ENSG00000143379

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000271640 ENSG00000143379 HEK293_OSMI2_2hA HEK293_TMG_2hB SETDB1 protein_coding protein_coding 33.11852 28.70376 38.04995 2.777269 0.2742163 0.4065317 2.968977 2.5798568 1.6289133 1.0778915 0.8519666 -0.6601328 0.09153333 0.092233333 0.0427000 -0.049533333 7.492406e-01 1.651174e-21 FALSE TRUE
ENST00000368962 ENSG00000143379 HEK293_OSMI2_2hA HEK293_TMG_2hB SETDB1 protein_coding protein_coding 33.11852 28.70376 38.04995 2.777269 0.2742163 0.4065317 3.615942 2.5498022 3.5278481 0.6877993 0.3169329 0.4668397 0.10577083 0.085700000 0.0927000 0.007000000 9.024571e-01 1.651174e-21 FALSE TRUE
ENST00000497314 ENSG00000143379 HEK293_OSMI2_2hA HEK293_TMG_2hB SETDB1 protein_coding retained_intron 33.11852 28.70376 38.04995 2.777269 0.2742163 0.4065317 1.856666 1.1628379 1.6567566 0.1999414 0.2958223 0.5070399 0.05688333 0.040166667 0.0435000 0.003333333 9.476065e-01 1.651174e-21 TRUE TRUE
ENST00000525956 ENSG00000143379 HEK293_OSMI2_2hA HEK293_TMG_2hB SETDB1 protein_coding protein_coding 33.11852 28.70376 38.04995 2.777269 0.2742163 0.4065317 2.157366 0.2838327 4.7848439 0.2838327 0.5464060 4.0284171 0.05879167 0.009266667 0.1256333 0.116366667 2.757129e-02 1.651174e-21 FALSE FALSE
ENST00000528749 ENSG00000143379 HEK293_OSMI2_2hA HEK293_TMG_2hB SETDB1 protein_coding retained_intron 33.11852 28.70376 38.04995 2.777269 0.2742163 0.4065317 1.759017 0.6437648 2.0276942 0.2310094 0.4735356 1.6400940 0.05376250 0.023966667 0.0531000 0.029133333 3.304301e-01 1.651174e-21   FALSE
ENST00000533529 ENSG00000143379 HEK293_OSMI2_2hA HEK293_TMG_2hB SETDB1 protein_coding retained_intron 33.11852 28.70376 38.04995 2.777269 0.2742163 0.4065317 1.593710 2.9805703 0.9181653 0.8473980 0.1970963 -1.6879669 0.05107500 0.100033333 0.0242000 -0.075833333 9.196094e-04 1.651174e-21 FALSE FALSE
ENST00000692314 ENSG00000143379 HEK293_OSMI2_2hA HEK293_TMG_2hB SETDB1 protein_coding protein_coding 33.11852 28.70376 38.04995 2.777269 0.2742163 0.4065317 2.347142 4.5467884 0.0000000 0.5219867 0.0000000 -8.8318736 0.08037917 0.165233333 0.0000000 -0.165233333 1.651174e-21 1.651174e-21 FALSE TRUE
ENST00000692827 ENSG00000143379 HEK293_OSMI2_2hA HEK293_TMG_2hB SETDB1 protein_coding protein_coding 33.11852 28.70376 38.04995 2.777269 0.2742163 0.4065317 10.541723 9.4428865 14.6809542 0.8308405 0.6953514 0.6361013 0.31549167 0.330800000 0.3860333 0.055233333 3.988472e-01 1.651174e-21 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000143379 E001 4.593939 0.0286366564 2.011542e-01 3.276309e-01 1 150926263 150926304 42 + 0.843 0.654 -0.766
ENSG00000143379 E002 8.559769 0.0195214046 4.164071e-02 9.407671e-02 1 150926305 150926329 25 + 1.100 0.850 -0.932
ENSG00000143379 E003 12.940161 0.0015655372 1.136863e-02 3.204517e-02 1 150926330 150926338 9 + 1.252 1.025 -0.815
