ENSG00000143363

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000271620 ENSG00000143363 HEK293_OSMI2_2hA HEK293_TMG_2hB PRUNE1 protein_coding protein_coding 26.28255 30.68277 22.34198 1.855324 0.07945982 -0.4574962 9.3090978 7.2735860 9.373340 0.1696846 0.2527198 0.36545265 0.36150000 0.2390000 0.41963333 0.18063333 1.536918e-06 2.228017e-21 FALSE TRUE
ENST00000368934 ENSG00000143363 HEK293_OSMI2_2hA HEK293_TMG_2hB PRUNE1 protein_coding protein_coding 26.28255 30.68277 22.34198 1.855324 0.07945982 -0.4574962 2.1653898 6.5865487 0.000000 1.3473414 0.0000000 -9.36556759 0.07299167 0.2144667 0.00000000 -0.21446667 2.228017e-21 2.228017e-21 FALSE TRUE
ENST00000368936 ENSG00000143363 HEK293_OSMI2_2hA HEK293_TMG_2hB PRUNE1 protein_coding protein_coding 26.28255 30.68277 22.34198 1.855324 0.07945982 -0.4574962 0.9609745 3.5250699 0.000000 0.8306564 0.0000000 -8.46559492 0.03240000 0.1141000 0.00000000 -0.11410000 3.047282e-17 2.228017e-21 FALSE TRUE
ENST00000450884 ENSG00000143363 HEK293_OSMI2_2hA HEK293_TMG_2hB PRUNE1 protein_coding protein_coding 26.28255 30.68277 22.34198 1.855324 0.07945982 -0.4574962 1.5198654 1.6015956 1.635612 0.3655113 0.3331391 0.03013434 0.05871250 0.0528000 0.07316667 0.02036667 6.808312e-01 2.228017e-21 FALSE TRUE
MSTRG.2192.3 ENSG00000143363 HEK293_OSMI2_2hA HEK293_TMG_2hB PRUNE1 protein_coding   26.28255 30.68277 22.34198 1.855324 0.07945982 -0.4574962 2.9797886 2.5631624 2.414252 0.2361468 0.6812623 -0.08600267 0.11450417 0.0838000 0.10786667 0.02406667 8.011673e-01 2.228017e-21 FALSE TRUE
MSTRG.2192.5 ENSG00000143363 HEK293_OSMI2_2hA HEK293_TMG_2hB PRUNE1 protein_coding   26.28255 30.68277 22.34198 1.855324 0.07945982 -0.4574962 2.9884261 0.6017126 3.479802 0.6017126 0.3561229 2.51221941 0.11872917 0.0223000 0.15586667 0.13356667 6.476311e-02 2.228017e-21 FALSE TRUE
MSTRG.2192.6 ENSG00000143363 HEK293_OSMI2_2hA HEK293_TMG_2hB PRUNE1 protein_coding   26.28255 30.68277 22.34198 1.855324 0.07945982 -0.4574962 1.9899625 1.5515050 2.020782 0.1022189 0.3337127 0.37909803 0.07627083 0.0505000 0.09053333 0.04003333 7.363059e-02 2.228017e-21 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000143363 E001 0.6568746 0.0189966062 4.766136e-01 6.152259e-01 1 151008412 151008419 8 + 0.130 0.281 1.380
ENSG00000143363 E002 4.4375836 0.0046117617 1.070525e-01 2.011883e-01 1 151008420 151008432 13 + 0.537 0.830 1.236
ENSG00000143363 E003 10.3752173 0.0017064627 2.730689e-01 4.120502e-01 1 151008433 151008448 16 + 0.939 1.118 0.658
ENSG00000143363 E004 10.5569216 0.0016043083 2.314327e-01 3.641940e-01 1 151008449 151008449 1 + 0.939 1.128 0.693
ENSG00000143363 E005 13.9032504 0.0014880845 7.253496e-01 8.186548e-01 1 151008450 151008460 11 + 1.110 1.208 0.352
ENSG00000143363 E006 15.7832955 0.0029623554 7.959131e-01 8.696848e-01 1 151008461 151008466 6 + 1.195 1.240 0.158
ENSG00000143363 E007 27.0550601 0.0021332497 2.113932e-01 3.401232e-01 1 151008467 151008476 10 + 1.451 1.433 -0.063
ENSG00000143363 E008 27.0550601 0.0021332497 2.113932e-01 3.401232e-01 1 151008477 151008477 1 + 1.451 1.433 -0.063
ENSG00000143363 E009 38.7744769 0.0005868102 2.126749e-02 5.415043e-02 1 151008478 151008481 4 + 1.626 1.566 -0.204
ENSG00000143363 E010 40.4352392 0.0005627482 1.324733e-02 3.649258e-02 1 151008482 151008482 1 + 1.647 1.580 -0.228
ENSG00000143363 E011 65.5038346 0.0023166402 6.798752e-03 2.070013e-02 1 151008483 151008529 47 + 1.850 1.788 -0.210
ENSG00000143363 E012 150.1451054 0.0022405094 2.025423e-03 7.305847e-03 1 151008530 151008671 142 + 2.196 2.155 -0.139
ENSG00000143363 E013 130.1070308 0.0039024046 1.423138e-02 3.875346e-02 1 151017812 151017904 93 + 2.131 2.096 -0.116
ENSG00000143363 E014 67.8509204 0.0171084802 8.301780e-02 1.642745e-01 1 151018467 151018556 90 + 1.863 1.808 -0.184
ENSG00000143363 E015 39.3046430 0.0320464476 2.349721e-01 3.683128e-01 1 151018557 151018559 3 + 1.622 1.587 -0.118
ENSG00000143363 E016 93.7166655 0.0070907282 6.586330e-02 1.364821e-01 1 151018560 151018669 110 + 1.987 1.960 -0.090
ENSG00000143363 E017 152.9037940 0.0007745773 1.564598e-05 9.943254e-05 1 151024611 151024741 131 + 2.217 2.156 -0.205
ENSG00000143363 E018 100.4499361 0.0003660913 6.781688e-04 2.819148e-03 1 151024742 151024795 54 + 2.033 1.984 -0.164
ENSG00000143363 E019 170.7284827 0.0029746993 3.156901e-02 7.501134e-02 1 151025515 151025673 159 + 2.237 2.231 -0.019
ENSG00000143363 E020 146.0219253 0.0028612773 7.603698e-02 1.531711e-01 1 151027233 151027327 95 + 2.163 2.168 0.017
ENSG00000143363 E021 145.8673335 0.0003092814 4.283927e-02 9.624736e-02 1 151028786 151028944 159 + 2.158 2.169 0.037
ENSG00000143363 E022 0.1472490 0.0435727178 3.710227e-01   1 151028945 151028953 9 + 0.130 0.000 -16.333
ENSG00000143363 E023 8.3155442 0.0021143955 4.827902e-02 1.061230e-01 1 151031372 151031464 93 + 0.770 1.065 1.117
ENSG00000143363 E024 1481.1962191 0.0063703911 8.472753e-06 5.723028e-05 1 151033806 151035713 1908 + 3.064 3.226 0.539