ENSG00000143195

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000271417 ENSG00000143195 HEK293_OSMI2_2hA HEK293_TMG_2hB ILDR2 protein_coding protein_coding 1.146762 0.9643576 1.504648 0.0747601 0.1987779 0.6364597 0.6627796 0.7922035 0.48201876 0.09054851 0.02523775 -0.7052549 0.61992917 0.8269000 0.33873333 -0.48816667 5.743157e-03 9.586925e-07 FALSE TRUE
ENST00000414590 ENSG00000143195 HEK293_OSMI2_2hA HEK293_TMG_2hB ILDR2 protein_coding processed_transcript 1.146762 0.9643576 1.504648 0.0747601 0.1987779 0.6364597 0.0566910 0.1242496 0.03243853 0.09341220 0.03243853 -1.6614707 0.05439167 0.1271667 0.01890000 -0.10826667 5.235250e-01 9.586925e-07   FALSE
ENST00000469934 ENSG00000143195 HEK293_OSMI2_2hA HEK293_TMG_2hB ILDR2 protein_coding protein_coding 1.146762 0.9643576 1.504648 0.0747601 0.1987779 0.6364597 0.0383135 0.0000000 0.12043366 0.00000000 0.12043366 3.7052443 0.03257500 0.0000000 0.07013333 0.07013333 8.567351e-01 9.586925e-07 FALSE TRUE
ENST00000525740 ENSG00000143195 HEK293_OSMI2_2hA HEK293_TMG_2hB ILDR2 protein_coding protein_coding 1.146762 0.9643576 1.504648 0.0747601 0.1987779 0.6364597 0.0744616 0.0111129 0.08967332 0.01111290 0.04505689 2.2390825 0.06695000 0.0105000 0.06623333 0.05573333 5.118587e-01 9.586925e-07 FALSE TRUE
ENST00000614979 ENSG00000143195 HEK293_OSMI2_2hA HEK293_TMG_2hB ILDR2 protein_coding processed_transcript 1.146762 0.9643576 1.504648 0.0747601 0.1987779 0.6364597 0.2614396 0.0000000 0.69183764 0.00000000 0.19502694 6.1330654 0.18215000 0.0000000 0.44496667 0.44496667 9.586925e-07 9.586925e-07   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000143195 E001 0.7384326 0.0853826115 5.461895e-01 6.764074e-01 1 166895711 166896101 391 - 0.130 0.283 1.401
ENSG00000143195 E002 0.2214452 0.0422715179 6.978275e-01   1 166907053 166907182 130 - 0.000 0.116 8.417
ENSG00000143195 E003 0.0000000       1 166908040 166908063 24 -      
ENSG00000143195 E004 0.0000000       1 166908064 166908104 41 -      
ENSG00000143195 E005 187.5609688 0.0198043850 8.401884e-06 5.679817e-05 1 166908187 166917791 9605 - 2.098 2.363 0.886
ENSG00000143195 E006 35.0549643 0.0008021709 5.083325e-04 2.191074e-03 1 166917792 166918865 1074 - 1.590 1.518 -0.248
ENSG00000143195 E007 14.1940538 0.0040218908 4.469780e-02 9.964655e-02 1 166918866 166919390 525 - 1.213 1.149 -0.227
ENSG00000143195 E008 10.8183243 0.0020625269 8.744511e-01 9.232894e-01 1 166920707 166921379 673 - 1.002 1.099 0.354
ENSG00000143195 E009 8.9625969 0.0019639502 3.230965e-01 4.664197e-01 1 166922593 166922809 217 - 0.987 0.992 0.020
ENSG00000143195 E010 7.4078383 0.0313536997 1.764400e-02 4.636965e-02 1 166927067 166927180 114 - 1.032 0.812 -0.833
ENSG00000143195 E011 4.9582512 0.1772395211 3.699227e-01 5.143315e-01 1 166935301 166935477 177 - 0.842 0.702 -0.561
ENSG00000143195 E012 3.7160526 0.0094417931 5.955017e-01 7.175815e-01 1 166936591 166936737 147 - 0.651 0.668 0.071
ENSG00000143195 E013 2.3981507 0.0686307077 2.682895e-01 4.067336e-01 1 166939514 166939570 57 - 0.578 0.455 -0.587
ENSG00000143195 E014 6.8632753 0.0038917903 1.059970e-02 3.020851e-02 1 166956733 166956852 120 - 0.987 0.791 -0.749
ENSG00000143195 E015 10.1646560 0.0022540783 2.934178e-05 1.750114e-04 1 166957769 166958101 333 - 1.194 0.886 -1.127
ENSG00000143195 E016 2.9746027 0.0077747286 3.108470e-03 1.058565e-02 1 166975223 166975540 318 - 0.769 0.402 -1.679