ENSG00000143198

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000367888 ENSG00000143198 HEK293_OSMI2_2hA HEK293_TMG_2hB MGST3 protein_coding protein_coding 119.2924 207.4714 68.19696 9.510403 0.2023723 -1.604991 25.92263 43.69524 18.89700 5.291813 0.9346761 -1.208886 0.2225792 0.2092333 0.2771333 0.06790000 0.094708111 0.001085181 FALSE  
ENST00000367889 ENSG00000143198 HEK293_OSMI2_2hA HEK293_TMG_2hB MGST3 protein_coding protein_coding 119.2924 207.4714 68.19696 9.510403 0.2023723 -1.604991 88.53275 157.96863 45.66718 4.303173 1.0068190 -1.790184 0.7310208 0.7626667 0.6696000 -0.09306667 0.006856037 0.001085181 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000143198 E001 67.6760940 3.821037e-04 4.300764e-08 4.701482e-07 1 165631213 165631225 13 + 1.928 1.671 -0.868
ENSG00000143198 E002 124.5638894 3.473320e-04 1.630479e-03 6.058794e-03 1 165631226 165631233 8 + 2.080 1.964 -0.389
ENSG00000143198 E003 173.0300417 1.790803e-03 5.411039e-02 1.164416e-01 1 165631234 165631236 3 + 2.185 2.116 -0.231
ENSG00000143198 E004 189.3662802 1.487059e-03 3.361357e-02 7.899216e-02 1 165631237 165631238 2 + 2.227 2.155 -0.240
ENSG00000143198 E005 193.7936098 1.333815e-03 1.495477e-02 4.038224e-02 1 165631239 165631239 1 + 2.244 2.163 -0.270
ENSG00000143198 E006 398.4011185 1.418780e-03 4.124328e-03 1.348978e-02 1 165631240 165631254 15 + 2.552 2.477 -0.248
ENSG00000143198 E007 430.7784313 1.140108e-03 6.016352e-04 2.539333e-03 1 165631255 165631257 3 + 2.592 2.509 -0.276
ENSG00000143198 E008 1016.9332745 2.388389e-04 2.424582e-01 3.770482e-01 1 165631258 165631292 35 + 2.910 2.896 -0.045
ENSG00000143198 E009 1005.2355201 2.199303e-04 5.168461e-01 6.513551e-01 1 165631293 165631293 1 + 2.898 2.893 -0.019
ENSG00000143198 E010 1.6629523 2.025031e-02 1.194059e-02 3.338857e-02 1 165632063 165632142 80 + 0.669 0.229 -2.402
ENSG00000143198 E011 5.1801677 3.211218e-03 7.948304e-01 8.689379e-01 1 165632231 165632239 9 + 0.669 0.712 0.181
ENSG00000143198 E012 5.9550449 3.838338e-03 4.863547e-01 6.241047e-01 1 165632240 165632274 35 + 0.669 0.780 0.453
ENSG00000143198 E013 0.7384472 6.477656e-02 7.793484e-02 1.561582e-01 1 165635376 165635436 61 + 0.452 0.128 -2.415
ENSG00000143198 E014 3.0132202 2.434276e-02 1.284580e-01 2.320144e-01 1 165635727 165635822 96 + 0.722 0.463 -1.166
ENSG00000143198 E015 1.2073619 1.119720e-01 7.680406e-02 1.543782e-01 1 165636775 165637149 375 + 0.537 0.184 -2.208
ENSG00000143198 E016 3.8718239 4.002248e-03 2.609873e-05 1.575328e-04 1 165645661 165647895 2235 + 1.007 0.408 -2.556
ENSG00000143198 E017 0.1817044 4.067264e-02 1.000000e+00   1 165648450 165648670 221 + 0.000 0.069 7.917
ENSG00000143198 E018 1.6575400 8.446952e-03 5.483777e-02 1.177180e-01 1 165648792 165649754 963 + 0.608 0.271 -1.819
ENSG00000143198 E019 8.2747686 2.097386e-03 5.880419e-01 7.112782e-01 1 165649755 165649837 83 + 0.813 0.890 0.296
ENSG00000143198 E020 10.7909548 1.566810e-03 1.322750e-02 3.644272e-02 1 165649838 165649840 3 + 0.669 1.022 1.377
ENSG00000143198 E021 1910.7559386 1.372998e-04 5.719266e-01 6.981300e-01 1 165649841 165649964 124 + 3.165 3.175 0.033
ENSG00000143198 E022 20.4506401 9.987540e-04 9.316726e-15 3.078176e-13 1 165649965 165651013 1049 + 1.629 1.037 -2.073
ENSG00000143198 E023 1978.3278731 7.020198e-05 5.197887e-04 2.233897e-03 1 165651014 165651087 74 + 3.158 3.196 0.125
ENSG00000143198 E024 14.7707892 1.235587e-03 2.328063e-07 2.204121e-06 1 165651088 165651892 805 + 1.426 0.961 -1.657
ENSG00000143198 E025 1498.3750232 1.254390e-03 2.748012e-01 4.140256e-01 1 165651978 165652035 58 + 3.049 3.075 0.088
ENSG00000143198 E026 3.5783831 4.632977e-03 1.066832e-03 4.190420e-03 1 165653697 165653801 105 + 0.921 0.437 -2.082
ENSG00000143198 E027 11.0411994 1.157879e-02 2.158196e-06 1.666247e-05 1 165653833 165654278 446 + 1.350 0.837 -1.868
ENSG00000143198 E028 1614.8769512 4.674673e-04 3.950945e-02 9.012374e-02 1 165654279 165654351 73 + 3.075 3.108 0.112
ENSG00000143198 E029 1571.8294188 6.875196e-04 2.286761e-03 8.110303e-03 1 165655368 165656136 769 + 3.048 3.100 0.174
ENSG00000143198 E030 0.1482932 4.151973e-02 1.000000e+00   1 165661429 165661796 368 + 0.000 0.069 7.906