ENSG00000143375

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000271636 ENSG00000143375 HEK293_OSMI2_2hA HEK293_TMG_2hB CGN protein_coding protein_coding 9.500203 9.843862 6.931455 0.2098774 0.2742333 -0.5054511 7.478069 7.237404 6.0590544 0.4315373 0.02011350 -0.2559926 0.7918750 0.7344333 0.87680000 0.1423667 0.06913722 0.01226977 FALSE TRUE
ENST00000467998 ENSG00000143375 HEK293_OSMI2_2hA HEK293_TMG_2hB CGN protein_coding retained_intron 9.500203 9.843862 6.931455 0.2098774 0.2742333 -0.5054511 1.276065 2.176456 0.4721603 0.4840902 0.08170592 -2.1810091 0.1314167 0.2231333 0.06743333 -0.1557000 0.01226977 0.01226977 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000143375 E001 0.0000000       1 151510510 151510549 40 +      
ENSG00000143375 E002 0.3634088 0.3678698892 4.179149e-01   1 151510936 151511000 65 + 0.000 0.190 9.306
ENSG00000143375 E003 20.7059403 0.0009458631 9.362000e-05 4.920114e-04 1 151511387 151511515 129 + 1.474 1.188 -0.997
ENSG00000143375 E004 0.0000000       1 151515495 151515616 122 +      
ENSG00000143375 E005 136.8185123 0.0076016738 1.005716e-06 8.337926e-06 1 151518506 151519369 864 + 2.253 2.021 -0.777
ENSG00000143375 E006 27.3700404 0.0007490715 5.677415e-04 2.412943e-03 1 151519370 151519392 23 + 1.561 1.342 -0.756
ENSG00000143375 E007 45.6338533 0.0005749520 4.105139e-04 1.814527e-03 1 151520166 151520266 101 + 1.753 1.577 -0.598
ENSG00000143375 E008 39.6445470 0.0009112073 4.485778e-01 5.898567e-01 1 151520414 151520483 70 + 1.614 1.577 -0.125
ENSG00000143375 E009 30.5331920 0.0149888819 6.205006e-01 7.376597e-01 1 151520596 151520619 24 + 1.507 1.468 -0.132
ENSG00000143375 E010 46.5964846 0.0176496238 6.189593e-01 7.364711e-01 1 151520620 151520691 72 + 1.685 1.646 -0.131
ENSG00000143375 E011 60.2845935 0.0004580290 9.191561e-01 9.529333e-01 1 151523434 151523561 128 + 1.771 1.773 0.007
ENSG00000143375 E012 56.2106945 0.0004551762 4.480162e-01 5.893520e-01 1 151524226 151524358 133 + 1.756 1.727 -0.100
ENSG00000143375 E013 78.3145507 0.0017083676 3.013453e-01 4.431341e-01 1 151524674 151524886 213 + 1.905 1.866 -0.130
ENSG00000143375 E014 0.9169173 0.0157487672 2.081406e-01 3.362407e-01 1 151525594 151525641 48 + 0.408 0.189 -1.516
ENSG00000143375 E015 68.9713731 0.0003651681 7.041525e-02 1.440429e-01 1 151525642 151525790 149 + 1.870 1.800 -0.237
ENSG00000143375 E016 63.2737750 0.0004878058 1.735450e-01 2.927860e-01 1 151526975 151527107 133 + 1.744 1.813 0.232
ENSG00000143375 E017 72.0293545 0.0005848108 7.834842e-01 8.610504e-01 1 151529350 151529559 210 + 1.834 1.853 0.062
ENSG00000143375 E018 71.7274625 0.0004123695 9.554046e-01 9.760175e-01 1 151529909 151530115 207 + 1.842 1.851 0.030
ENSG00000143375 E019 80.8453240 0.0004290716 2.843106e-01 4.245398e-01 1 151530489 151530746 258 + 1.863 1.913 0.167
ENSG00000143375 E020 56.3849444 0.0004629083 9.588475e-01 9.782159e-01 1 151532402 151532572 171 + 1.735 1.744 0.030
ENSG00000143375 E021 58.4595610 0.0004215531 2.439804e-01 3.788760e-01 1 151533975 151534136 162 + 1.719 1.781 0.208
ENSG00000143375 E022 4.4544919 0.0064747515 7.999151e-04 3.259378e-03 1 151534140 151535041 902 + 0.962 0.502 -1.909
ENSG00000143375 E023 54.1391039 0.0004213896 9.606474e-01 9.792188e-01 1 151535042 151535131 90 + 1.722 1.726 0.014
ENSG00000143375 E024 55.0728779 0.0004292653 3.243091e-01 4.676636e-01 1 151535600 151535683 84 + 1.696 1.750 0.184
ENSG00000143375 E025 66.8250779 0.0005022741 1.294124e-01 2.333516e-01 1 151535780 151535877 98 + 1.765 1.839 0.251
ENSG00000143375 E026 41.2151355 0.0066053778 4.122968e-01 5.558643e-01 1 151535878 151535898 21 + 1.571 1.632 0.209
ENSG00000143375 E027 5.7402106 0.0047120888 4.746598e-01 6.134646e-01 1 151535899 151536236 338 + 0.859 0.771 -0.344
ENSG00000143375 E028 75.7392073 0.0135181292 4.682817e-01 6.077047e-01 1 151536237 151536345 109 + 1.835 1.888 0.177
ENSG00000143375 E029 89.7284155 0.0029632171 1.509324e-01 2.629353e-01 1 151536730 151536893 164 + 1.897 1.970 0.245
ENSG00000143375 E030 387.8824851 0.0034879859 1.768781e-05 1.110195e-04 1 151537205 151538692 1488 + 2.486 2.618 0.441