ENSG00000143379 E004 13.882070 0.0030060163 9.072832e-03 2.646186e-02 1 150926339 150926344 6 + 1.283 1.051 -0.830
ENSG00000143379 E005 14.107782 0.0047057911 1.518778e-02 4.091346e-02 1 150926345 150926348 4 + 1.283 1.063 -0.785
ENSG00000143379 E006 1.663984 0.0091028628 1.802965e-01 3.015426e-01 1 150926349 150926362 14 + 0.521 0.292 -1.270
ENSG00000143379 E007 16.464481 0.0011810726 9.303657e-03 2.704127e-02 1 150926363 150926394 32 + 1.340 1.130 -0.741
ENSG00000143379 E008 23.472729 0.0008216141 4.557683e-03 1.470336e-02 1 150926395 150926411 17 + 1.484 1.291 -0.668
ENSG00000143379 E009 38.942868 0.0005194778 3.450583e-02 8.072596e-02 1 150926412 150926423 12 + 1.660 1.551 -0.372
ENSG00000143379 E010 79.381890 0.0003545388 1.679348e-08 1.985320e-07 1 150926424 150926463 40 + 2.011 1.795 -0.727
ENSG00000143379 E011 71.172417 0.0003625298 2.364878e-08 2.717572e-07 1 150926464 150926480 17 + 1.967 1.741 -0.763
ENSG00000143379 E012 66.816700 0.0003712212 3.339795e-07 3.059990e-06 1 150926481 150926486 6 + 1.935 1.723 -0.716
ENSG00000143379 E013 80.948953 0.0003771531 7.966220e-11 1.429550e-09 1 150926487 150926517 31 + 2.033 1.784 -0.839
ENSG00000143379 E014 11.538166 0.0014933115 6.475536e-02 1.346443e-01 1 150926518 150926531 14 + 1.183 1.012 -0.618
ENSG00000143379 E015 11.838905 0.0016158974 1.104887e-01 2.062445e-01 1 150926532 150926544 13 + 1.183 1.038 -0.522
ENSG00000143379 E016 4.302183 0.0873905657 2.522946e-01 3.886210e-01 1 150926640 150926808 169 + 0.821 0.624 -0.811
ENSG00000143379 E017 192.952713 0.0010005941 6.583991e-12 1.412270e-10 1 150927704 150927841 138 + 2.384 2.192 -0.640
ENSG00000143379 E018 209.968096 0.0029810343 1.151237e-06 9.436997e-06 1 150927842 150927974 133 + 2.408 2.244 -0.546
ENSG00000143379 E019 2.436865 0.0061151264 1.069655e-04 5.541689e-04 1 150927975 150928229 255 + 0.776 0.121 -3.954
ENSG00000143379 E020 118.412694 0.0003657968 1.337936e-06 1.081302e-05 1 150929967 150929997 31 + 2.154 2.003 -0.506
ENSG00000143379 E021 180.002872 0.0028527228 6.662514e-04 2.775088e-03 1 150929998 150930118 121 + 2.318 2.201 -0.391
ENSG00000143379 E022 19.449915 0.0080168555 1.619651e-06 1.285240e-05 1 150930119 150930456 338 + 1.493 1.074 -1.473
ENSG00000143379 E023 102.934510 0.0063398112 6.593107e-02 1.365852e-01 1 150939940 150939974 35 + 2.063 1.976 -0.291
ENSG00000143379 E024 136.664132 0.0044635641 8.211887e-02 1.628665e-01 1 150941329 150941428 100 + 2.177 2.107 -0.232
ENSG00000143379 E025 175.465880 0.0005778192 2.461052e-03 8.647184e-03 1 150942563 150942688 126 + 2.290 2.213 -0.259
ENSG00000143379 E026 226.940938 0.0018352282 1.558603e-01 2.695939e-01 1 150942852 150943053 202 + 2.378 2.343 -0.117
ENSG00000143379 E027 138.818266 0.0003181146 4.549650e-01 5.955390e-01 1 150943920 150943993 74 + 2.156 2.142 -0.048
ENSG00000143379 E028 225.707441 0.0012649718 1.557593e-01 2.694459e-01 1 150944918 150945108 191 + 2.374 2.342 -0.106
