ENSG00000143126

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000271332 ENSG00000143126 HEK293_OSMI2_2hA HEK293_TMG_2hB CELSR2 protein_coding protein_coding 8.225557 8.726333 6.546879 0.7311166 0.1381283 -0.4140186 0.2219632 0.0000000 0.8092913 0.0000000 0.468125859 6.3563046 0.03370417 0.00000000 0.1221667 0.12216667 1.640318e-01 3.073964e-05 FALSE TRUE
ENST00000489018 ENSG00000143126 HEK293_OSMI2_2hA HEK293_TMG_2hB CELSR2 protein_coding processed_transcript 8.225557 8.726333 6.546879 0.7311166 0.1381283 -0.4140186 0.4773903 0.6239613 0.3195303 0.1448363 0.007826588 -0.9439837 0.05617917 0.07093333 0.0488000 -0.02213333 5.296805e-01 3.073964e-05 FALSE TRUE
ENST00000498157 ENSG00000143126 HEK293_OSMI2_2hA HEK293_TMG_2hB CELSR2 protein_coding processed_transcript 8.225557 8.726333 6.546879 0.7311166 0.1381283 -0.4140186 1.3175940 2.0957092 0.7823222 0.2472194 0.068074983 -1.4101470 0.15372917 0.24850000 0.1193333 -0.12916667 7.402665e-02 3.073964e-05 TRUE FALSE
MSTRG.1744.2 ENSG00000143126 HEK293_OSMI2_2hA HEK293_TMG_2hB CELSR2 protein_coding   8.225557 8.726333 6.546879 0.7311166 0.1381283 -0.4140186 1.9771894 0.6996196 2.2758302 0.6996196 0.204277407 1.6876004 0.24942500 0.07703333 0.3489333 0.27190000 9.327217e-02 3.073964e-05 FALSE TRUE
MSTRG.1744.3 ENSG00000143126 HEK293_OSMI2_2hA HEK293_TMG_2hB CELSR2 protein_coding   8.225557 8.726333 6.546879 0.7311166 0.1381283 -0.4140186 1.3035410 1.3967530 1.1121350 0.4396288 0.420458262 -0.3261228 0.16683333 0.15776667 0.1705000 0.01273333 1.000000e+00 3.073964e-05 FALSE TRUE
MSTRG.1744.4 ENSG00000143126 HEK293_OSMI2_2hA HEK293_TMG_2hB CELSR2 protein_coding   8.225557 8.726333 6.546879 0.7311166 0.1381283 -0.4140186 2.8159866 3.9102896 0.9680124 0.4527201 0.222899352 -2.0030356 0.32563750 0.44580000 0.1467667 -0.29903333 3.073964e-05 3.073964e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000143126 E001 0.2987644 0.0290785164 1.364223e-01   1 109249539 109249575 37 + 0.240 0.000 -14.266
ENSG00000143126 E002 0.4439371 0.0215636789 4.967157e-02 1.085780e-01 1 109249576 109249603 28 + 0.324 0.000 -14.859
ENSG00000143126 E003 101.6381441 0.0203573757 4.285374e-07 3.841083e-06 1 109249604 109251126 1523 + 2.181 1.822 -1.203
ENSG00000143126 E004 26.1170946 0.0039424974 2.705281e-06 2.045692e-05 1 109251127 109251183 57 + 1.591 1.261 -1.142
ENSG00000143126 E005 76.1187848 0.0011366539 7.892203e-17 3.438717e-15 1 109251184 109251663 480 + 2.047 1.701 -1.166
ENSG00000143126 E006 244.7239729 0.0120884477 6.436107e-09 8.227403e-08 1 109251664 109253389 1726 + 2.531 2.240 -0.970
ENSG00000143126 E007 78.5825800 0.0023300964 3.883342e-04 1.729727e-03 1 109258432 109259079 648 + 1.968 1.819 -0.503
ENSG00000143126 E008 45.5628343 0.0004953856 2.043191e-05 1.264704e-04 1 109261042 109261264 223 + 1.771 1.560 -0.716
ENSG00000143126 E009 37.6472633 0.0005943059 1.194852e-05 7.798297e-05 1 109261513 109261628 116 + 1.703 1.464 -0.815
ENSG00000143126 E010 30.0790785 0.0056919059 6.876250e-04 2.854011e-03 1 109261808 109261896 89 + 1.604 1.370 -0.802
ENSG00000143126 E011 45.0879809 0.0148376086 1.137122e-01 2.109378e-01 1 109262287 109262444 158 + 1.713 1.606 -0.363
ENSG00000143126 E012 48.2659806 0.0109173004 1.440280e-01 2.535018e-01 1 109262806 109262969 164 + 1.731 1.642 -0.304
ENSG00000143126 E013 44.5472064 0.0005012520 4.840680e-02 1.063409e-01 1 109263142 109263267 126 + 1.700 1.605 -0.321
ENSG00000143126 E014 50.6292548 0.0091280724 2.814897e-01 4.213804e-01 1 109263611 109263777 167 + 1.734 1.675 -0.200
ENSG00000143126 E015 64.3823822 0.0006188721 6.771701e-01 7.819474e-01 1 109264078 109264365 288 + 1.805 1.796 -0.031
ENSG00000143126 E016 53.6485274 0.0004553323 5.052660e-01 6.410727e-01 1 109264454 109264628 175 + 1.693 1.736 0.143
ENSG00000143126 E017 52.8143512 0.0004829795 4.308282e-01 5.734417e-01 1 109264868 109265009 142 + 1.734 1.705 -0.099
ENSG00000143126 E018 40.3627496 0.0005420820 8.473580e-02 1.669815e-01 1 109265191 109265268 78 + 1.653 1.567 -0.293
