ENSG00000143183

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000367881 ENSG00000143183 HEK293_OSMI2_2hA HEK293_TMG_2hB TMCO1 protein_coding protein_coding 134.9959 74.6132 192.0855 18.12851 3.506147 1.364128 28.84822 17.75828 39.25821 4.802486 2.266891 1.144057 0.2137583 0.2352333 0.2049000 -0.03033333 0.5080630714 0.0003817033 FALSE TRUE
ENST00000464650 ENSG00000143183 HEK293_OSMI2_2hA HEK293_TMG_2hB TMCO1 protein_coding protein_coding 134.9959 74.6132 192.0855 18.12851 3.506147 1.364128 61.16341 37.71774 78.86429 9.748190 1.634784 1.063929 0.4761750 0.5022000 0.4107333 -0.09146667 0.0003817033 0.0003817033 FALSE FALSE
ENST00000628579 ENSG00000143183 HEK293_OSMI2_2hA HEK293_TMG_2hB TMCO1 protein_coding protein_coding 134.9959 74.6132 192.0855 18.12851 3.506147 1.364128 36.12987 15.04156 59.20738 2.817423 3.674430 1.976108 0.2522083 0.2067667 0.3077667 0.10100000 0.0031401360 0.0003817033 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000143183 E001 87.538173 1.427332e-02 3.234133e-08 3.618145e-07 1 165724293 165726794 2502 - 2.061 1.612 -1.514
ENSG00000143183 E002 93.614286 2.063104e-03 2.706668e-02 6.612804e-02 1 165726795 165727305 511 - 2.008 1.906 -0.343
ENSG00000143183 E003 301.685494 1.850347e-03 7.857872e-02 1.572147e-01 1 165727306 165727537 232 - 2.458 2.504 0.154
ENSG00000143183 E004 672.672571 1.180986e-03 7.827383e-10 1.184215e-08 1 165727538 165727710 173 - 2.775 2.889 0.380
ENSG00000143183 E005 1441.234742 7.610011e-05 2.289091e-11 4.497163e-10 1 165727711 165728085 375 - 3.132 3.194 0.205
ENSG00000143183 E006 571.838307 1.062759e-04 4.897332e-01 6.271274e-01 1 165728086 165728121 36 - 2.752 2.763 0.036
ENSG00000143183 E007 409.608361 1.396606e-04 7.543597e-01 8.400165e-01 1 165743167 165743168 2 - 2.609 2.615 0.020
ENSG00000143183 E008 448.067608 1.984904e-04 2.563175e-01 3.932665e-01 1 165743169 165743178 10 - 2.643 2.664 0.070
ENSG00000143183 E009 934.031167 3.182823e-04 5.329836e-01 6.652489e-01 1 165743179 165743311 133 - 2.965 2.972 0.024
ENSG00000143183 E010 628.677742 1.256476e-04 1.052022e-01 1.984016e-01 1 165752102 165752169 68 - 2.788 2.812 0.080
ENSG00000143183 E011 545.445532 1.527503e-04 1.914432e-01 3.155552e-01 1 165754228 165754274 47 - 2.743 2.722 -0.070
ENSG00000143183 E012 2.086166 1.389375e-02 1.777750e-02 4.665900e-02 1 165754854 165754892 39 - 0.609 0.161 -2.775
ENSG00000143183 E013 2.374208 5.346787e-02 1.410851e-02 3.847272e-02 1 165754893 165754990 98 - 0.657 0.161 -2.985
ENSG00000143183 E014 637.882876 9.990775e-05 2.104956e-01 3.391225e-01 1 165759525 165759584 60 - 2.810 2.791 -0.062
ENSG00000143183 E015 755.083894 2.736721e-04 1.586496e-06 1.261149e-05 1 165768192 165768269 78 - 2.902 2.826 -0.251
ENSG00000143183 E016 23.013953 1.004946e-03 6.454491e-02 1.342890e-01 1 165768482 165768681 200 - 1.319 1.453 0.465
ENSG00000143183 E017 595.153811 8.533941e-04 1.473793e-07 1.448913e-06 1 165768682 165768758 77 - 2.811 2.695 -0.385
ENSG00000143183 E018 511.572527 1.351885e-03 9.331033e-06 6.244652e-05 1 165768759 165768922 164 - 2.745 2.628 -0.391
ENSG00000143183 E019 0.000000       1 165797697 165797813 117 -      
ENSG00000143183 E020 0.000000       1 165799918 165800035 118 -      
ENSG00000143183 E021 1.494878 1.513961e-01 7.430761e-01 8.318278e-01 1 165827470 165827755 286 - 0.425 0.365 -0.334