ENSG00000143379 E029 23.046204 0.0221298849 3.791341e-02 8.718241e-02 1 150945109 150945320 212 + 1.244 1.478 0.810
ENSG00000143379 E030 122.682211 0.0002392749 1.649934e-02 4.384297e-02 1 150946886 150947012 127 + 2.130 2.061 -0.229
ENSG00000143379 E031 126.499789 0.0002479568 4.925325e-01 6.296934e-01 1 150949122 150949278 157 + 2.112 2.098 -0.046
ENSG00000143379 E032 37.632875 0.0091802721 6.799705e-01 7.840075e-01 1 150949367 150949369 3 + 1.562 1.594 0.112
ENSG00000143379 E033 67.963060 0.0079621785 6.332791e-01 7.480069e-01 1 150949370 150949403 34 + 1.817 1.848 0.105
ENSG00000143379 E034 113.156030 0.0033660579 7.077064e-01 8.055229e-01 1 150949404 150949525 122 + 2.044 2.064 0.068
ENSG00000143379 E035 329.062838 0.0046249345 9.956035e-01 1.000000e+00 1 150950458 150951090 633 + 2.513 2.518 0.017
ENSG00000143379 E036 155.818641 0.0002226768 2.444361e-01 3.793939e-01 1 150951365 150951481 117 + 2.172 2.213 0.138
ENSG00000143379 E037 195.290320 0.0002604918 1.750354e-02 4.605099e-02 1 150959178 150959347 170 + 2.251 2.320 0.231
ENSG00000143379 E038 10.265359 0.0016998571 6.704983e-04 2.790569e-03 1 150960184 150960562 379 + 1.210 0.869 -1.252
ENSG00000143379 E039 190.286584 0.0014060603 2.583861e-03 9.015982e-03 1 150960563 150960701 139 + 2.221 2.320 0.330
ENSG00000143379 E040 360.248149 0.0002763937 1.244986e-05 8.093433e-05 1 150960702 150961191 490 + 2.502 2.595 0.311
ENSG00000143379 E041 21.156599 0.0011293825 1.568994e-07 1.534703e-06 1 150961317 150962127 811 + 1.520 1.129 -1.365
ENSG00000143379 E042 12.394903 0.0235209056 7.479564e-01 8.353580e-01 1 150962128 150962129 2 + 1.144 1.116 -0.100
ENSG00000143379 E043 98.737871 0.0019784566 1.412455e-02 3.850925e-02 1 150962130 150962158 29 + 1.935 2.044 0.366
ENSG00000143379 E044 216.294648 0.0002043543 2.203837e-03 7.854581e-03 1 150962587 150962719 133 + 2.288 2.371 0.276
ENSG00000143379 E045 15.126123 0.0390798370 4.947856e-03 1.578626e-02 1 150962720 150962973 254 + 1.366 1.011 -1.265
ENSG00000143379 E046 286.305940 0.0002238392 1.971725e-06 1.535864e-05 1 150962974 150963139 166 + 2.393 2.503 0.368
ENSG00000143379 E047 31.214404 0.0007102676 1.176846e-03 4.562943e-03 1 150963140 150963529 390 + 1.606 1.414 -0.660
ENSG00000143379 E048 345.157381 0.0003000469 2.249263e-14 7.023506e-13 1 150963530 150963741 212 + 2.442 2.605 0.544
ENSG00000143379 E049 8.400139 0.0065840872 1.002271e-01 1.908256e-01 1 150963742 150963851 110 + 0.863 1.061 0.742
ENSG00000143379 E050 227.047392 0.0034451715 9.685365e-07 8.057895e-06 1 150963995 150964083 89 + 2.244 2.429 0.616
ENSG00000143379 E051 122.414230 0.0002819026 1.626639e-08 1.928181e-07 1 150964247 150964249 3 + 1.972 2.166 0.650
ENSG00000143379 E052 396.223329 0.0037875209 2.630724e-10 4.314629e-09 1 150964250 150964779 530 + 2.462 2.683 0.737