ENSG00000143373

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000324048 ENSG00000143373 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF687 protein_coding protein_coding 20.53875 27.37887 15.23366 2.464527 0.9540453 -0.8453807 1.1071094 1.3511706 1.072240 0.22907157 0.19953202 -0.3308271 0.05620833 0.04860000 0.07050000 0.02190000 4.257471e-01 2.213037e-10 FALSE TRUE
ENST00000336715 ENSG00000143373 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF687 protein_coding protein_coding 20.53875 27.37887 15.23366 2.464527 0.9540453 -0.8453807 10.4359643 17.0764531 5.364331 1.95122363 0.48301406 -1.6686960 0.48023750 0.62076667 0.35183333 -0.26893333 2.213037e-10 2.213037e-10 FALSE TRUE
ENST00000443959 ENSG00000143373 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF687 protein_coding protein_coding 20.53875 27.37887 15.23366 2.464527 0.9540453 -0.8453807 2.9072902 1.0871903 3.331907 1.08719030 0.43069414 1.6068580 0.16013750 0.03526667 0.21860000 0.18333333 7.008109e-02 2.213037e-10 FALSE TRUE
ENST00000459919 ENSG00000143373 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF687 protein_coding retained_intron 20.53875 27.37887 15.23366 2.464527 0.9540453 -0.8453807 0.8868293 0.7495774 1.578728 0.06750987 0.71610704 1.0646033 0.04618750 0.02740000 0.09886667 0.07146667 6.100834e-02 2.213037e-10 FALSE TRUE
MSTRG.2211.1 ENSG00000143373 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF687 protein_coding   20.53875 27.37887 15.23366 2.464527 0.9540453 -0.8453807 2.1852073 2.7579206 1.698612 0.04094103 0.05473075 -0.6959775 0.10674583 0.10230000 0.11280000 0.01050000 8.476861e-01 2.213037e-10 FALSE TRUE
MSTRG.2211.2 ENSG00000143373 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF687 protein_coding   20.53875 27.37887 15.23366 2.464527 0.9540453 -0.8453807 0.3012936 1.7751270 0.000000 0.94883391 0.00000000 -7.4798829 0.01214167 0.06840000 0.00000000 -0.06840000 2.204266e-01 2.213037e-10 FALSE TRUE
MSTRG.2211.4 ENSG00000143373 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF687 protein_coding   20.53875 27.37887 15.23366 2.464527 0.9540453 -0.8453807 2.4766406 2.4804128 2.014544 0.13722301 0.22591748 -0.2987878 0.12552917 0.09320000 0.13503333 0.04183333 4.649241e-01 2.213037e-10 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000143373 E001 21.4538742 0.0009630996 9.871054e-04 3.914760e-03 1 151281454 151281617 164 + 1.465 1.203 -0.914
ENSG00000143373 E002 33.0651457 0.0006545874 2.999991e-04 1.379531e-03 1 151281618 151281708 91 + 1.628 1.390 -0.818
ENSG00000143373 E003 35.8871535 0.0010533421 3.661114e-03 1.218530e-02 1 151281709 151282079 371 + 1.628 1.437 -0.655
ENSG00000143373 E004 6.8850546 0.0024848143 2.831744e-02 6.863802e-02 1 151282195 151282282 88 + 1.024 0.747 -1.061
ENSG00000143373 E005 7.5004793 0.0078476353 1.302837e-02 3.597887e-02 1 151282283 151282287 5 + 1.085 0.776 -1.166
ENSG00000143373 E006 12.7886241 0.0329711307 4.893011e-02 1.072567e-01 1 151282288 151282298 11 + 1.256 1.004 -0.907
ENSG00000143373 E007 17.2829811 0.0144780729 6.541984e-04 2.730949e-03 1 151282299 151282311 13 + 1.432 1.090 -1.204
ENSG00000143373 E008 61.4185635 0.0003897440 5.181702e-09 6.741693e-08 1 151282312 151282395 84 + 1.921 1.640 -0.950
ENSG00000143373 E009 36.4029292 0.0159153857 2.681887e-04 1.250278e-03 1 151285206 151286074 869 + 1.716 1.402 -1.071
ENSG00000143373 E010 853.0841176 0.0016223310 6.348838e-11 1.156619e-09 1 151286275 151287483 1209 + 2.959 2.823 -0.452
ENSG00000143373 E011 521.6873636 0.0004536045 3.124183e-01 4.549569e-01 1 151287484 151288190 707 + 2.663 2.637 -0.086
ENSG00000143373 E012 224.1685570 0.0002004488 6.006793e-02 1.267155e-01 1 151288191 151288406 216 + 2.244 2.288 0.147
ENSG00000143373 E013 226.4913663 0.0034382375 5.300381e-01 6.627293e-01 1 151288528 151288706 179 + 2.310 2.279 -0.102
ENSG00000143373 E014 292.4904875 0.0002973430 3.412408e-03 1.147384e-02 1 151289095 151289271 177 + 2.452 2.376 -0.255
ENSG00000143373 E015 8.3386013 0.0953942104 6.709825e-02 1.385366e-01 1 151289272 151289377 106 + 1.137 0.789 -1.304
ENSG00000143373 E016 338.3684660 0.0001429781 3.212067e-01 4.644454e-01 1 151289378 151289540 163 + 2.478 2.449 -0.098
ENSG00000143373 E017 502.7779772 0.0001208572 1.975873e-02 5.097549e-02 1 151289678 151290007 330 + 2.602 2.636 0.114
ENSG00000143373 E018 296.4928253 0.0001765991 3.227164e-04 1.471707e-03 1 151290122 151290234 113 + 2.337 2.417 0.265
ENSG00000143373 E019 1.8036697 0.4420807930 4.724336e-01 6.114885e-01 1 151290371 151290431 61 + 0.562 0.361 -1.031
ENSG00000143373 E020 141.5477318 0.0004314980 2.623765e-02 6.443249e-02 1 151290432 151290450 19 + 2.026 2.098 0.239
ENSG00000143373 E021 262.1698187 0.0002239445 1.281638e-06 1.040151e-05 1 151290451 151290573 123 + 2.252 2.372 0.401
ENSG00000143373 E022 2.6381712 0.0167374951 6.958978e-02 1.426732e-01 1 151290695 151290714 20 + 0.720 0.414 -1.413
ENSG00000143373 E023 113.6070247 0.0002987464 2.279201e-03 8.087883e-03 1 151290715 151290721 7 + 1.892 2.007 0.383
ENSG00000143373 E024 929.0608747 0.0009944448 1.163014e-17 5.656726e-16 1 151290722 151293235 2514 + 2.774 2.928 0.511
ENSG00000143373 E025 0.6599951 0.0193448783 2.284071e-01 3.605150e-01 1 151293370 151293463 94 + 0.001 0.254 8.946