ENSG00000143126 E019 37.7369540 0.0005712696 4.435281e-01 5.851083e-01 1 109265269 109265311 43 + 1.591 1.557 -0.119
ENSG00000143126 E020 63.1004561 0.0004949808 3.611775e-01 5.055599e-01 1 109265735 109265918 184 + 1.754 1.806 0.174
ENSG00000143126 E021 42.4795091 0.0128665036 3.352902e-01 4.790687e-01 1 109266105 109266206 102 + 1.558 1.653 0.326
ENSG00000143126 E022 1.3340015 0.0226195300 2.684568e-04 1.251281e-03 1 109266207 109266439 233 + 0.636 0.000 -16.445
ENSG00000143126 E023 45.0525204 0.0035303136 3.396558e-01 4.835848e-01 1 109267548 109267642 95 + 1.600 1.669 0.235
ENSG00000143126 E024 65.6677286 0.0038072740 7.871838e-01 8.636983e-01 1 109267851 109268060 210 + 1.787 1.815 0.097
ENSG00000143126 E025 60.2083034 0.0091058750 4.554904e-01 5.960125e-01 1 109268581 109268764 184 + 1.727 1.793 0.222
ENSG00000143126 E026 49.3469454 0.0015367233 2.282043e-01 3.602850e-01 1 109268880 109269008 129 + 1.638 1.713 0.253
ENSG00000143126 E027 64.8714076 0.0009989064 4.063797e-01 5.500319e-01 1 109269110 109269290 181 + 1.771 1.819 0.165
ENSG00000143126 E028 69.8557903 0.0036836680 4.222205e-01 5.653792e-01 1 109269424 109269591 168 + 1.848 1.821 -0.091
ENSG00000143126 E029 38.2460719 0.0011187102 3.202157e-01 4.633166e-01 1 109269694 109269726 33 + 1.534 1.603 0.233
ENSG00000143126 E030 58.0959551 0.0004302727 8.247034e-01 8.895638e-01 1 109269727 109269820 94 + 1.743 1.762 0.066
ENSG00000143126 E031 88.7667128 0.0003969916 1.551825e-01 2.686324e-01 1 109269933 109270133 201 + 1.963 1.918 -0.151
ENSG00000143126 E032 12.5735124 0.0013691325 1.133040e-02 3.195447e-02 1 109270134 109270425 292 + 1.237 1.008 -0.822
ENSG00000143126 E033 83.4558320 0.0003679973 7.113251e-01 8.083160e-01 1 109270426 109270600 175 + 1.911 1.906 -0.017
ENSG00000143126 E034 0.7394793 0.0156013683 9.632686e-02 1.848676e-01 1 109270601 109270823 223 + 0.394 0.109 -2.365
ENSG00000143126 E035 0.4439371 0.0215636789 4.967157e-02 1.085780e-01 1 109270824 109270926 103 + 0.324 0.000 -14.859
ENSG00000143126 E036 56.6446413 0.0004054363 3.635056e-01 5.079105e-01 1 109270927 109271039 113 + 1.709 1.762 0.179
ENSG00000143126 E037 41.8652985 0.0009916342 3.986924e-03 1.310598e-02 1 109271217 109271296 80 + 1.495 1.672 0.603
ENSG00000143126 E038 1.6607623 0.0083834729 2.929583e-01 4.339910e-01 1 109271297 109271385 89 + 0.507 0.332 -0.948
ENSG00000143126 E039 55.3305710 0.0006155678 1.452414e-04 7.265405e-04 1 109271386 109271512 127 + 1.595 1.798 0.686
ENSG00000143126 E040 2.4775714 0.0061386740 4.377524e-01 5.796451e-01 1 109271513 109271599 87 + 0.597 0.478 -0.556
ENSG00000143126 E041 67.7825619 0.0004004843 6.518300e-02 1.353389e-01 1 109271600 109271722 123 + 1.762 1.853 0.307
ENSG00000143126 E042 77.2755433 0.0004179065 3.664399e-01 5.107786e-01 1 109272278 109272405 128 + 1.850 1.896 0.157
ENSG00000143126 E043 1.2051864 0.0951753470 1.080566e-01 2.026530e-01 1 109272406 109272639 234 + 0.507 0.196 -1.952
ENSG00000143126 E044 64.0251097 0.0004057552 5.380423e-02 1.159171e-01 1 109272640 109272728 89 + 1.737 1.834 0.327
ENSG00000143126 E045 0.0000000       1 109272729 109272832 104 +      
ENSG00000143126 E046 98.8489836 0.0008429451 7.300785e-06 5.004022e-05 1 109272833 109273027 195 + 1.859 2.045 0.625
ENSG00000143126 E047 82.9202560 0.0022455950 9.483896e-06 6.338221e-05 1 109273166 109273336 171 + 1.762 1.979 0.730
ENSG00000143126 E048 2.2132623 0.0070048301 7.332255e-01 8.244739e-01 1 109273337 109273435 99 + 0.454 0.518 0.315
ENSG00000143126 E049 73.4067142 0.0004253814 4.921027e-11 9.155198e-10 1 109273436 109273670 235 + 1.638 1.946 1.040
ENSG00000143126 E050 30.7419850 0.0034543667 8.688391e-02 1.704064e-01 1 109273671 109274021 351 + 1.553 1.447 -0.363
ENSG00000143126 E051 31.3094929 0.0056636372 9.044976e-01 9.431763e-01 1 109274022 109274160 139 + 1.500 1.500 0.000
ENSG00000143126 E052 23.3419713 0.0296674913 3.339331e-01 4.776908e-01 1 109274161 109274163 3 + 1.306 1.414 0.376
ENSG00000143126 E053 479.8015035 0.0135423219 9.169269e-10 1.369081e-08 1 109274164 109275960 1797 + 2.435 2.775 1.131