e-36 FALSE TRUE
MSTRG.2212.6 ENSG00000143393 HEK293_OSMI2_2hA HEK293_TMG_2hB PI4KB protein_coding   79.98229 128.8582 50.23084 3.341646 0.293464 -1.358964 6.256857 8.103741 6.882454 2.7247912 1.1023266 -0.2353495 0.08572917 0.06210000 0.13723333 0.07513333 2.141781e-01 2.147314e-36 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000143393 E001 0.6568746 2.085935e-02 9.455038e-01 9.698095e-01 1 151291797 151291803 7 - 0.186 0.203 0.160
ENSG00000143393 E002 62.0169069 2.331259e-02 2.511679e-01 3.873293e-01 1 151291804 151291936 133 - 1.651 1.753 0.345
ENSG00000143393 E003 113.9298984 6.188495e-03 2.110324e-02 5.381612e-02 1 151291937 151292132 196 - 1.888 2.018 0.438
ENSG00000143393 E004 1106.5023856 3.848284e-03 1.875859e-08 2.198972e-07 1 151292133 151292478 346 - 2.827 3.010 0.609
ENSG00000143393 E005 1068.5561537 5.497513e-03 4.876822e-05 2.755359e-04 1 151292479 151292601 123 - 2.835 2.990 0.516
ENSG00000143393 E006 591.4396208 3.631782e-03 2.122147e-07 2.024342e-06 1 151292602 151292622 21 - 2.556 2.739 0.606
ENSG00000143393 E007 1699.6681408 1.765426e-03 7.208792e-10 1.098965e-08 1 151292623 151292954 332 - 3.052 3.188 0.453
ENSG00000143393 E008 615.6192421 1.034472e-04 4.744097e-17 2.119705e-15 1 151292955 151293033 79 - 2.599 2.748 0.498
ENSG00000143393 E009 12.6553738 1.481845e-03 4.588594e-01 5.991023e-01 1 151293400 151293462 63 - 1.123 1.047 -0.275
ENSG00000143393 E010 26.0820330 7.602371e-04 5.176755e-03 1.640907e-02 1 151293619 151294017 399 - 1.504 1.303 -0.696
ENSG00000143393 E011 396.3610328 1.287671e-04 2.138015e-06 1.652350e-05 1 151294018 151294048 31 - 2.446 2.549 0.344
ENSG00000143393 E012 764.5006324 1.700357e-04 1.930262e-04 9.340304e-04 1 151294049 151294138 90 - 2.764 2.824 0.200
ENSG00000143393 E013 877.0082566 1.329462e-03 9.758331e-02 1.867964e-01 1 151294409 151294541 133 - 2.842 2.880 0.128
ENSG00000143393 E014 4.6769906 4.080330e-03 1.729829e-02 4.560092e-02 1 151298425 151298807 383 - 0.927 0.600 -1.325
ENSG00000143393 E015 1091.2217165 1.132464e-04 1.896590e-03 6.903570e-03 1 151298808 151299073 266 - 2.933 2.975 0.137
ENSG00000143393 E016 733.1411546 7.085992e-04 8.613088e-01 9.145305e-01 1 151301844 151301967 124 - 2.794 2.792 -0.007
ENSG00000143393 E017 451.9684495 3.104156e-03 2.314755e-01 3.642309e-01 1 151302194 151302247 54 - 2.611 2.574 -0.124
ENSG00000143393 E018 510.5488818 1.818864e-03 1.983932e-01 3.241987e-01 1 151302248 151302298 51 - 2.660 2.627 -0.109
ENSG00000143393 E019 2.6152674 5.618671e-03 3.718134e-01 5.162933e-01 1 151303354 151303540 187 - 0.623 0.475 -0.688
ENSG00000143393 E020 673.3860459 4.713884e-04 9.314571e-03 2.706842e-02 1 151303541 151303650 110 - 2.790 2.744 -0.154
ENSG00000143393 E021 743.5853777 9.101973e-05 1.587706e-06 1.262058e-05 1 151306136 151306263 128 - 2.852 2.782 -0.234
ENSG00000143393 E022 656.5221216 1.357152e-04 1.525895e-09 2.186824e-08 1 151306264 151306363 100 - 2.816 2.721 -0.317
ENSG00000143393 E023 3.7621205 8.842620e-02 9.067537e-01 9.447761e-01 1 151306364 151306433 70 - 0.623 0.606 -0.073
ENSG00000143393 E024 916.5387141 3.324467e-04 7.010553e-09 8.894510e-08 1 151307574 151307801 228 - 2.954 2.867 -0.289
ENSG00000143393 E025 18.2056653 1.035561e-03 5.150660e-02 1.118279e-01 1 151310211 151310255 45 - 1.338 1.173 -0.580
ENSG00000143393 E026 554.7197814 2.614746e-03 3.165341e-05 1.872839e-04 1 151315573 151315639 67 - 2.762 2.641 -0.401
ENSG00000143393 E027 455.3750585 2.428039e-03 5.235923e-06 3.708565e-05 1 151315640 151315672 33 - 2.685 2.552 -0.444
ENSG00000143393 E028 1853.7173932 3.549164e-03 2.426032e-09 3.347204e-08 1 151315673 151316509 837 - 3.314 3.153 -0.533
ENSG00000143393 E029 126.3111064 6.293786e-03 2.158389e-06 1.666329e-05 1 151324745 151324917 173 - 2.201 1.962 -0.798
ENSG00000143393 E030 172.7832557 1.090155e-02 1.558795e-04 7.732830e-04 1 151326172 151326373 202 - 2.322 2.107 -0.720
ENSG00000143393 E031 364.0314063 6.727097e-03 1.553224e-03 5.808745e-03 1 151327271 151327715 445 - 2.590 2.454 -0.453