ENSG00000143190

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000367866 ENSG00000143190 HEK293_OSMI2_2hA HEK293_TMG_2hB POU2F1 protein_coding protein_coding 4.10262 3.552939 3.603931 0.8603853 0.02908852 0.02050113 1.531408 0.0000000 2.9579237 0.0000000 0.27589513 8.213310 0.3545583 0.0000000 0.82203333 0.8220333 1.775655e-11 1.775655e-11 FALSE TRUE
ENST00000443275 ENSG00000143190 HEK293_OSMI2_2hA HEK293_TMG_2hB POU2F1 protein_coding protein_coding 4.10262 3.552939 3.603931 0.8603853 0.02908852 0.02050113 1.128711 0.9927968 0.2490357 0.1166346 0.24903568 -1.952807 0.2697250 0.3096667 0.06800000 -0.2416667 1.275650e-01 1.775655e-11 FALSE TRUE
MSTRG.2528.1 ENSG00000143190 HEK293_OSMI2_2hA HEK293_TMG_2hB POU2F1 protein_coding   4.10262 3.552939 3.603931 0.8603853 0.02908852 0.02050113 1.022838 2.3591394 0.1153376 0.7674203 0.07020109 -4.240472 0.2792750 0.6407333 0.03173333 -0.6090000 8.836379e-08 1.775655e-11 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000143190 E001 0.2966881 0.0273758096 3.318761e-01   1 167220826 167220875 50 + 0.187 0.000 -11.307
ENSG00000143190 E002 0.2966881 0.0273758096 3.318761e-01   1 167220876 167220885 10 + 0.187 0.000 -13.451
ENSG00000143190 E003 0.2966881 0.0273758096 3.318761e-01   1 167220886 167220889 4 + 0.187 0.000 -13.451
ENSG00000143190 E004 0.2966881 0.0273758096 3.318761e-01   1 167220890 167220890 1 + 0.187 0.000 -13.451
ENSG00000143190 E005 0.4418608 0.0306552271 1.643664e-01 2.808629e-01 1 167220891 167220894 4 + 0.257 0.000 -13.982
ENSG00000143190 E006 0.5901540 0.0207920123 5.104198e-01 6.456400e-01 1 167220895 167220897 3 + 0.257 0.144 -1.044
ENSG00000143190 E007 8.9259555 0.0019335681 8.014022e-01 8.734711e-01 1 167220898 167220958 61 + 0.984 1.018 0.127
ENSG00000143190 E008 0.1515154 0.0442704556 7.099896e-01   1 167241407 167241610 204 + 0.104 0.000 -12.364
ENSG00000143190 E009 0.0000000       1 167251919 167251987 69 +      
ENSG00000143190 E010 0.2944980 0.3445787914 4.331159e-01   1 167257820 167257917 98 + 0.187 0.000 -12.505
ENSG00000143190 E011 0.1515154 0.0442704556 7.099896e-01   1 167268428 167268596 169 + 0.104 0.000 -12.364
ENSG00000143190 E012 0.0000000       1 167274438 167274524 87 +      
ENSG00000143190 E013 1.0307552 0.2265888761 5.713176e-01 6.976249e-01 1 167303474 167303574 101 + 0.370 0.247 -0.810
ENSG00000143190 E014 0.7352129 0.0838306720 3.475048e-01 4.917295e-01 1 167319014 167319056 43 + 0.318 0.143 -1.463
ENSG00000143190 E015 0.0000000       1 167329044 167329165 122 +      
ENSG00000143190 E016 0.0000000       1 167329166 167329306 141 +      
ENSG00000143190 E017 10.8519613 0.0015964591 2.388429e-01 3.727865e-01 1 167332470 167332535 66 + 1.127 1.018 -0.397
ENSG00000143190 E018 0.1515154 0.0442704556 7.099896e-01   1 167337970 167338258 289 + 0.104 0.000 -12.364
ENSG00000143190 E019 0.0000000       1 167357460 167357521 62 +      
