ENSG00000143207

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000367666 ENSG00000143207 HEK293_OSMI2_2hA HEK293_TMG_2hB COP1 protein_coding protein_coding 16.59189 11.76071 21.43683 1.698647 0.4018004 0.865563 8.907898 7.856929 8.759634 1.5810282 0.5711086 0.1567159 0.5520375 0.6580667 0.4079000 -0.25016667 0.0002063355 0.0002063355 FALSE TRUE
ENST00000367669 ENSG00000143207 HEK293_OSMI2_2hA HEK293_TMG_2hB COP1 protein_coding protein_coding 16.59189 11.76071 21.43683 1.698647 0.4018004 0.865563 3.027262 1.370505 6.374426 0.4707263 0.8014749 2.2093608 0.1599958 0.1252667 0.2974667 0.17220000 0.0949462564 0.0002063355 FALSE TRUE
MSTRG.2642.7 ENSG00000143207 HEK293_OSMI2_2hA HEK293_TMG_2hB COP1 protein_coding   16.59189 11.76071 21.43683 1.698647 0.4018004 0.865563 3.222303 1.924986 5.173193 0.3161500 0.5738994 1.4215183 0.1922083 0.1670000 0.2418333 0.07483333 0.3723698151 0.0002063355 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000143207 E001 0.0000000       1 175944831 175944831 1 -      
ENSG00000143207 E002 4.4994389 0.0036528390 2.117206e-01 3.405169e-01 1 175944832 175944847 16 - 0.661 0.832 0.693
ENSG00000143207 E003 4.4994389 0.0036528390 2.117206e-01 3.405169e-01 1 175944848 175944852 5 - 0.661 0.832 0.693
ENSG00000143207 E004 33.7891862 0.0111642905 3.757615e-03 1.246160e-02 1 175944853 175944915 63 - 1.429 1.665 0.807
ENSG00000143207 E005 142.8544443 0.0069245799 4.532369e-07 4.042769e-06 1 175944916 175945152 237 - 2.032 2.287 0.852
ENSG00000143207 E006 78.9631597 0.0019262231 5.165955e-05 2.900120e-04 1 175945153 175945170 18 - 1.823 2.002 0.602
ENSG00000143207 E007 97.6171395 0.0005500569 2.469473e-07 2.325105e-06 1 175947195 175947239 45 - 1.910 2.096 0.624
ENSG00000143207 E008 0.2965864 0.0438328438 1.038234e-01   1 175947240 175947326 87 - 0.000 0.261 12.309
ENSG00000143207 E009 174.9296692 0.0001990512 7.007238e-09 8.890899e-08 1 175986943 175987103 161 - 2.177 2.328 0.505
ENSG00000143207 E010 145.2048096 0.0004370074 1.915631e-04 9.277805e-04 1 175988288 175988412 125 - 2.117 2.227 0.367
ENSG00000143207 E011 4.2438556 0.0042827943 3.641058e-01 5.085092e-01 1 175988413 175989361 949 - 0.768 0.635 -0.554
ENSG00000143207 E012 150.8017174 0.0002581576 1.470813e-03 5.541900e-03 1 175989362 175989479 118 - 2.142 2.232 0.300
ENSG00000143207 E013 153.8519472 0.0004016108 9.592810e-03 2.776311e-02 1 176027572 176027688 117 - 2.159 2.233 0.248
ENSG00000143207 E014 86.5792858 0.0040902892 6.566821e-02 1.361627e-01 1 176043186 176043203 18 - 1.905 1.993 0.295
ENSG00000143207 E015 81.6466499 0.0030456686 2.582795e-02 6.358545e-02 1 176043204 176043215 12 - 1.872 1.973 0.338
ENSG00000143207 E016 124.6381008 0.0002552802 2.397312e-01 3.738094e-01 1 176043216 176043267 52 - 2.084 2.119 0.120
ENSG00000143207 E017 133.3321369 0.0006487813 4.765524e-01 6.151679e-01 1 176043710 176043809 100 - 2.118 2.138 0.067
ENSG00000143207 E018 66.9905628 0.0003546124 3.198823e-01 4.629616e-01 1 176043810 176043818 9 - 1.850 1.805 -0.152
ENSG00000143207 E019 157.2310763 0.0002191255 2.337621e-01 3.668601e-01 1 176046181 176046324 144 - 2.215 2.179 -0.119
ENSG00000143207 E020 140.8138078 0.0005834542 5.108666e-02 1.111072e-01 1 176081152 176081287 136 - 2.180 2.116 -0.212
ENSG00000143207 E021 115.9017379 0.0003040806 3.487736e-01 4.930005e-01 1 176085776 176085865 90 - 2.083 2.050 -0.110
ENSG00000143207 E022 69.2140582 0.0027098396 1.067439e-01 2.007436e-01 1 176085866 176085890 25 - 1.881 1.798 -0.280
ENSG00000143207 E023 75.5938951 0.0003835635 2.032739e-04 9.778487e-04 1 176116624 176116645 22 - 1.946 1.788 -0.531
ENSG00000143207 E024 83.5025659 0.0003696071 9.566882e-03 2.770179e-02 1 176116646 176116681 36 - 1.968 1.863 -0.352
ENSG00000143207 E025 0.4439371 0.0215602802 1.959484e-01 3.211551e-01 1 176133847 176133900 54 - 0.247 0.000 -11.789
ENSG00000143207 E026 94.9853243 0.0002941284 3.733327e-03 1.239241e-02 1 176135010 176135086 77 - 2.024 1.914 -0.368
ENSG00000143207 E027 70.8320403 0.0053423155 1.075271e-04 5.567240e-04 1 176136488 176136547 60 - 1.934 1.705 -0.772
ENSG00000143207 E028 85.8327985 0.0061115018 9.474657e-03 2.747464e-02 1 176149006 176149074 69 - 1.992 1.839 -0.516
ENSG00000143207 E029 110.9093439 0.0048590894 1.326374e-03 5.063323e-03 1 176162869 176162988 120 - 2.108 1.942 -0.556
ENSG00000143207 E030 37.3048604 0.0164231219 9.675571e-02 1.855159e-01 1 176163815 176163826 12 - 1.638 1.479 -0.542
ENSG00000143207 E031 72.6862390 0.0173864879 4.931152e-02 1.079407e-01 1 176163827 176163891 65 - 1.926 1.756 -0.575
ENSG00000143207 E032 0.0000000       1 176168665 176168748 84 -      
ENSG00000143207 E033 67.7291974 0.0004595985 1.843376e-08 2.164511e-07 1 176175910 176176007 98 - 1.925 1.664 -0.883
ENSG00000143207 E034 51.6611189 0.0111710853 3.501961e-06 2.583071e-05 1 176184633 176184692 60 - 1.836 1.473 -1.235
ENSG00000143207 E035 0.1472490 0.0445253460 7.999307e-01   1 176201261 176201345 85 - 0.099 0.000 -10.204
ENSG00000143207 E036 0.1451727 0.0440679595 8.002656e-01   1 176206349 176206571 223 - 0.099 0.000 -10.204
ENSG00000143207 E037 96.1005870 0.0042766575 6.323248e-09 8.097887e-08 1 176206572 176207286 715 - 2.088 1.788 -1.010