ENSG00000143376

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000368838 ENSG00000143376 HEK293_OSMI2_2hA HEK293_TMG_2hB SNX27 protein_coding protein_coding 11.07222 10.5942 10.31165 0.6077062 0.03404777 -0.03896143 1.4407359 2.45575077 0.549089 0.29773018 0.3486907 -2.1408771 0.12691250 0.232400000 0.05336667 -0.17903333 0.1999129736 6.872885e-07 FALSE TRUE
ENST00000368843 ENSG00000143376 HEK293_OSMI2_2hA HEK293_TMG_2hB SNX27 protein_coding protein_coding 11.07222 10.5942 10.31165 0.6077062 0.03404777 -0.03896143 0.4555346 0.03390244 1.003722 0.03390244 0.2928294 4.5292178 0.04276667 0.003566667 0.09736667 0.09380000 0.0002242702 6.872885e-07 FALSE TRUE
ENST00000458013 ENSG00000143376 HEK293_OSMI2_2hA HEK293_TMG_2hB SNX27 protein_coding protein_coding 11.07222 10.5942 10.31165 0.6077062 0.03404777 -0.03896143 6.8273691 7.30236468 6.125478 0.55240175 0.2941998 -0.2531622 0.61584583 0.687966667 0.59390000 -0.09406667 0.1707375288 6.872885e-07 FALSE TRUE
ENST00000642349 ENSG00000143376 HEK293_OSMI2_2hA HEK293_TMG_2hB SNX27 protein_coding nonsense_mediated_decay 11.07222 10.5942 10.31165 0.6077062 0.03404777 -0.03896143 1.0958290 0.11733484 1.161536 0.06308735 0.2875657 3.2017022 0.10070417 0.010466667 0.11246667 0.10200000 0.0003374118 6.872885e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

No results under this category.

Splicing

All exons whithin this gene region are shown and numbering below.

No results under this category.

Transcripts

All isoforms whithin this gene region are shown below.

No results under this category.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000143376 E001 0.7427016 0.0156764037 1.644005e-02 4.370210e-02 1 151612006 151612028 23 +      
ENSG00000143376 E002 2.1528619 0.0179931029 6.805742e-04 2.828031e-03 1 151612029 151612049 21 +      
ENSG00000143376 E003 3.1085896 0.0050582144 1.369024e-04 6.898358e-04 1 151612050 151612063 14 +      
ENSG00000143376 E004 6.6002961 0.0024210899 6.996046e-07 6.007796e-06 1 151612064 151612188 125 +      
ENSG00000143376 E005 13.5369193 0.0013230705 2.584104e-11 5.030480e-10 1 151612189 151612336 148 +      
ENSG00000143376 E006 15.2596783 0.0319912587 1.904854e-04 9.232687e-04 1 151612337 151612381 45 +      
ENSG00000143376 E007 14.4294416 0.0219583284 1.305133e-04 6.610527e-04 1 151612382 151612393 12 +      
ENSG00000143376 E008 22.3486692 0.0153750584 7.072161e-06 4.864923e-05 1 151612394 151612480 87 +      
ENSG00000143376 E009 13.7464161 0.0191846646 1.305728e-04 6.612832e-04 1 151612481 151612485 5 +      
ENSG00000143376 E010 18.3434382 0.0181368843 3.621874e-05 2.109358e-04 1 151612486 151612512 27 +      
ENSG00000143376 E011 0.7384326 0.0479995898 3.260689e-01 4.695050e-01 1 151613926 151614466 541 +      
ENSG00000143376 E012 0.2966881 0.0290785164 1.987995e-01   1 151638856 151638887 32 +      
ENSG00000143376 E013 15.2582187 0.0073233594 2.870992e-05 1.715776e-04 1 151638888 151638892 5 +      
ENSG00000143376 E014 31.4330328 0.0007638965 1.059887e-12 2.589867e-11 1 151638893 151638979 87 +      
ENSG00000143376 E015 39.3573564 0.0177359438 5.865715e-07 5.120931e-06 1 151638980 151639119 140 +      
ENSG00000143376 E016 20.6958164 0.0025445712 7.946369e-04 3.240589e-03 1 151658235 151658242 8 +      
ENSG00000143376 E017 50.3013797 0.0108275311 1.020811e-06 8.450123e-06 1 151658243 151658368 126 +      
ENSG00000143376 E018 43.0911634 0.0006093156 3.848748e-10 6.156144e-09 1 151658369 151658427 59 +      
ENSG00000143376 E019 0.4407149 0.0212456828 5.590592e-01 6.872231e-01 1 151659584 151660188 605 +      
ENSG00000143376 E020 0.0000000       1 151660384 151660797 414 +      
ENSG00000143376 E021 45.6777380 0.0112884959 1.096092e-04 5.661931e-04 1 151660798 151660862 65 +      
ENSG00000143376 E022 0.0000000       1 151660863 151661536 674 +      
ENSG00000143376 E023 57.0655212 0.0024806770 4.740799e-12 1.040345e-10 1 151662166 151662270 105 +      
ENSG00000143376 E024 0.2214452 0.0403935722 4.883346e-01   1 151662271 151662744 474 +      
ENSG00000143376 E025 47.9346298 0.0005034890 1.873463e-14 5.924251e-13 1 151665933 151666011 79 +      
ENSG00000143376 E026 0.8418013 0.3126400722 8.149065e-01 8.827203e-01 1 151666012 151667231 1220 +      
ENSG00000143376 E027 68.7076486 0.0004548375 1.420524e-17 6.840721e-16 1 151668472 151668635 164 +      
ENSG00000143376 E028 1.7649465 0.0112100235 3.892441e-01 5.333626e-01 1 151669141 151669363 223 +      
ENSG00000143376 E029 0.1515154 0.0427742296 4.864796e-01   1 151675856 151680453 4598 +      
ENSG00000143376 E030 48.1713904 0.0033260821 9.802145e-14 2.789944e-12 1 151683356 151683445 90 +      
ENSG00000143376 E031 0.1472490 0.0426292636 4.869110e-01   1 151685346 151685509 164 +      
ENSG00000143376 E032 66.9562951 0.0143869415 1.092094e-07 1.101613e-06 1 151692435 151692584 150 +      
ENSG00000143376 E033 56.7380575 0.0092824558 1.635249e-06 1.296368e-05 1 151692911 151693039 129 +      
ENSG00000143376 E034 0.1451727 0.0429310105 4.873580e-01   1 151693040 151693423 384 +      
ENSG00000143376 E035 30.7643889 0.0058653206 9.541148e-04 3.801910e-03 1 151693424 151693483 60 +      
ENSG00000143376 E036 1.5134140 0.0090397782 1.958423e-01 3.210270e-01 1 151693484 151693543 60 +      
ENSG00000143376 E037 1.6522440 0.0087901194 1.233828e-01 2.247743e-01 1 151693544 151693592 49 +      
ENSG00000143376 E038 54.4631708 0.0008381292 8.031640e-06 5.452093e-05 1 151693593 151694369 777 +      
ENSG00000143376 E039 1451.1564236 0.0138444149 7.211196e-21 5.128151e-19 1 151694370 151699091 4722 +