ENSG00000143190 E020 14.5989019 0.0011919996 1.036617e-01 1.960735e-01 1 167365467 167365567 101 + 1.255 1.119 -0.482
ENSG00000143190 E021 0.0000000       1 167365568 167365569 2 +      
ENSG00000143190 E022 12.3824421 0.0015966894 7.003673e-02 1.434266e-01 1 167370161 167370214 54 + 1.200 1.034 -0.596
ENSG00000143190 E023 10.3833518 0.0016212423 5.629377e-03 1.762962e-02 1 167371917 167371979 63 + 1.169 0.885 -1.043
ENSG00000143190 E024 11.4683551 0.0015647513 4.381356e-02 9.804812e-02 1 167371980 167372036 57 + 1.177 0.984 -0.699
ENSG00000143190 E025 8.6364094 0.0172736403 1.795878e-01 3.006226e-01 1 167374108 167374155 48 + 1.051 0.884 -0.622
ENSG00000143190 E026 13.2473604 0.0055521522 1.445204e-01 2.541725e-01 1 167374156 167374296 141 + 1.214 1.078 -0.486
ENSG00000143190 E027 12.8197714 0.0031228855 4.405514e-02 9.848387e-02 1 167376029 167376155 127 + 1.221 1.034 -0.673
ENSG00000143190 E028 0.1515154 0.0442704556 7.099896e-01   1 167376553 167376587 35 + 0.104 0.000 -12.364
ENSG00000143190 E029 0.3268771 0.0317477648 7.902101e-01   1 167383474 167383856 383 + 0.104 0.144 0.543
ENSG00000143190 E030 14.1940052 0.0106733339 3.657053e-02 8.465721e-02 1 167383857 167383951 95 + 1.268 1.063 -0.732
ENSG00000143190 E031 0.0000000       1 167387181 167387247 67 +      
ENSG00000143190 E032 0.0000000       1 167387248 167387255 8 +      
ENSG00000143190 E033 17.0856725 0.0010954039 1.253101e-01 2.275763e-01 1 167389588 167389676 89 + 1.310 1.191 -0.419
ENSG00000143190 E034 17.0380556 0.0010892279 1.973522e-02 5.092803e-02 1 167389677 167389761 85 + 1.332 1.145 -0.662
ENSG00000143190 E035 22.3277098 0.0008838403 4.908545e-01 6.281854e-01 1 167396286 167396427 142 + 1.388 1.346 -0.146
ENSG00000143190 E036 0.0000000       1 167396533 167396825 293 +      
ENSG00000143190 E037 20.3346781 0.0009258448 3.121152e-01 4.546448e-01 1 167397994 167398133 140 + 1.292 1.376 0.291
ENSG00000143190 E038 20.1663998 0.0015530393 5.200908e-01 6.541127e-01 1 167399186 167399365 180 + 1.298 1.354 0.194
ENSG00000143190 E039 18.4379409 0.0097407572 5.415050e-01 6.724779e-01 1 167401451 167401556 106 + 1.316 1.268 -0.166
ENSG00000143190 E040 39.1659660 0.0007893629 2.203214e-01 3.508025e-01 1 167411959 167412304 346 + 1.579 1.656 0.262
ENSG00000143190 E041 17.9017605 0.0010454854 2.965926e-04 1.366055e-03 1 167413026 167413114 89 + 1.127 1.423 1.040
ENSG00000143190 E042 41.3517557 0.0258077853 5.212901e-02 1.129489e-01 1 167415500 167416048 549 + 1.523 1.735 0.721
ENSG00000143190 E043 9.4585511 0.0105677143 2.121848e-05 1.307840e-04 1 167416049 167416185 137 + 0.726 1.231 1.892
ENSG00000143190 E044 55.7331224 0.0004301782 2.637103e-11 5.126641e-10 1 167416186 167417405 1220 + 1.871 1.551 -1.086
ENSG00000143190 E045 405.7898698 0.0247640903 1.067108e-05 7.046128e-05 1 167417406 167424308 6903 + 2.708 2.444 -0.882
ENSG00000143190 E046 387.8057518 0.0072477818 1.887206e-21 1.423837e-19 1 167424309 167427345 3037 + 2.419 2.735 1.051