ENSG00000143147

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000367838 ENSG00000143147 HEK293_OSMI2_2hA HEK293_TMG_2hB GPR161 protein_coding protein_coding 6.589192 8.98953 5.6526 0.3290684 0.3437065 -0.6683851 0.27764020 1.0799459 0.00000000 0.11078181 0.00000000 -6.7681127 0.03590000 0.11963333 0.00000000 -0.11963333 4.179792e-14 4.179792e-14 FALSE TRUE
ENST00000493800 ENSG00000143147 HEK293_OSMI2_2hA HEK293_TMG_2hB GPR161 protein_coding retained_intron 6.589192 8.98953 5.6526 0.3290684 0.3437065 -0.6683851 0.07048837 0.4748391 0.00000000 0.41002717 0.00000000 -5.5994343 0.00807500 0.05220000 0.00000000 -0.05220000 3.297445e-01 4.179792e-14 FALSE TRUE
ENST00000682931 ENSG00000143147 HEK293_OSMI2_2hA HEK293_TMG_2hB GPR161 protein_coding protein_coding 6.589192 8.98953 5.6526 0.3290684 0.3437065 -0.6683851 2.12479173 2.0212649 2.88486267 0.01824573 0.14082882 0.5111165 0.33966667 0.22533333 0.51683333 0.29150000 4.554642e-05 4.179792e-14 FALSE TRUE
MSTRG.2538.10 ENSG00000143147 HEK293_OSMI2_2hA HEK293_TMG_2hB GPR161 protein_coding   6.589192 8.98953 5.6526 0.3290684 0.3437065 -0.6683851 0.67340808 0.7008972 0.35586456 0.37044990 0.19601997 -0.9583312 0.10452500 0.08010000 0.06626667 -0.01383333 9.992443e-01 4.179792e-14 FALSE TRUE
MSTRG.2538.13 ENSG00000143147 HEK293_OSMI2_2hA HEK293_TMG_2hB GPR161 protein_coding   6.589192 8.98953 5.6526 0.3290684 0.3437065 -0.6683851 0.32090126 1.0317635 0.03498179 0.20115669 0.03498179 -4.5335431 0.04151667 0.11366667 0.00680000 -0.10686667 9.130717e-05 4.179792e-14 FALSE TRUE
MSTRG.2538.7 ENSG00000143147 HEK293_OSMI2_2hA HEK293_TMG_2hB GPR161 protein_coding   6.589192 8.98953 5.6526 0.3290684 0.3437065 -0.6683851 0.99939994 0.4908165 0.87652693 0.30999275 0.23645915 0.8238822 0.15114583 0.05390000 0.15126667 0.09736667 3.791467e-01 4.179792e-14 FALSE TRUE
MSTRG.2538.8 ENSG00000143147 HEK293_OSMI2_2hA HEK293_TMG_2hB GPR161 protein_coding   6.589192 8.98953 5.6526 0.3290684 0.3437065 -0.6683851 0.58630968 0.8030610 0.61758022 0.37788742 0.23229136 -0.3735636 0.09047917 0.08836667 0.10616667 0.01780000 8.643579e-01 4.179792e-14 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000143147 E001 0.0000000       1 168079542 168079542 1 -      
ENSG00000143147 E002 358.9416705 0.0026150591 1.936701e-30 3.362989e-28 1 168079543 168084758 5216 - 2.707 2.405 -1.007
ENSG00000143147 E003 75.0846515 0.0004625363 6.267573e-01 7.426512e-01 1 168084759 168085265 507 - 1.876 1.855 -0.071
ENSG00000143147 E004 17.1003349 0.0010816361 1.471116e-01 2.577629e-01 1 168085266 168085268 3 - 1.179 1.263 0.297
ENSG00000143147 E005 18.7233429 0.0010348181 7.124202e-02 1.453998e-01 1 168085269 168085277 9 - 1.202 1.310 0.382
ENSG00000143147 E006 64.5691469 0.0005080893 3.167307e-05 1.873734e-04 1 168085278 168085514 237 - 1.697 1.847 0.507
ENSG00000143147 E007 100.9154284 0.0021754110 1.128624e-07 1.135499e-06 1 168085515 168085796 282 - 1.864 2.046 0.609
ENSG00000143147 E008 64.7408099 0.0093506672 3.490758e-02 8.147870e-02 1 168087585 168087704 120 - 1.737 1.828 0.306
ENSG00000143147 E009 2.3604877 0.0066599980 5.567887e-02 1.191469e-01 1 168087705 168089565 1861 - 0.702 0.364 -1.619
ENSG00000143147 E010 0.3686942 0.0311479130 8.114975e-01 8.803788e-01 1 168090446 168090563 118 - 0.147 0.101 -0.615
ENSG00000143147 E011 63.0495128 0.0095805405 3.287281e-02 7.755149e-02 1 168090564 168090668 105 - 1.718 1.813 0.322
ENSG00000143147 E012 186.1269507 0.0002726205 3.133991e-03 1.065857e-02 1 168096508 168097232 725 - 2.227 2.261 0.113
ENSG00000143147 E013 124.5635703 0.0002986573 2.589357e-07 2.427124e-06 1 168104477 168104894 418 - 1.992 2.117 0.420
ENSG00000143147 E014 0.5514428 0.0197476194 1.471528e-01 2.578160e-01 1 168104895 168104909 15 - 0.000 0.252 10.733
ENSG00000143147 E015 1.0685465 0.0260905969 1.224211e-01 2.234004e-01 1 168109842 168109962 121 - 0.479 0.183 -1.942
ENSG00000143147 E016 11.8165209 0.0015199346 1.753399e-01 2.951156e-01 1 168114456 168114549 94 - 1.028 1.125 0.351
ENSG00000143147 E017 0.6997360 0.0167080170 7.561898e-02 1.524961e-01 1 168118601 168118735 135 - 0.000 0.312 11.189
ENSG00000143147 E018 1.2449377 0.0142355609 4.735930e-01 6.125303e-01 1 168133876 168133921 46 - 0.257 0.365 0.706
ENSG00000143147 E019 5.4227320 0.0029852485 5.058351e-02 1.101925e-01 1 168134906 168135036 131 - 0.626 0.863 0.966
ENSG00000143147 E020 0.0000000       1 168135037 168135037 1 -      
ENSG00000143147 E021 7.3943604 0.0023052677 1.174153e-02 3.291743e-02 1 168136010 168136256 247 - 0.702 0.985 1.104
ENSG00000143147 E022 19.2487733 0.0090228158 3.579211e-01 5.023379e-01 1 168136257 168136738 482 - 1.254 1.295 0.146
ENSG00000143147 E023 16.3347982 0.0011451792 8.502904e-01 9.071371e-01 1 168136739 168136959 221 - 1.234 1.210 -0.082
ENSG00000143147 E024 4.2244688 0.0865324879 8.277280e-02 1.638958e-01 1 168137165 168137389 225 - 0.480 0.793 1.369
ENSG00000143147 E025 3.2259553 0.0147989929 1.902674e-02 4.939252e-02 1 168137390 168137667 278 - 0.344 0.716 1.795