ENSG00000143252

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000342751 ENSG00000143252 HEK293_OSMI2_2hA HEK293_TMG_2hB SDHC protein_coding protein_coding 256.8228 433.8472 143.5074 8.959809 3.507636 -1.595995 20.36200 37.392270 10.38995 1.202343 1.084044 -1.846549 0.07722500 0.08633333 0.07243333 -0.01390000 0.517961285 0.004537872 FALSE  
ENST00000367975 ENSG00000143252 HEK293_OSMI2_2hA HEK293_TMG_2hB SDHC protein_coding protein_coding 256.8228 433.8472 143.5074 8.959809 3.507636 -1.595995 185.07462 321.560195 99.34025 7.583282 4.614430 -1.694538 0.71647917 0.74116667 0.69403333 -0.04713333 0.723931002 0.004537872 FALSE  
ENST00000432287 ENSG00000143252 HEK293_OSMI2_2hA HEK293_TMG_2hB SDHC protein_coding protein_coding 256.8228 433.8472 143.5074 8.959809 3.507636 -1.595995 28.45203 53.897421 13.30704 2.351573 1.439499 -2.017210 0.10623333 0.12440000 0.09236667 -0.03203333 0.134066274 0.004537872 FALSE  
MSTRG.2455.1 ENSG00000143252 HEK293_OSMI2_2hA HEK293_TMG_2hB SDHC protein_coding   256.8228 433.8472 143.5074 8.959809 3.507636 -1.595995 12.19275 5.942159 14.91807 2.686029 4.603341 1.326543 0.05756667 0.01346667 0.10260000 0.08913333 0.004537872 0.004537872    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000143252 E001 1.062101 1.610995e-02 7.285313e-01 8.209800e-01 1 161314322 161314368 47 + 0.202 0.277 0.590
ENSG00000143252 E002 1.183427 1.126253e-02 2.385388e-01 3.724407e-01 1 161314369 161314371 3 + 0.444 0.234 -1.317
ENSG00000143252 E003 2.501428 4.307712e-02 9.200340e-01 9.534937e-01 1 161314372 161314380 9 + 0.444 0.474 0.150
ENSG00000143252 E004 2.501428 4.307712e-02 9.200340e-01 9.534937e-01 1 161314381 161314381 1 + 0.444 0.474 0.150
ENSG00000143252 E005 2.652944 8.113987e-02 7.525675e-01 8.387209e-01 1 161314382 161314387 6 + 0.529 0.475 -0.260
ENSG00000143252 E006 7.461856 6.043665e-02 1.535821e-02 4.130208e-02 1 161314388 161314390 3 + 1.110 0.728 -1.452
ENSG00000143252 E007 1323.446164 6.098856e-04 1.865630e-03 6.807883e-03 1 161314391 161314425 35 + 3.052 3.017 -0.115
ENSG00000143252 E008 16.755098 1.396608e-03 1.877247e-03 6.844475e-03 1 161314426 161314874 449 + 1.349 1.082 -0.947
ENSG00000143252 E009 1769.612622 4.306116e-04 6.902519e-02 1.417565e-01 1 161323614 161323670 57 + 3.158 3.148 -0.033
ENSG00000143252 E010 3.642901 6.775956e-03 2.042855e-02 5.239318e-02 1 161326651 161326768 118 + 0.841 0.497 -1.469
ENSG00000143252 E011 2032.635287 6.666910e-05 5.622126e-05 3.127848e-04 1 161328396 161328497 102 + 3.229 3.206 -0.077
ENSG00000143252 E012 4.680110 3.507315e-03 5.018574e-02 1.094884e-01 1 161339562 161339588 27 + 0.877 0.606 -1.105
ENSG00000143252 E013 1782.289050 1.776122e-04 5.868991e-01 7.103329e-01 1 161340594 161340655 62 + 3.147 3.155 0.026
ENSG00000143252 E014 2270.511299 5.960154e-05 5.887395e-01 7.119236e-01 1 161356677 161356840 164 + 3.252 3.261 0.031
ENSG00000143252 E015 3475.421599 1.169218e-03 8.639232e-07 7.275735e-06 1 161362329 161363142 814 + 3.375 3.459 0.282
ENSG00000143252 E016 263.324989 3.617021e-03 1.810742e-01 3.025654e-01 1 161363143 161363206 64 + 2.271 2.340 0.232
ENSG00000143252 E017 18.203668 3.686457e-02 3.985033e-14 1.199099e-12 1 161366178 161366229 52 + 1.717 0.830 -3.148
ENSG00000143252 E018 1.733840 1.038407e-02 2.371415e-02 5.922368e-02 1 161385522 161385598 77 + 0.659 0.277 -1.997
ENSG00000143252 E019 1.649045 9.218817e-02 5.903764e-01 7.132338e-01 1 161386462 161386511 50 + 0.444 0.351 -0.517
ENSG00000143252 E020 2.641203 1.036938e-02 4.309303e-01 5.735333e-01 1 161386512 161386635 124 + 0.598 0.472 -0.596