ENSG00000143158

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000367846 ENSG00000143158 HEK293_OSMI2_2hA HEK293_TMG_2hB MPC2 protein_coding protein_coding 34.06914 40.68929 34.80577 8.225443 0.7813731 -0.2252624 12.866480 15.7279577 15.092621 2.3916212 0.2237118 -0.05944943 0.38020417 0.39413333 0.4340667 0.03993333 5.433762e-01 2.526191e-15 FALSE TRUE
MSTRG.2532.4 ENSG00000143158 HEK293_OSMI2_2hA HEK293_TMG_2hB MPC2 protein_coding   34.06914 40.68929 34.80577 8.225443 0.7813731 -0.2252624 12.951941 24.0295169 8.590415 5.7858165 0.6511123 -1.48292970 0.36634167 0.58200000 0.2466333 -0.33536667 2.526191e-15 2.526191e-15 FALSE TRUE
MSTRG.2532.5 ENSG00000143158 HEK293_OSMI2_2hA HEK293_TMG_2hB MPC2 protein_coding   34.06914 40.68929 34.80577 8.225443 0.7813731 -0.2252624 3.305215 0.0000000 7.237688 0.0000000 1.9357738 9.50137707 0.10753333 0.00000000 0.2088000 0.20880000 8.893953e-15 2.526191e-15 FALSE TRUE
MSTRG.2532.6 ENSG00000143158 HEK293_OSMI2_2hA HEK293_TMG_2hB MPC2 protein_coding   34.06914 40.68929 34.80577 8.225443 0.7813731 -0.2252624 1.632775 0.3967225 3.337573 0.3967225 2.4087138 3.04099895 0.05196667 0.01136667 0.0948000 0.08343333 4.882047e-01 2.526191e-15 FALSE TRUE
MSTRG.2532.7 ENSG00000143158 HEK293_OSMI2_2hA HEK293_TMG_2hB MPC2 protein_coding   34.06914 40.68929 34.80577 8.225443 0.7813731 -0.2252624 2.863118 0.0000000 0.000000 0.0000000 0.0000000 0.00000000 0.08106667 0.00000000 0.0000000 0.00000000   2.526191e-15 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000143158 E001 1.033989 0.0131279159 4.129948e-01 5.565368e-01 1 167916675 167916728 54 - 0.403 0.263 -0.879
ENSG00000143158 E002 74.318716 0.0004547913 5.870256e-20 3.703304e-18 1 167916729 167918038 1310 - 2.061 1.692 -1.244
ENSG00000143158 E003 50.048594 0.0006846564 3.175920e-01 4.604876e-01 1 167918039 167918083 45 - 1.730 1.685 -0.154
ENSG00000143158 E004 59.241629 0.0009805956 8.122936e-01 8.809578e-01 1 167918084 167918095 12 - 1.765 1.782 0.054
ENSG00000143158 E005 573.124038 0.0013153924 1.099321e-01 2.054465e-01 1 167918096 167918359 264 - 2.731 2.764 0.111
ENSG00000143158 E006 330.469990 0.0001569111 1.725309e-03 6.362546e-03 1 167919979 167920010 32 - 2.476 2.542 0.222
ENSG00000143158 E007 429.867115 0.0001441300 3.413908e-01 4.852820e-01 1 167920011 167920090 80 - 2.619 2.640 0.070
ENSG00000143158 E008 460.680482 0.0001459095 2.161308e-01 3.457520e-01 1 167920547 167920631 85 - 2.671 2.656 -0.052
ENSG00000143158 E009 328.825916 0.0002747483 2.235391e-01 3.546208e-01 1 167924497 167924537 41 - 2.528 2.507 -0.070
ENSG00000143158 E010 653.632093 0.0001934037 9.718069e-01 9.863908e-01 1 167935733 167935894 162 - 2.810 2.813 0.010
ENSG00000143158 E011 244.121089 0.0001837230 7.896721e-02 1.578636e-01 1 167935895 167935898 4 - 2.406 2.371 -0.118
ENSG00000143158 E012 389.813670 0.0007264126 8.356750e-02 1.651294e-01 1 167935899 167936040 142 - 2.563 2.598 0.116
ENSG00000143158 E013 1.817591 0.0083444128 3.502344e-03 1.173209e-02 1 167936129 167936133 5 - 0.683 0.192 -2.781
ENSG00000143158 E014 10.649307 0.0180137250 9.352548e-01 9.632347e-01 1 167936134 167936532 399 - 1.068 1.050 -0.063
ENSG00000143158 E015 8.402520 0.0020715346 7.239217e-01 8.176278e-01 1 167936533 167936938 406 - 0.990 0.956 -0.128
ENSG00000143158 E016 4.602693 0.0036814496 7.381512e-01 8.281055e-01 1 167936939 167937072 134 - 0.775 0.735 -0.163