ENSG00000143157

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000367875 ENSG00000143157 HEK293_OSMI2_2hA HEK293_TMG_2hB POGK protein_coding protein_coding 24.46293 18.62592 29.48317 1.156665 0.6363392 0.6622952 3.984883 3.1351913 4.628410 0.2117991 0.2087799 0.5604825 0.16598750 0.1682333 0.1572000 -0.01103333 8.081739e-01 1.833056e-16 FALSE TRUE
ENST00000367876 ENSG00000143157 HEK293_OSMI2_2hA HEK293_TMG_2hB POGK protein_coding protein_coding 24.46293 18.62592 29.48317 1.156665 0.6363392 0.6622952 12.456772 14.0443761 11.115789 1.1391312 0.1217378 -0.3371118 0.54087500 0.7530333 0.3774000 -0.37563333 1.833056e-16 1.833056e-16 FALSE TRUE
ENST00000449930 ENSG00000143157 HEK293_OSMI2_2hA HEK293_TMG_2hB POGK protein_coding protein_coding 24.46293 18.62592 29.48317 1.156665 0.6363392 0.6622952 2.387290 0.8519780 5.312480 0.4491008 1.0173725 2.6263757 0.08862917 0.0459000 0.1789000 0.13300000 2.576092e-02 1.833056e-16 FALSE TRUE
MSTRG.2522.1 ENSG00000143157 HEK293_OSMI2_2hA HEK293_TMG_2hB POGK protein_coding   24.46293 18.62592 29.48317 1.156665 0.6363392 0.6622952 2.117916 0.5943721 3.689910 0.1128523 0.4018219 2.6139814 0.08094583 0.0329000 0.1246667 0.09176667 2.292927e-05 1.833056e-16 FALSE TRUE
MSTRG.2522.5 ENSG00000143157 HEK293_OSMI2_2hA HEK293_TMG_2hB POGK protein_coding   24.46293 18.62592 29.48317 1.156665 0.6363392 0.6622952 3.516071 0.0000000 4.736584 0.0000000 0.8961287 8.8907457 0.12357083 0.0000000 0.1618333 0.16183333 2.583953e-15 1.833056e-16 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000143157 E001 2.1755872 0.0074976123 3.212370e-01 4.644752e-01 1 166839419 166839446 28 + 0.546 0.462 -0.408
ENSG00000143157 E002 4.9319645 0.0036681422 1.355880e-01 2.419284e-01 1 166839447 166839474 28 + 0.819 0.714 -0.422
ENSG00000143157 E003 49.4014869 0.0307786117 1.965767e-02 5.075484e-02 1 166839475 166839604 130 + 1.756 1.630 -0.429
ENSG00000143157 E004 19.4979249 0.0376598269 2.380305e-04 1.125104e-03 1 166839605 166839769 165 + 1.443 1.093 -1.234
ENSG00000143157 E005 3.2024158 0.0897711414 5.495322e-01 6.792540e-01 1 166840089 166840435 347 + 0.639 0.606 -0.143
ENSG00000143157 E006 0.2955422 0.0285026054 1.000000e+00   1 166840436 166840446 11 + 0.107 0.139 0.438
ENSG00000143157 E007 1.4864473 0.0088511403 8.650327e-03 2.540939e-02 1 166840447 166840513 67 + 0.546 0.140 -2.730
ENSG00000143157 E008 126.9065253 0.0076620776 1.927753e-06 1.504643e-05 1 166840955 166841088 134 + 2.167 2.026 -0.474
ENSG00000143157 E009 153.4155432 0.0171314329 6.702609e-03 2.045309e-02 1 166846612 166846738 127 + 2.222 2.147 -0.252
ENSG00000143157 E010 150.3983655 0.0015994752 1.919716e-06 1.498802e-05 1 166847494 166847592 99 + 2.204 2.156 -0.160
ENSG00000143157 E011 1075.9328026 0.0015477692 1.196628e-18 6.546275e-17 1 166848938 166850423 1486 + 3.049 3.013 -0.119
ENSG00000143157 E012 293.6813718 0.0002079237 1.034420e-07 1.047676e-06 1 166850424 166852584 2161 + 2.469 2.475 0.020
ENSG00000143157 E013 1758.4414977 0.0066894383 1.857677e-14 5.880222e-13 1 166852585 166856359 3775 + 3.088 3.372 0.945