ENSG00000143322

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000502732 ENSG00000143322 HEK293_OSMI2_2hA HEK293_TMG_2hB ABL2 protein_coding protein_coding 6.224174 4.268029 7.489783 0.4199253 0.07066409 0.8099027 5.021449 3.7636678 5.590630 0.3551942 0.08364812 0.5696217 0.8242125 0.8827333 0.7465667 -0.1361667 0.001474406 0.001095015 FALSE TRUE
ENST00000507173 ENSG00000143322 HEK293_OSMI2_2hA HEK293_TMG_2hB ABL2 protein_coding protein_coding 6.224174 4.268029 7.489783 0.4199253 0.07066409 0.8099027 1.096636 0.4783572 1.888203 0.1027156 0.10490945 1.9586257 0.1601792 0.1104333 0.2520000 0.1415667 0.001095015 0.001095015 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000143322 E001 815.2424552 0.0091671428 5.228943e-11 9.674847e-10 1 179099330 179104047 4718 - 2.784 3.031 0.822
ENSG00000143322 E002 311.1942195 0.0168021306 6.999098e-08 7.322904e-07 1 179104048 179107598 3551 - 2.582 2.329 -0.846
ENSG00000143322 E003 33.8971788 0.0006209945 2.227562e-01 3.536661e-01 1 179107599 179107717 119 - 1.550 1.540 -0.034
ENSG00000143322 E004 214.5934300 0.0002412188 8.912245e-02 1.737893e-01 1 179107718 179108898 1181 - 2.286 2.389 0.346
ENSG00000143322 E005 37.0872904 0.0006187045 6.125229e-01 7.314437e-01 1 179108899 179109207 309 - 1.537 1.629 0.311
ENSG00000143322 E006 61.6216452 0.0017519220 2.348133e-01 3.681409e-01 1 179109208 179109441 234 - 1.791 1.794 0.013
ENSG00000143322 E007 58.0982565 0.0053367539 2.229551e-01 3.538988e-01 1 179110282 179110455 174 - 1.774 1.764 -0.036
ENSG00000143322 E008 0.2214452 0.0567338767 3.545663e-01   1 179110581 179110804 224 - 0.000 0.150 11.193
ENSG00000143322 E009 0.2214452 0.0567338767 3.545663e-01   1 179110805 179110845 41 - 0.000 0.150 11.193
ENSG00000143322 E010 45.3700551 0.0054603226 3.997756e-01 5.435103e-01 1 179112309 179112398 90 - 1.663 1.674 0.036
ENSG00000143322 E011 48.7215003 0.0004532138 3.860041e-02 8.844941e-02 1 179114878 179115030 153 - 1.714 1.673 -0.139
ENSG00000143322 E012 0.0000000       1 179116823 179116851 29 -      
ENSG00000143322 E013 0.0000000       1 179116852 179116856 5 -      
ENSG00000143322 E014 0.1482932 0.0410568194 3.578745e-01   1 179116857 179117331 475 - 0.000 0.149 11.184
ENSG00000143322 E015 46.9943460 0.0045592131 2.238144e-02 5.646836e-02 1 179117332 179117516 185 - 1.709 1.633 -0.260
ENSG00000143322 E016 46.1667974 0.0018330233 2.357331e-03 8.330646e-03 1 179118587 179118764 178 - 1.716 1.611 -0.356
ENSG00000143322 E017 0.0000000       1 179118765 179119484 720 -      
ENSG00000143322 E018 31.2336830 0.0048904304 1.572537e-02 4.211725e-02 1 179120190 179120274 85 - 1.554 1.447 -0.364
ENSG00000143322 E019 53.3354359 0.0065938339 3.442526e-03 1.155952e-02 1 179121595 179121867 273 - 1.782 1.663 -0.404
ENSG00000143322 E020 55.6195433 0.0005943721 5.914771e-04 2.502280e-03 1 179126377 179126672 296 - 1.791 1.688 -0.349
ENSG00000143322 E021 0.0000000       1 179131149 179131153 5 -      
ENSG00000143322 E022 0.0000000       1 179131154 179131211 58 -      
ENSG00000143322 E023 0.0000000       1 179131212 179131310 99 -      
ENSG00000143322 E024 33.2831893 0.0011418775 2.173018e-06 1.676597e-05 1 179131311 179131481 171 - 1.617 1.374 -0.837
ENSG00000143322 E025 0.1817044 0.0400114843 3.556505e-01   1 179131482 179133311 1830 - 0.000 0.150 11.189
ENSG00000143322 E026 6.4100934 0.0272450046 1.559956e-01 2.697835e-01 1 179133312 179133374 63 - 0.927 0.773 -0.597
ENSG00000143322 E027 0.1451727 0.0441572462 6.679046e-01   1 179133375 179134196 822 - 0.099 0.000 -10.111
ENSG00000143322 E028 0.0000000       1 179142933 179143089 157 -      
ENSG00000143322 E029 26.2461838 0.0146825255 2.276065e-04 1.081771e-03 1 179229241 179229684 444 - 1.534 1.251 -0.979